Rehabilitation of Cognitive Dysfunction in Survivors of Breast Cancer PDF Download
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Author: Katherine R.P. George Publisher: ISBN: Category : Languages : en Pages :
Book Description
Purpose: Cancer-related cognitive impairment (CRCI) has been associated with fatigue, emotional distress, reduced quality of life, and caregiver strain. A potential treatment option for those with CRCI is cognitive rehabilitation, a behavioural approach to improve cognitive skills and quality of life. There have been some studies that involve caregivers in aspects of rehabilitation. There are no studies in the literature however, that include direct retraining of survivors on lost functions and concurrent participation by their caregivers across all sessions. To fill this gap, a comprehensive 10-week cognitive rehabilitation program (CRP) was created, with aims to generalize improvement to everyday life in survivors of breast cancer. Methods: A manualized CRP was developed and piloted with breast cancer survivors (BCSs) and their training partners. The program focused on psychoeducation and direct training on communication strategies, breathing/relaxation techniques, simple and complex attention, and higher-order thinking. Outcome measures included feasibility (retention and attendance rates), acceptability (homework compliance, session and program satisfaction), and measures of cognitive functioning and quality of life. BCSs and their individual partner underwent assessments at baseline, immediately after completing the program, and approximately 10 weeks later in order to investigate maintenance effects. Results: Six BCSs (ages 44-59; ≥1 year post-chemotherapy) and their training partners enrolled and completed this study with a (100% retention rate). Rates of attendance were high for both BCSs and their training partners (94% and 92.5% respectively) with all participants indicating high levels of satisfaction with the iv program. Repeated measures analyses of variance (ANOVAs) did not reveal a significant main effect for time on measures of sustained attention, processing speed, executive function, fluency (semantic and phonemic), verbal and visuospatial learning, recall and recognition. Repeated measures ANOVA revealed a significant main effect for time on measures of attentional capacity, focused attention, motor dexterity with the non-dominant hand, confrontation naming, and overall quality of life. Additionally, analyses using adjusted reliable change indices (RCI) were conducted on individual cases. RCIs yielded no change on most measures across time.
Author: Katherine R.P. George Publisher: ISBN: Category : Languages : en Pages :
Book Description
Purpose: Cancer-related cognitive impairment (CRCI) has been associated with fatigue, emotional distress, reduced quality of life, and caregiver strain. A potential treatment option for those with CRCI is cognitive rehabilitation, a behavioural approach to improve cognitive skills and quality of life. There have been some studies that involve caregivers in aspects of rehabilitation. There are no studies in the literature however, that include direct retraining of survivors on lost functions and concurrent participation by their caregivers across all sessions. To fill this gap, a comprehensive 10-week cognitive rehabilitation program (CRP) was created, with aims to generalize improvement to everyday life in survivors of breast cancer. Methods: A manualized CRP was developed and piloted with breast cancer survivors (BCSs) and their training partners. The program focused on psychoeducation and direct training on communication strategies, breathing/relaxation techniques, simple and complex attention, and higher-order thinking. Outcome measures included feasibility (retention and attendance rates), acceptability (homework compliance, session and program satisfaction), and measures of cognitive functioning and quality of life. BCSs and their individual partner underwent assessments at baseline, immediately after completing the program, and approximately 10 weeks later in order to investigate maintenance effects. Results: Six BCSs (ages 44-59; ≥1 year post-chemotherapy) and their training partners enrolled and completed this study with a (100% retention rate). Rates of attendance were high for both BCSs and their training partners (94% and 92.5% respectively) with all participants indicating high levels of satisfaction with the iv program. Repeated measures analyses of variance (ANOVAs) did not reveal a significant main effect for time on measures of sustained attention, processing speed, executive function, fluency (semantic and phonemic), verbal and visuospatial learning, recall and recognition. Repeated measures ANOVA revealed a significant main effect for time on measures of attentional capacity, focused attention, motor dexterity with the non-dominant hand, confrontation naming, and overall quality of life. Additionally, analyses using adjusted reliable change indices (RCI) were conducted on individual cases. RCIs yielded no change on most measures across time.
Author: Christina A. Meyers Publisher: Cambridge University Press ISBN: 9781107411814 Category : Medical Languages : en Pages : 0
Book Description
This book is a unique resource on the influence cancer and cancer treatments have on cognition. The majority of cancer patients on active treatment experience cognitive impairments often referred to as 'chemobrain' or 'chemofog'. In addition, patients with primary or metastatic tumors of the brain often experience direct neurologic symptoms. This book helps health care professionals working with cancer patients who experience cognitive changes and provides practical information to help improve care by reviewing and describing brain-behavior relationships; research-based evidence on cognitive changes that occur with various cancers and cancer treatments; assessment techniques, including neurocognitive assessment and neuroimaging techniques; and intervention strategies for affected patients. In short, it will explain how to identify, assess and treat these conditions.
