Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals

Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals PDF Author: Canada. Health Canada
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

Book Description
Summarizes proceedings and discussions, and includes contributed papers, from a workshop held to investigate the feasibility of a study of the chronic neurotoxicity of aluminium administered in drinking water of animals. Such a study could be used to establish a health-based guideline for human exposure to aluminium in drinking water. The papers addressed the following issues: problems involved in the assessment of the human health effects of aluminium in drinking water; the importance of aluminium speciation and substances that affect speciation; the appropriateness of an animal study in human risk assessment; the best animal model and the appropriate end-points to be measured; aluminium absorption, accumulation site and pathway, and effects of age on accumulation of aluminium in animals; and methods for avoiding contamination from aluminium during an animal study.

Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals

Report of the Workshop on the Feasibility of a Chronic Neurotoxicity Study of Aluminum Administered in the Drinking Water of Animals PDF Author: Canada. Health Canada
Publisher:
ISBN:
Category :
Languages : en
Pages : 63

Book Description


Arsenic in Drinking Water

Arsenic in Drinking Water PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 0309076293
Category : Nature
Languages : en
Pages : 242

Book Description
Having safe drinking water is important to all Americans. The Environmental Protection Agency's decision in the summer of 2001 to delay implementing a new, more stringent standard for the maximum allowable level for arsenic in drinking water generated a great deal of criticism and controversy. Ultimately at issue were newer data on arsenic beyond those that had been examined in a 1999 National Research Council report. EPA asked the National Research Council for an evaluation of the new data available. The committee's analyses and conclusions are presented in Arsenic in Drinking Water: 2001 Update. New epidemiological studies are critically evaluated, as are new experimental data that provide information on how and at what level arsenic in drinking water can lead to cancer. The report's findings are consistent with those of the 1999 report that found high risks of cancer at the previous federal standard of 50 parts per billion. In fact, the new report concludes that men and women who consume water containing 3 parts per billion of arsenic daily have about a 1 in 1,000 increased risk of developing bladder or lung cancer during their lifetime.

Neurotoxicity of Aluminum

Neurotoxicity of Aluminum PDF Author: Qiao Niu
Publisher: Springer
ISBN: 9811313709
Category : Medical
Languages : en
Pages : 191

Book Description
This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity.

The Ethics of Research Involving Animals

The Ethics of Research Involving Animals PDF Author:
Publisher:
ISBN: 9781904384106
Category : Animal experimentation
Languages : en
Pages : 335

Book Description
A report of the Nuffield Council on Bioethics working party investigating the ethical issues of research involving animals.

Guidelines for Canadian Drinking Water Quality

Guidelines for Canadian Drinking Water Quality PDF Author:
Publisher:
ISBN: 9780660460239
Category : Drinking water
Languages : en
Pages : 0

Book Description
"Malathion is a registered insecticide and acaricide used on a wide variety of sites including agricultural and non-agricultural sites. In 2018 (the most recent year for which data are available), over 25 000 kg of malathion was sold in Canada. Malathion may be released into surface water or soil as runoff from the application site. Malathion is not usually found in drinking water sources in Canada. Low levels of malathion have been found in several Canadian provinces. The maximum reported concentrations are well below the MAC. Malathion is rarely detected in foods"--Executive summary.

Fluoride in Drinking Water

Fluoride in Drinking Water PDF Author: National Research Council
Publisher: National Academies Press
ISBN: 030910128X
Category : Nature
Languages : en
Pages : 531

Book Description
Most people associate fluoride with the practice of intentionally adding fluoride to public drinking water supplies for the prevention of tooth decay. However, fluoride can also enter public water systems from natural sources, including runoff from the weathering of fluoride-containing rocks and soils and leaching from soil into groundwater. Fluoride pollution from various industrial emissions can also contaminate water supplies. In a few areas of the United States fluoride concentrations in water are much higher than normal, mostly from natural sources. Fluoride is one of the drinking water contaminants regulated by the U.S. Environmental Protection Agency (EPA) because it can occur at these toxic levels. In 1986, the EPA established a maximum allowable concentration for fluoride in drinking water of 4 milligrams per liter, a guideline designed to prevent the public from being exposed to harmful levels of fluoride. Fluoride in Drinking Water reviews research on various health effects from exposure to fluoride, including studies conducted in the last 10 years.

Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories

Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories PDF Author: United States. Environmental Protection Agency. Office of Science and Technology
Publisher:
ISBN:
Category : Fish as food
Languages : en
Pages : 400

Book Description


Life Cycle Assessment (LCA)

Life Cycle Assessment (LCA) PDF Author: Allan Astrup Jensen
Publisher:
ISBN:
Category : Business & Economics
Languages : en
Pages : 132

Book Description
Life Cycle Assessment

Toxicological Profile for 2,4,6-trinitrotoluene

Toxicological Profile for 2,4,6-trinitrotoluene PDF Author:
Publisher:
ISBN:
Category : 2,4,6-trinitrotoluene
Languages : en
Pages : 212

Book Description