Author: Wenise Wing-See WongPublisher:
ISBN:
Category :
Languages : en
Pages : 208
Book Description
Role of Actin Subdomain 1 Acidic Residues in Actomyosin and Regulation of Actomyosin Function
Author: Wenise Wing-See WongPublisher:
ISBN:
Category :
Languages : en
Pages : 208
Book Description
Molecular Interactions of Actin
Author: D.D. ThomasPublisher: Springer Science & Business Media
ISBN: 3540465588
Category : Science
Languages : en
Pages : 230
Book Description
Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion ("Molecular Interactions of Actin. Actin Structure and Actin-Binding Proteins") provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data. This book will appeal to research scientists seeking contemporary overviews of actin-myosin interaction and actin-based regulation. Contributors include senior scientists as well as the new breed of younger scientists.
Actin-Monomer-Binding Proteins
Author: Pekka LappalainenPublisher: Springer Science & Business Media
ISBN: 0387464077
Category : Science
Languages : en
Pages : 118
Book Description
This book provides a comprehensive view on actin monomer-binding proteins and the mechanisms by which they contribute to actin dynamics and various actin-dependent cellular processes. This new title contains chapters that describe the basic mechanisms of actin dynamics as well as the structural principles by which various actin-binding proteins interact with actin. The book is suitable further reading for students in advanced cell biology classes.
Functional Importance of Alpha-tropomyosin "off"-state Actin-binding Amino Acid Residues
Author: Rochelle Camellia DowdiePublisher:
ISBN:
Category :
Languages : en
Pages : 64
Book Description
ABSTRACT: Tropomyosin (TM) is a thin filament protein that is virtually expressed in all eukaryotic cells. It is an actin-adapted protein where in both muscle anD nonmuscle cells TM binds along F-actin and modulates actin filament dynamics and function. In the myocardium, TM is essential in regulating cardiac muscle performance and dynamics in association with other thin filament proteins. TM is a highly charged molecule, a key factor in its interaction with the myofilament proteins. In fact, its sequence is divided into 14 bands of predominantly negative charges that are subsequently divided into alternating [alpha]- and [beta]- bands. The seven [alpha]- bands are associated with the "off"-state binding of TM to actin and the seven [beta]- bands of TM are the "on"-state binding regions. While it has been suggested that the shifting of TM equilibrium between these states on actin plays a critcal role in actomyosin regualtion, the specific role of the predominant negative charges in the interacting zones have not been studied. We hypothesize that perturbation of the [alpha]- bands, by altering negatively charged residues in those regions will cause TM slipping at the "off"-state and lead to marked changes in cardiac muslce dynamics. To test this hypothesis we generated and characterized transgenic (TG) mouse lines overexpressing mutant [alpha]-TM bearing negative charged residue changes in the [alpha]-zones. We have successfully generated a transgenic DNA construct bearing the designed mutations in the [alpha]-zones of [alpha]-TM carboxyl region ([alpha]-TM-CTM). As a result we were able to generate and maintain stable transgenic mouse lines. Molecular analyses show the expression of the [alpha]-TM-CTM transgene at the mRNA and protein levels. Furthermore, we have generated a protein expression system that successfully yields the recombinant [alpha]-TM-CTM protein for future in vitro studies. Taken together, this work has generated and characterized a TG mouse model and expression system for structure-function studies of [alpha]-TM [alpha]-bands.
Dissertation Abstracts International
Author: Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 674
Book Description
Cytoskeleton
Author: Jose C. Jimenez-LopezPublisher: BoD – Books on Demand
ISBN: 9535131699
Category : Science
Languages : en
Pages : 344
Book Description
The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
The Regulation of Actomyosin by Tropomyosin and Troponin
Author: Jack Haim GersonCumulated Index Medicus
Author: Myosins
Author: Lynne M. ColuccioPublisher: Springer Science & Business Media
ISBN: 1402065191
Category : Science
Languages : en
Pages : 498
Book Description
This highly authoritative volume highlights the remarkable superfamily of molecular motors called myosins, which are involved in such diverse cellular functions as muscle contraction, intracellular transport, cell migration and cell division. In a timely compilation of chapters written by leading research groups that have made key discoveries in the field, the current understanding of the molecular mechanisms and biological functions of these intriguing proteins is explored.
Molecular Interactions of Actin
Author: C.G. dos RemediosPublisher: Springer Science & Business Media
ISBN: 354046560X
Category : Science
Languages : en
Pages : 272
Book Description
Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data. This book will appeal to research scientists seeking contemporary overviews of actin and its binding proteins. Contributors include senior scientists as well as the new breed of younger scientists.