Author: Adele Deborah Lenae Crouch Publisher: ISBN: Category : Languages : en Pages : 234
Book Description
Up to 75% of the more than 3.5 million breast cancer survivors (BCS) living in the United States report cognitive dysfunction. However, little is known about cognitive dysfunction among older BCS, who may be at greater risk. Therefore, the purpose of this dissertation was to characterize cognitive dysfunction in older BCS. Specific aims included: (1) synthesize the literature regarding cognitive dysfunction in older BCS; and (2) examine the relationships between a) objective cognitive function (immediate memory, delayed memory, attention, executive function-working memory, verbal fluency) and subjective cognitive function (attention); b) demographic factors, medical factors, treatment factors, and cancer-related symptoms (depressive symptoms, anxiety, fatigue, sleep disturbance) and cognitive function; and c) comorbidity and cognitive function and physical functioning, and quality of life (QoL) in older BCS. In an integrative review, to address aim 1, 12 studies were identified. Up to 41% of older BCS showed objective cognitive dysfunction on neuropsychological assessment, up to 64% reported subjective cognitive dysfunction concerns pre-treatment, and 50% incurred cognitive decline from pre- to post-treatment. Cognitive dysfunction was associated with older age, multiple comorbidities, chemotherapy, sleep disturbance, neuropsychological symptom cluster, frailty, and poorer QoL. To address aim 2, data were leveraged from a large, nationwide, QoL in younger versus older BCS study (PI: Champion), which included 335 older BCS who were e"0 years of age, had breast cancer (stage I-IIIa), received chemotherapy, and were 3-8 years post-diagnosis without recurrence. Findings included up to 19% of older BCS had mild-moderate objective cognitive dysfunction on at least one neuropsychological assessment, with 26% reporting poor-moderate subjective attention function. BCS, who were older, had less education and more depressive symptoms had greater cognitive dysfunction. Objective attention and executive function-working memory significantly and positively correlated with subjective attention. In turn, subjective cognitive dysfunction and increased number of comorbidities were related to poorer physical functioning. Subjective cognitive dysfunction was also related to poorer QoL. The findings from this study highlights the prevalence and complexity of cognitive dysfunction in older BCS. Further research is needed to better understand the intersection of aging, cancer, comorbidities and cognitive dysfunction and the negative implications in older BCS
Author: Robert Ferguson Publisher: Oxford University Press ISBN: 0197521592 Category : Medical Languages : en Pages : 176
Book Description
Cancer-related cognitive impairment (CRCI) may affect nearly half of all cancer survivors and can persist for years after completing cancer treatment. Memory and Attention Adaptation Training (MAAT) is a cognitive-behavioral therapy offering evidence-based, nonpharmacological treatment of this common survivorship condition. Organized into a session-by-session Clinician Manual and related Survivor Workbook, MAAT is conducted in eight treatment visits and has been demonstrated effective when delivered through telehealth technology, so survivors can readily fit MAAT into their busy lives. The MAAT Clinician Manual provides a clearly written summary of the scientific literature on CRCI and detailed guidance for each visit, including an agenda outline, in-depth discussion, and accompanying fidelity checklist in the appendix. Designed to be used in conjunction with the Survivor Workbook, the Clinician Manual also includes the full text of the workbook in a separate appendix, giving clinicians convenient one-volume access to the complete material.
Author: Adele Crouch Publisher: ISBN: Category : Languages : en Pages :
Book Description
Background/Framework: For millions of cancer survivors, cognitive dysfunction is a prevalent, severe, and persistent problem that is associated with poorer quality of life. Unfortunately, the scientific basis for managing these cognitive changes in cancer survivors is extremely limited. Available evidence from pilot studies, including work by our own group, suggests that computerized cognitive training, which is based on the principles of neuroplasticity (ability of brain neurons to re-organize and form new neural networks), may be a viable treatment option. However, previous trials have been limited by their designs (failure to have attention control comparison), delivery (failure to offer in the home) and lack of inclusion of a response biomarker such as brain derived neurotrophic factor (BDNF), which we now know is associated with neural plasticity. Purpose: The purpose of this 2-group, double-blind, randomized controlled trial is to test the feasibility, satisfaction, and preliminary efficacy of a computerized home-based cognitive training program compared to attention control in breast cancer survivors (BCS) as well as to explore potential biomarkers of intervention effects. Methods: A total of 68 eligible BCS will be randomized to computerized cognitive training or attention control. A blinded and trained tester will perform data collection and neuropsychological testing at two time points: baseline prior to intervention (T1) and immediately after the 10-week cognitive training -program (+/- 7 days) (T2). Feasibility and satisfaction will be assessed through objective indicators (study adherence, completion rate) and self-report (facilitators, barriers, and perceived satisfaction) and cognitive performance will be assessed through objective neuropsychological tests. In addition, we will measure the effects of cognitive training on self-report measures of perceived cognitive function, associated symptoms (depressive symptoms, anxiety and fatigue), perceived work ability, and quality of life. Data will be analyzed using descriptive statistics and a general linear mixed model (GLMM). Simple main effects analyses will be used to follow up statistically significant interactions. Findings and Conclusions: Preliminary results of this trial will be presented, including an assessment of treatment fidelity measures used in this intervention trial. This work will represent the first rigorous trial of computerized cognitive training delivered in the home to BCS. Positive or negative study findings will provide empirical evidence for cliniciansu2019 recommendations and survivorsu2019 treatment selections for managing cognitive impairment in BCS. Acknowledgement: This work was funded by a grant from the Indiana University School of Nursing, Center for Enhancing Quality of Life (CEQL).
