Author: Leifu JiangPublisher: Leuven University Press
ISBN: 9789058675422
Category :
Languages : en
Pages : 128
Book Description
Role of Nitric Oxide Synthase in the Regulation of Pulmonary Vascular Tone
Author: Leifu JiangPublisher: Leuven University Press
ISBN: 9789058675422
Category :
Languages : en
Pages : 128
Book Description
Nitric Oxide in Pulmonary Processes
Author: Maria G. BelvisiPublisher: Springer
ISBN: 3034884745
Category : Medical
Languages : en
Pages : 250
Book Description
Nitric oxide is an endogenously produced gas with a wide range of biological effects and has been implicated in many physiological and pathophysiological processes. It is released by many cell types in various organs but is particularly important in the maintenance of normal lung function. Nitric oxide in exhaled breath has been identified as a marker for lung disease in some patients. Thus, it is appropriate to consider the lung separately for the role and functioning of nitric oxide. The authors identify key areas in the history, biochemistry, physiology, pathophysiology, immunology and clinical applications of nitric oxide in the lung. The contents of this book will be of particular importance to scientists and clinicians with an interest in lung disease. Moreover, the authors encompass state of the art opinions of and rational for the therapeutic potential of nitric oxide and its inhibitors.
Nitric Oxide and the Regulation of the Peripheral Circulation
Author: Philip J. KadowitzPublisher: Springer Science & Business Media
ISBN: 1461213266
Category : Medical
Languages : en
Pages : 384
Book Description
The Endothelium
Author: Michel FélétouPublisher: Morgan & Claypool Publishers
ISBN: 1615041230
Category : Science
Languages : en
Pages : 309
Book Description
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Role of Nitric Oxide and Prostacyclin in Modulating Pulmonary Vascular Tone
Author: Wisam ElbishtiThe Role of Endogenous Nitric Oxide in the Control of Pulmonary Vascular Tone
Author: Role of Nitric Oxide and Prostacyclin in Modulating Pulmonary Vascular Tone
Author: Wisam ElbishtiThe Physiological Role of Nitric Oxide in Regulating Vascular Tone
Author: Gordon Allan CohenRole of Neuronal Nitric Oxide Synthase in Human Vascular Tone and Systemic Haemodynamics in Vivo
Author: Husain ShabeehPublisher:
ISBN:
Category :
Languages : en
Pages : 454
Book Description
We found that intravenous SMTC increased systemic vascular resistance and blood pressure, whilst stroke volume, cardiac output and heart rate werereduced. Importantly, there was no effect on flow-mediated dilatation, an effect mediated by eNOS. These results suggest that nNOS has a major contribution to basal regulation of systemic vascular resistance in humans.
Pathophysiology and Clinical Applications of Nitric Oxide
Author: Gabor M. RubanyiPublisher: CRC Press
ISBN: 0203303725
Category : Science
Languages : en
Pages : 378
Book Description
Research on the key mediator nitric oxide has increased exponentially over the last ten years. It is now clear that, in addition to its role within the cardiovascular system, this mediator is also implicated in the normal physiological function and disease pathology of several organs and systems. A number of the fundamental research observations are now being developed into therapeutic principles and these are being pursued through clinical trials. This is the first work summarizing, in its two volumes, the quantum leap from basic science to clinical applications emerging from this decade of research.