Author: Ashok K Singh
Publisher:
ISBN:
Category : Electronic books
Languages : en
Pages : 0

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Book Description
Target recognition is important for the identification of drugs with a high target specificity and/or for the development of existing drugs that could be replicated for the treatment of SARS-CoV-2 infections. Since SARS-CoV-2 is a pathogen recently discovered, no specific medicines have been identified or are available at present. The scientific community had proposed list of current drugs with therapeutic potential for COVID-19 on the basis of genomic sequence information coupled with protein structure modeling, posing an effective and productive therapeutic approach for repurposing existing drugs. The possible therapeutics for the treatment of COVID-19 involves a wide range of alternatives, encompassing nucleic acid-based treatments directed at the expression of genes of viruses, cytokine therapy, genetic engineered and vectored antibodies, and different formulations of vaccines. The future prospective in the treatment approaches the exploration of antiviral therapy, such as screening of prevailing molecules or libraries, testing of existing broad-spectrum antiviral medications, modern drug discovery focused on genomic knowledge and biochemical properties of various coronaviruses to create new targeted drugs.

Author: Megha Agrawal
Publisher: BoD – Books on Demand
ISBN: 183968626X
Category : Medical
Languages : en
Pages : 646

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Book Description
This book provides an inclusive and comprehensive discussion of the transmission, science, biology, genome sequencing, diagnostics, and therapeutics of COVID-19. It also discusses public and government health measures and the roles of media as well as the impact of society on the ongoing efforts to combat the global pandemic. It addresses almost every topic that has been studied so far in the research on SARS-CoV-2 to gain insights into the fundamentals of the disease and mitigation strategies. This volume is a useful resource for virologists, epidemiologists, biologists, medical professionals, public health and government professionals, and all global citizens who have endured and battled against the pandemic.

Author: Debmalya Barh
Publisher: Elsevier
ISBN: 0323917941
Category : Business & Economics
Languages : en
Pages : 462

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Book Description
Omics Approaches and Technologies in COVID-19 discusses current and in development technologies used to fight the SARS-CoV-2 pandemic. Based on the research developed since the virus' outbreak, experts from around the world present perspectives on how recent technologies can help diagnose, treat and control. The book discusses topics such as genomics, meta-genomics, nutrigenomics, transcriptomics, proteomics, metabolomics, epigenomics, multi-omics and pan-genomics approaches, CRISPR, host-pathogen interactions, systems biology, artificial intelligence and machine learning applied to COVID-19, bioinformatics, mathematical modeling, and big data. In addition, it presents smart technologies to control SARS-CoV-2 transmission and technologies for the prediction of patients' health conditions and treatment outcomes. This is a valuable resource for graduate students, researchers and members of the biomedical field who are interested in learning more about novel approaches and technologies used to tackle the COVID-19 pandemic. Presents an overview of various omics-based strategies used in identifying the origin of SARS-CoV-2 Discusses omics approaches used in developing novel rapid diagnostics for COVID-19 Brings information on how omics technologies have minimized the time taken to develop potential drugs and vaccines Explains how applications of digital and smart technologies can be used to control the pandemic

Author: Shailendra K. Saxena
Publisher:
ISBN: 9789811548154
Category : Coronavirus infections
Languages : en
Pages :

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Book Description
This book provides a comprehensive overview of recent novel coronavirus (SARS-CoV-2) infection, their biology and associated challenges for their treatment and prevention of novel Coronavirus Disease 2019 (COVID-19). Discussing various aspects of COVID-19 infection, including global epidemiology, genome organization, immunopathogenesis, transmission cycle, diagnosis, treatment, prevention, and control strategies, it highlights host-pathogen interactions, host immune response, and pathogen immune invasion strategies toward developing an immune intervention or preventive vaccine for COVID-19. An understanding of the topics covered in the book is imperative in the context of designing strategies to protect the human race from further losses and harm due to SARS-CoV-2 infection causing COVID-19.

Author: Sepp Hochreiter
Publisher: Springer
ISBN: 354071233X
Category : Science
Languages : en
Pages : 497

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Book Description
This book constitutes the refereed proceedings of the First International Bioinformatics Research and Development Conference, BIRD 2007, held in Berlin, Germany in March 2007. The 36 revised full papers are organized in topical sections on microarray and systems biology and networks, medical, SNPs, genomics, systems biology, sequence analysis and coding, proteomics and structure, databases, Web and text analysis.

Author: Manja Marz
Publisher: MDPI
ISBN: 3039218824
Category : Science
Languages : en
Pages : 330

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Book Description
Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.

Author: Farid A. Badria
Publisher: BoD – Books on Demand
ISBN: 1839685204
Category : Medical
Languages : en
Pages : 236

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Book Description
Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Author: Joseph Loscalzo
Publisher: Harvard University Press
ISBN: 0674436539
Category : Medical
Languages : en
Pages : 449

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Book Description
Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.

Author: Daniele Focosi
Publisher: Springer Nature
ISBN: 3030873242
Category : Medical
Languages : en
Pages : 140

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Book Description
This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

Author: Shao Li
Publisher: Springer Nature
ISBN: 9811607532
Category : Medical
Languages : en
Pages : 480

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Book Description
This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.