Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays PDF Download

Author: OECD
Publisher: OECD Publishing
ISBN: 9264122818
Category :
Languages : en
Pages : 16

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Book Description
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...

Author: Bron Fane
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: National Research Council
Publisher: National Academies Press
ISBN: 9780309039796
Category : Social Science
Languages : en
Pages : 424

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Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.

Author: OECD
Publisher: OECD Publishing
ISBN: 9264243119
Category :
Languages : en
Pages : 15

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The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...

Author: Jerry J. Buccafusco
Publisher: CRC Press
ISBN: 1420041819
Category : Medical
Languages : en
Pages : 341

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Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309172829
Category : Science
Languages : en
Pages : 113

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US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

Author: Virginia E. Papaioannou
Publisher: CSHL Press
ISBN: 9780879696405
Category : Medical
Languages : en
Pages : 260

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Book Description
The generation of mutant mice raises many questions about the best means of phenotypic analysis, breeding, and maintenance. The answers are now available from two experts with a wealth of detailed knowledge never previously assembled in one volume. Informal and highly practical, this handbook provides step–by–step methods for troubleshooting experiments, from the basics of gene targeting through the analysis of postnatal effects.

Author: Minako Nagao
Publisher: John Wiley & Sons
ISBN:
Category : Medical
Languages : en
Pages : 398

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Current Toxicology Series Series Editors Diana Anderson Tno Bibra International Ltd, Surrey, UK Michael D Waters Consultant, Chapel Hill, NC, USA Timothy C Marrs Department of Health, London, UK Food Borne Carcinogens Heterocyclic Amines Edited by Minako Nagao, Tokyo University of Agriculture, Japan Takashi Sugimura, National Cancer Center, Japan Food Borne Carcinogens provides a comprehensive review of the genotoxic and carcinogenic activities of heterocyclic amines (HCAs) found in cooked foods. This unique and timely publication describes the latest research and offers an insight into new developments. Key topics covered include: * Combination effects of HCAs in carcinogenesis * Genetic alterations in animal tumours induced by HCAs * Adduct levels yielded in humans by ordinary exposure levels * Genetic polymorphisms in HCA metabolic enzymes and suspected individual differences in susceptibility to HCA carcinogenesis Written by world-renowned experts in the field, this book will be essential reading for toxicologists and cancer researchers working within industry, academia and government, particularly, food scientists, genetic toxicologists, biochemists, nutritionists and those investigating risk evaluation of HCA's and the regulation of environmental carcinogens. It will also be of interest to other scientists involved in the identification of naturally occurring antimutagens and anticarcinogens.

Author: OECD
Publisher: OECD Publishing
ISBN: 9264203907
Category :
Languages : en
Pages : 29

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Book Description
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of mutations induced by test chemicals.

Author: National Research Council
Publisher: National Academies Press
ISBN: 0309051266
Category : Science
Languages : en
Pages : 188

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Book Description
In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.