Author: Mahmoud Aljurf Publisher: Springer Nature ISBN: 3030820521 Category : Medical Languages : en Pages : 192
Book Description
This open access book provides a valuable resource for hospitals, institutions, and health authorities worldwide in their plans to set up and develop comprehensive cancer care centers. The development and implementation of a comprehensive cancer program allows for a systematic approach to evidence-based strategies of prevention, early detection, diagnosis, treatment, and palliation. Comprehensive cancer programs also provide a nexus for the running of clinical trials and implementation of novel cancer therapies with the overall aim of optimizing comprehensive and holistic care of cancer patients and providing them with the best opportunity to improve quality of life and overall survival. This book's self-contained chapter format aims to reinforce the critical importance of comprehensive cancer care centers while providing a practical guide for the essential components needed to achieve them, such as operational considerations, guidelines for best clinical inpatient and outpatient care, and research and quality management structures. Intended to be wide-ranging and applicable at a global level for both high and low income countries, this book is also instructive for regions with limited resources. The Comprehensive Cancer Center: Development, Integration, and Implementation is an essential resource for oncology physicians including hematologists, medical oncologists, radiation oncologists, surgical oncologists, and oncology nurses as well as hospitals, health departments, university authorities, governments and legislators.
Author: Robert Ferguson Publisher: Oxford University Press ISBN: 0197521541 Category : Medical Languages : en Pages : 115
Book Description
Cancer-related cognitive impairment (CRCI) may affect nearly half of all cancer survivors and can persist for years after completing cancer treatment. Memory and Attention Adaptation Training (MAAT) is a cognitive-behavioral therapy offering evidence-based, nonpharmacological treatment of this common survivorship condition. Organized into a session-by-session Clinician Manual and related Survivor Workbook, MAAT is conducted in 8 treatment visits and has been demonstrated effective when delivered through telehealth technology, so survivors can readily fit MAAT into their busy lives. The Survivor Workbook starts with a brief overview of what is understood about CRCI, common problems, and how MAAT helps. The introduction is followed by the 8 visits summarized in concise chapters that allow for easy review after the therapy visit. Thus, survivors with memory problems have a reliable source to turn to so that content of visits is not forgotten. Each visit consists of homework exercises with easy to follow forms.
Author: Heather M. Derry Publisher: ISBN: Category : Breast Languages : en Pages : 179
Book Description
Conclusions: There were not consistent, clear links between cognitive function, cardiorespiratory fitness, and chemotherapy/radiation adherence in this sample of relatively healthy, well-adjusted women following breast cancer surgery. Although physical fitness did not appear to benefit cognitive function in this study, breast cancer survivors gain many other health advantages from being physically fit throughout the disease continuum. Increased research focus on the post-surgery period will help to determine the underpinnings of pre-treatment cognitive dysfunction and decreased fitness, as well as characterize the relevance of these problems to clinical and real-world outcomes in breast cancer survivorship.
Author: Monica Castiglione Publisher: Springer Science & Business Media ISBN: 0387751157 Category : Medical Languages : en Pages : 483
Book Description
Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.
Author: Linda Carlson Publisher: New Harbinger Publications ISBN: 1608822354 Category : Health & Fitness Languages : en Pages : 210
Book Description
A Mind-Body Approach to Healing If you have received a cancer diagnosis, you know that the hundreds of questions and concerns you have about what's to come can be as stressful as the cancer treatment itself. But research shows that if you mentally prepare yourself to handle cancer treatment by getting stress and anxiety under control, you can improve your quality of life and become an active participant in your own recovery. Created by leading psychologists specializing in oncology, the Mindfulness-Based Cancer Recovery program is based on mindfulness-based stress reduction (MBSR), a therapeutic combination of mindfulness meditation and gentle yoga now offered to cancer survivors and their loved ones in hundreds of medical centers, hospitals, and clinics worldwide. Let this book be your guide as you let go of fear and focus on getting well. With this eight-week program, you'll learn to: • Use proven MBSR skills during your treatment and recovery • Boost your immune function through meditation and healing yoga • Calm feelings of fear, uncertainty, and lack of control • Mindfully manage difficult symptoms and side effects • Discover your own capacity for healing and thriving after adversity
Author: Katherine R.P. George
Author: Katherine R.P. George
Author: Christina A. Meyers
Author: Adele Deborah Lenae Crouch
Author: Robert Ferguson
Author: Adele Crouch
Author: Mahmoud Aljurf
Author: Robert Ferguson
Author: Heather M. Derry
Author: Monica Castiglione
Author: Linda Carlson