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Author: Xiuwen Duan Publisher: ISBN: Category : Languages : en Pages :
Book Description
Empirical Bayes methods have been around for a long time and have a wide range of applications. These methods provide a way in which historical data can be aggregated to provide estimates of the posterior mean. This thesis revisits some of the empirical Bayesian methods and develops new applications. We first look at a linear empirical Bayes estimator and apply it on ranking and symbolic data. Next, we consider Tweedie's formula and show how it can be applied to analyze a microarray dataset. The application of the formula is simplified with the Pearson system of distributions. Saddlepoint approximations enable us to generalize several results in this direction. The results show that the proposed methods perform well in applications to real data sets.
Author: Xiuwen Duan Publisher: ISBN: Category : Languages : en Pages :
Book Description
Empirical Bayes methods have been around for a long time and have a wide range of applications. These methods provide a way in which historical data can be aggregated to provide estimates of the posterior mean. This thesis revisits some of the empirical Bayesian methods and develops new applications. We first look at a linear empirical Bayes estimator and apply it on ranking and symbolic data. Next, we consider Tweedie's formula and show how it can be applied to analyze a microarray dataset. The application of the formula is simplified with the Pearson system of distributions. Saddlepoint approximations enable us to generalize several results in this direction. The results show that the proposed methods perform well in applications to real data sets.
Author: J.S. Maritz Publisher: CRC Press ISBN: 1351080113 Category : Mathematics Languages : en Pages : 296
Book Description
The second edition of Empirical Bayes Methods details are provided of the derivation and the performance of empirical Bayes rules for a variety of special models. Attention is given to the problem of assessing the goodness of an empirical Bayes estimator for a given set of prior data. A chapter is devoted to a discussion of alternatives to the empirical Bayes approach and there is also a chapter giving details of several actual applications of empirical Bayes method.
Author: Bradley Efron Publisher: Cambridge University Press ISBN: 1139492136 Category : Mathematics Languages : en Pages :
Book Description
We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.
Author: Bradley P. Carlin Publisher: CRC Press ISBN: 9781584886983 Category : Mathematics Languages : en Pages : 552
Book Description
Broadening its scope to nonstatisticians, Bayesian Methods for Data Analysis, Third Edition provides an accessible introduction to the foundations and applications of Bayesian analysis. Along with a complete reorganization of the material, this edition concentrates more on hierarchical Bayesian modeling as implemented via Markov chain Monte Carlo (MCMC) methods and related data analytic techniques. New to the Third Edition New data examples, corresponding R and WinBUGS code, and homework problems Explicit descriptions and illustrations of hierarchical modeling—now commonplace in Bayesian data analysis A new chapter on Bayesian design that emphasizes Bayesian clinical trials A completely revised and expanded section on ranking and histogram estimation A new case study on infectious disease modeling and the 1918 flu epidemic A solutions manual for qualifying instructors that contains solutions, computer code, and associated output for every homework problem—available both electronically and in print Ideal for Anyone Performing Statistical Analyses Focusing on applications from biostatistics, epidemiology, and medicine, this text builds on the popularity of its predecessors by making it suitable for even more practitioners and students.
Author: Bradley P. Carlin Publisher: Chapman and Hall/CRC ISBN: 9781584881704 Category : Mathematics Languages : en Pages : 440
Book Description
In recent years, Bayes and empirical Bayes (EB) methods have continued to increase in popularity and impact. Building on the first edition of their popular text, Carlin and Louis introduce these methods, demonstrate their usefulness in challenging applied settings, and show how they can be implemented using modern Markov chain Monte Carlo (MCMC) methods. Their presentation is accessible to those new to Bayes and empirical Bayes methods, while providing in-depth coverage valuable to seasoned practitioners. With its broad appeal as a text for those in biomedical science, education, social science, agriculture, and engineering, this second edition offers a relatively gentle and comprehensive introduction for students and practitioners already familiar with more traditional frequentist statistical methods. Focusing on practical tools for data analysis, the book shows how properly structured Bayes and EB procedures typically have good frequentist and Bayesian performance, both in theory and in practice.
Author: Richard McElreath Publisher: CRC Press ISBN: 1315362619 Category : Mathematics Languages : en Pages : 488
Book Description
Statistical Rethinking: A Bayesian Course with Examples in R and Stan builds readers’ knowledge of and confidence in statistical modeling. Reflecting the need for even minor programming in today’s model-based statistics, the book pushes readers to perform step-by-step calculations that are usually automated. This unique computational approach ensures that readers understand enough of the details to make reasonable choices and interpretations in their own modeling work. The text presents generalized linear multilevel models from a Bayesian perspective, relying on a simple logical interpretation of Bayesian probability and maximum entropy. It covers from the basics of regression to multilevel models. The author also discusses measurement error, missing data, and Gaussian process models for spatial and network autocorrelation. By using complete R code examples throughout, this book provides a practical foundation for performing statistical inference. Designed for both PhD students and seasoned professionals in the natural and social sciences, it prepares them for more advanced or specialized statistical modeling. Web Resource The book is accompanied by an R package (rethinking) that is available on the author’s website and GitHub. The two core functions (map and map2stan) of this package allow a variety of statistical models to be constructed from standard model formulas.
Author: Nikolaos Ignatiadis Publisher: ISBN: Category : Languages : en Pages :
Book Description
In an empirical Bayes analysis, we use data from repeated sampling to imitate inferences made by an oracle Bayesian with extensive knowledge of the data-generating distribution. Existing results provide a comprehensive characterization of when and why empirical Bayes point estimates accurately recover oracle Bayes behavior--in particular when the likelihood of the individual statistical problems is known and all problems are relevant to each other. In this thesis, we build upon advances in the theory of nonparametric statistics, machine learning, and computation to make three-fold contributions to the empirical Bayes literature: 1) We develop flexible and practical confidence intervals that provide asymptotic frequentist coverage of empirical Bayes estimands, such as the posterior mean or the local false sign rate. The coverage statements hold even when the estimands are only partially identified or when empirical Bayes point estimates converge very slowly. 2) We show that it is possible to achieve near-Bayes optimal mean squared error for the estimation of n effect sizes in the setting where both the prior and the per-problem likelihood are unknown. The requirement of our method is that we have access to replicated data, that is, each effect size of interest is estimated from K> 1 noisy observations. 3) We tackle the issue of relevance in empirical Bayes estimation of effect sizes. We propose a method that shrinks toward a per-problem location determined by a machine learning model prediction of the effect given side-information. We establish an extension to the classic result of James-Stein, whereby our proposed estimator dominates the sample mean for each problem under quadratic risk; even if the side-information contains no information about the true effects, or the machine learning model is arbitrarily miscalibrated. Taken together, these results broaden the applicability of empirical Bayes methods in areas such as genomics, and large scale experimentation, and demonstrate that it is fruitful to revisit traditional ideas in the empirical Bayes literature through a modern lens. The above results largely draw upon the following papers: Ignatiadis and Wager (2019, 2022) and Ignatiadis, Saha, Sun, and Muralidharan (2021).
Author: Xiuwen Duan
Author: Xiuwen Duan
Author: J.S. Maritz
Author: J. S. Maritz
Author: Bradley Efron
Author: Bradley P. Carlin
Author: Bradley P. Carlin
Author: Bradley P. Carlin
Author: Richard McElreath
Author: Hubert Kostal
Author: Nikolaos Ignatiadis