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Author: Tariq M. Rana Publisher: Academic Press ISBN: 9780123983169 Category : Medical Languages : en Pages : 0
Book Description
RNA research is interdisciplinary, using biochemical, molecular and cellular biology approaches to screen and identify RNAi in humans and animals. Current medical and disease models being researched include cancer, AIDS, regenerative medicine, and Hepatitis C, Alzheimers, Parkinson’s, and other neurological diseases. RNA Regulation in Human Development and Disease is the first summative publication to offer a review of the research, timely for the multi-disciplinary researchers and graduate students studying RNA. Using clear structure and different angles from which the subject is approached, this publication includes a broad range of topics on regulation and disease, as well as therapeutic development and current techniques are discussed. An aide in establishing collaborations between basic scientists and clinicians, RNA Regulation in Human Development and Disease is extremely valuable for researchers across the fundamental and biomedical sciences. The first single resource for RNA review for researchers across disciplines Assists in collaboration from basic scientists to clinicians by discussing therapeutic applications of RNA research Offers innovative tools, a collection of current techniques
Author: Tariq M. Rana Publisher: Academic Press ISBN: 9780123983169 Category : Medical Languages : en Pages : 0
Book Description
RNA research is interdisciplinary, using biochemical, molecular and cellular biology approaches to screen and identify RNAi in humans and animals. Current medical and disease models being researched include cancer, AIDS, regenerative medicine, and Hepatitis C, Alzheimers, Parkinson’s, and other neurological diseases. RNA Regulation in Human Development and Disease is the first summative publication to offer a review of the research, timely for the multi-disciplinary researchers and graduate students studying RNA. Using clear structure and different angles from which the subject is approached, this publication includes a broad range of topics on regulation and disease, as well as therapeutic development and current techniques are discussed. An aide in establishing collaborations between basic scientists and clinicians, RNA Regulation in Human Development and Disease is extremely valuable for researchers across the fundamental and biomedical sciences. The first single resource for RNA review for researchers across disciplines Assists in collaboration from basic scientists to clinicians by discussing therapeutic applications of RNA research Offers innovative tools, a collection of current techniques
Author: Publisher: Academic Press ISBN: 0128171944 Category : Medical Languages : en Pages : 444
Book Description
RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field
Author: Naoyuki Kataoka Publisher: Frontiers Media SA ISBN: 2889630978 Category : Languages : en Pages : 123
Book Description
This Research Topic addresses the human diseases caused by a malfunction of the RNA metabolism. We aim at strengthening the link between fundamental research and therapeutic applications. In eukaryotes, RNA is transcribed from genomic DNA. RNA molecules undergo multiple post-transcriptional processes such as splicing, editing, modification, translation, and degradation. A defect, mis-regulation, or malfunction of these processes often results in diseases in humans, referred to as 'RNA diseases'. There is an increasing number of studies focused on RNA diseases, which are aimed at uncovering the fundamental molecular mechanisms at play in order to develop therapeutic approaches.
Author: Tommaso Pizzorusso Publisher: Frontiers Media SA ISBN: 2889456579 Category : Neurosciences. Biological psychiatry. Neuropsychiatry Languages : en Pages : 346
Book Description
Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential.
Author: Chen Gao Publisher: ISBN: Category : Languages : en Pages : 210
Book Description
During cardiac development and pathological remodeling, there is a transcriptome maturation and remodeling event well established at transcription level. However, with high-throughput sequencing technology, we are able to obtain a more comprehensive understanding of the real transcriptome complexity at single base resolution. In order to understand the cardiac transcriptome complexity and dynamics during normal and disease conditions, we performed deep RNA- Sequencing on pressured overload induced mouse failing hearts and compared with sham operated control hearts. From this study, we have identified a significant number of genes undergo alternative splicing during heart disease. We have also provided evidence there is a large number of previously un-annotated novel splicing variants, lncRNA and novel transcript clusters, some of these could have potential impact on cardiac disease. From the sequencing analysis, we chose to carry out detailed characterization of a novel cardiac specific splicing variant in PKCalpha;. Both biochemistry and cell studies suggested this novel splicing variant has significant higher auto- phosphorylation level at baseline but has different activation profile responding to hypertrophic stimuli. This is potentially due to this novel PKCalpha; splicing variant has unique interacting partner and downstream target. We further demonstrated that, the alternative splicing of this novel PKCalpha; variant is, at least partially regulated by RBFox1. RNA splicing contributes significantly to total transcriptome complexity but its functional role and regulation in cardiac development and diseases remain poorly understood. Based on total transcriptome analysis, we identified a significant number of alternative RNA splicing events in mouse failing hearts that resembled the pattern in fetal hearts. A muscle specific isoform of an RNA splicing regulator RBFox1 (A2BP1) is induced during cardiac development. Inactivation of zRBFox1 gene in zebrafish led to lethal phenotype associated with impaired cardiac function. RBFox1 regulates alternative splicing of transcription factor MEF2s, producing splicing variants with distinct transcriptional activities and different impact on cardiac development. RBFox1 expression is diminished in mouse and human failing hearts. Restoring RBFox1 expression significantly attenuates hypertrophy and heart failure induced by pressure-overload in mice. Therefore, RBFox1-MEF2 represents a previously uncharacterized regulatory circuit in cardiac transcriptional network with important impact on both cardiac development and diseases.
Author: Tapas Kumar Kundu Publisher: Springer Science & Business Media ISBN: 9400745257 Category : Medical Languages : en Pages : 698
Book Description
Epigenetics fine-tunes the life processes dictated by DNA sequences, but also kick-starts pathophysiological processes including diabetes, AIDS and cancer. This volume tracks the latest research on epigenetics, including work on new-generation therapeutics.
Author: Gene W. Yeo Publisher: Springer ISBN: 9783319804842 Category : Medical Languages : en Pages : 326
Book Description
Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm.
Author: Eric H. Davidson Publisher: Elsevier ISBN: 0080455573 Category : Science Languages : en Pages : 303
Book Description
Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. The only book in the market that is solely devoted to the genomic regulatory code for animal development Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding Presents a comprehensive treatment of molecular control elements that determine the function of genes Provides a comparative treatment of development, based on principles rather than description of developmental processes Considers the evolutionary processes in terms of the structural properties of gene regulatory networks Includes 42 full-color descriptive figures and diagrams
Author: Suming Huang Publisher: Academic Press ISBN: 0128004711 Category : Science Languages : en Pages : 484
Book Description
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science
Author: Tariq M. Rana
Author: Tariq M. Rana
Author: 
Author: Maritza Jaramillo
Author: Naoyuki Kataoka
Author: Tommaso Pizzorusso
Author: Chen Gao
Author: Tapas Kumar Kundu
Author: Gene W. Yeo
Author: Eric H. Davidson
Author: Suming Huang