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Author: Esha Rami Publisher: Delve Publishing ISBN: 9781774695074 Category : Languages : en Pages : 0
Book Description
A huge number of messenger RNAs (mRNAs) and non-coding RNAs must be accurately expressed for cells to function normally. These RNAs take a role in transcription, RNA processing, and translation. An in-depth examination of RNA-mediated genome regulation at several levels has been provided in the book RNA-based Regulation in Human Health and Disease. Starting with the Introduction of RNA, RNA as a therapeutic target, a further section examines the various diseases and significant potential for RNA-based medicines and diagnostics in the future. The book helps researchers, students and clinicians across the world who will find this book very informative as well as practical.
Author: Esha Rami Publisher: Delve Publishing ISBN: 9781774695074 Category : Languages : en Pages : 0
Book Description
A huge number of messenger RNAs (mRNAs) and non-coding RNAs must be accurately expressed for cells to function normally. These RNAs take a role in transcription, RNA processing, and translation. An in-depth examination of RNA-mediated genome regulation at several levels has been provided in the book RNA-based Regulation in Human Health and Disease. Starting with the Introduction of RNA, RNA as a therapeutic target, a further section examines the various diseases and significant potential for RNA-based medicines and diagnostics in the future. The book helps researchers, students and clinicians across the world who will find this book very informative as well as practical.
Author: Robert B. Denman Publisher: ISBN: 9788130802213 Category : Carrier proteins Languages : en Pages : 214
Book Description
Introduction - The circle of life is a philosophical construct, for want of a better term that posits the interconnectedness of all living things. In the movie The Lion King which brought the term to the consciousness of the Western mind, Mufasa tries to explain the concept to his heir-apparent, Simba, by saying, we eat the antelope, but when we die, we become the grass that they eat . While the circle of life has an uncanny resonance with something deep within, especially for children, being Disney marketing magic it is never spelled out what actually connects us. I would submit to you that what this book demonstrates is that RNA binding proteins (RBPs) are some of the stuff connecting the circle of life. They are ageless, they are ubiquitous, and they are diverse. Found in all kingdoms, phyla and subphyla they impinge on all aspects of cellular metabolism from the transcription and splicing of messenger RNAs, to the formation of ribosomal RNA (see Aveilla et al. Chapter 11), from the translation of messenger RNAs (see Zhong et al. Chapter 1), to the timing of their translation and their degradation (see Pelletier et al. Chapter 2 and Vessey et al. Chapter 5). They are chaperones and repressors. More broadly they are regulators, which are in turn are regulated by a host of post-translational modifications (see Gopal et al. Chapter 3 and Kobarg Chapter 4). They play important roles in the differentiation of the nervous system (see Kawahara et al. Chapter 6), in muscle development (see Denman Chapter 7) and in germ line development (see Vessey et al. Chapter 5). Correspondingly, as befits a central role in metabolism, their loss or mutation can have profound organismal affects, from outright lethality to cancer (see Noubissi et al. Chapter 8), muscular disorders (see Meola et al. Chapter 9), eye disorders (see Schreuder et al. Chapter 10), bone marrow failure (see Aveilla et al. Chapter 11) epilepsy and mental retardation (Zhong et al. Chapter 1). Quite simply, they are RNA binding proteins . I would therefore invite the interested reader on an abbreviated tour of the circle of life that is contained in this slender tome. Of course, the very enterprise of making a book places constraints on what is included and what is not. As there are currently more than 30,000 papers on PubMed dealing with RNA binding proteins it is probable that many a would-be-reader will not find his or her favorite RBP reviewed here. Nevertheless, I would commend this book as a representative sampling of those articles, and therefore a worthwhile read for several reasons. First, the modular architecture of RBPs produces diversity via the mixing of a limited set of RNA binding motifs. Doubtless, one of the motifs the would-be reader is familiar with is discussed in these pages. Therefore, this book would offer a unique view of this motif operating in a different context. Second, the most common problem attended to within the field of RNA binding proteins is, What RNAs bind to a particular RBP and how do we know they are bona fide? By reading this book you will see how others have dealt with, or are dealing with this problem providing you the reader with the insight needed to attack this problem on another front. Finally, the dynamism of RBP-RNA interactions, coupled with their propensity to form larger aggregates make it likely that the RBP most familiar to a would-be reader associates with one or more of the RBPs reviewed here. If so, I would say, in order to know thyself, know thy neighbor . It is after all the circle of life.
Author: National Academies of Sciences, Engineering, and Medicine Publisher: National Academies Press ISBN: 0309465184 Category : Technology & Engineering Languages : en Pages : 189
Book Description
Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.
Author: Philippa C. Matthews Publisher: Oxford University Press ISBN: 0191057673 Category : Medical Languages : en Pages : 224
Book Description
The Tropical Medicine Notebook is a new concept in providing a concise overview of the key topics in tropical medicine, using short notes, diagrams, maps, and tables to present the material in an accessible, engaging, memorable, and interesting way. The format is generally a page per topic, with division of each page into subsections by boxes to make it easy to find the relevant information. Cross-referencing is provided to allow quick linking between relevant sections of the book. Providing the key information in bite-size chunks, the Tropical Medicine Notebook is a useful companion to more comprehensive texts. Divided into eight sections; the first five cover infections caused by bacteria, viruses, fungi, protozoa and helminths, followed by a further three which present the topics of vector biology, disease syndromes and envenomation. Where relevant, the section is prefaced by a classification system to provide a logical overview, helping with assimilation of information and highlighting important relationships between organisms. It is an ideal learning and revision guide for students or trainees in infection, microbiology, and tropical medicine, as well as being a useful reference resource for healthcare and laboratory staff across the wide range of disciplines to which infection may present.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 0309314003 Category : Medical Languages : en Pages : 310
Book Description
In the past half century, deadly disease outbreaks caused by novel viruses of animal origin - Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency virus), several influenza subtypes, and the SARS (sudden acute respiratory syndrome) and MERS (Middle East respiratory syndrome) coronaviruses - have underscored the urgency of understanding factors influencing viral disease emergence and spread. Emerging Viral Diseases is the summary of a public workshop hosted in March 2014 to examine factors driving the appearance, establishment, and spread of emerging, re-emerging and novel viral diseases; the global health and economic impacts of recently emerging and novel viral diseases in humans; and the scientific and policy approaches to improving domestic and international capacity to detect and respond to global outbreaks of infectious disease. This report is a record of the presentations and discussion of the event.
Author: Bryan Cullen Publisher: Oxford University Press ISBN: 9780199633821 Category : Gene Expression Regulation. Languages : en Pages : 220
Book Description
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author: Volker Thiel Publisher: ISBN: 9781912530359 Category : Science Languages : en Pages : 0
Book Description
Paperback. ISBN 978-1-912530-35-9. In this timely book, internationally renowned experts review literally every aspect of cutting edge coronavirus research providing the first coherent picture of the molecular and cellular biology since the outbreak of SARS in 2003. Essential reading for all coronavirologists as well as scientists working on other viruses of the respiratory and/or gastrointestinal tract.
Author: Ellen G. Strauss Publisher: Elsevier ISBN: 0080553168 Category : Medical Languages : en Pages : 476
Book Description
Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text
Author: Rita Sattler Publisher: Springer ISBN: 331989689X Category : Medical Languages : en Pages : 310
Book Description
It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--‐directional transcription and production of repeat associated non--‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Author: Esha Rami
Author: Esha Rami
Author: Emanuele Buratti
Author: Robert B. Denman
Author: National Academies of Sciences, Engineering, and Medicine
Author: Philippa C. Matthews
Author: Institute of Medicine
Author: Bryan Cullen
Author: Volker Thiel
Author: Ellen G. Strauss
Author: Rita Sattler