Author: Avik Mukherjee Publisher: ISBN: Category : Cancer Languages : en Pages : 55
Book Description
"The Topors protein is a tumor suppressor in human that associates with and regulates a number of cell cycle regulators that including topoisomerase I and p53. It possesses both ubiquitin and SUMO ligase activity and its mutation or downregulation has been associated with some human cancers and diseases. The Drosophila homologue, dTopors, is an ubiquitin E3 ligase. We have investigated the role of Dtopors in sumoylating proteins in the male germ line. Although nuclear lamin localization is disrupted in dtopors mutants, we find no evidence of lamin modification by Dtopors. We observe an increase in the overall sumoylation of testis proteins and a corresponding decrease in the pool of free SUMO in homozygous dtopors versus heterozygous dtopors flies. Based on this result, we propose a model explaining the role of dtopors in altering germline sumoylation. We have constructed a SUMO-GFP transgenic protein to investigate how dtopors is altering the pool of SUMO in the cell. We demonstrate that this transgenic construct can rescue smt3 mutant flies and is expressed in spermatocytes. This tool will allow one to measure SUMO synthesis and processing, and how these aspects of SUMO dynamics are affected by dtopors during meiosis in D. melanogaster males."--Abstract from author supplied metadata.
Author: Jocelyn E. Krebs Publisher: Jones & Bartlett Learning ISBN: 1284104494 Category : Medical Languages : en Pages : 864
Book Description
Now in its twelfth edition, Lewin's GENES continues to lead with new information and cutting-edge developments, covering gene structure, sequencing, organization, and expression. Leading scientists provide revisions and updates in their individual field of study offering readers current data and information on the rapidly changing subjects in molecular biology.
Author: Jeffrey S. Smith Publisher: Humana ISBN: 9781493951826 Category : Science Languages : en Pages : 0
Book Description
Yeast Genetics: Methods and Protocols is a collection of methods to best study and manipulate Saccharomyces cerevisiae, a truly genetic powerhouse. The simple nature of a single cell eukaryotic organism, the relative ease of manipulating its genome and the ability to interchangeably exist in both haploid and diploid states have always made it an attractive model organism. Genes can be deleted, mutated, engineered and tagged at will. Saccharomyces cerevisiae has played a major role in the elucidation of multiple conserved cellular processes including MAP kinase signaling, splicing, transcription and many others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Yeast Genetics: Methods and Protocols will provide a balanced blend of classic and more modern genetic methods relevant to a wide range of research areas and should be widely used as a reference in yeast labs.
Author: Robert Morgan Publisher: Greatunpublished ISBN: 9781588985019 Category : Poetry Languages : en Pages : 64
Book Description
Available to the public for the first time in decades, Zirconia Poems is the first published book by New York Times best-selling author Robert Morgan, author of Gap Creek, an Oprah Book Club selection.
Author: Benjamin Lewin Publisher: Jones & Bartlett Publishers ISBN: 1449655831 Category : Science Languages : en Pages : 832
Book Description
The Second Edition of Lewin's Essential GENES continues to provide students with the latest findings in the field of molecular biology and molecular genetics. An exceptional new pedagogy enhances student learning and helps readers understand and retain key material like never before. New Concept and Reasoning Checks at the end of each chapter section, End of Chapter Questions and Further Readings for each chapter, and several categories of special topics boxes within each chapter expand and reinforce important concepts. The reorganization of topics in this edition allows students to focus more sharply on the key material at hand and improves the natural flow of course material. New end-of-chapter questions reviews major points in the chapter and allow students to test themselves on important course material. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.
Author: Sharmila Sen Publisher: Penguin ISBN: 0143131389 Category : Biography & Autobiography Languages : en Pages : 225
Book Description
Winner of the ALA Asian/Pacific American Award for Nonfiction "Captivating... [a] heartfelt account of how newcomers carve a space for themselves in the melting pot of America." --Publishers Weekly A first-generation immigrant's "intimate, passionate look at race in America" (Viet Thanh Nguyen), an American's journey into the heart of not-whiteness. At the age of 12, Sharmila Sen emigrated from India to the U.S. The year was 1982, and everywhere she turned, she was asked to self-report her race - on INS forms, at the doctor's office, in middle school. Never identifying with a race in the India of her childhood, she rejects her new "not quite" designation - not quite white, not quite black, not quite Asian -- and spends much of her life attempting to blend into American whiteness. But after her teen years trying to assimilate--watching shows like General Hospital and The Jeffersons, dancing to Duran Duran and Prince, and perfecting the art of Jell-O no-bake desserts--she is forced to reckon with the hard questions: What does it mean to be white, why does whiteness retain the magic cloak of invisibility while other colors are made hypervisible, and how much does whiteness figure into Americanness? Part memoir, part manifesto, Not Quite Not White is a searing appraisal of race and a path forward for the next not quite not white generation --a witty and sharply honest story of discovering that not-whiteness can be the very thing that makes us American.
Author: Alan Cock Publisher: Springer Science & Business Media ISBN: 0387756884 Category : Science Languages : en Pages : 756
Book Description
This biography provides an understanding of William Bateson as well as a reconciliation of diverging views (e.g. the hierarchical thinking of Gould and the genocentrism of George Williams and Richard Dawkins). Evolutionists may thus, at long last, present a unified front to their creationist opponents. The pressing need for this text is apparent from the high percentages reported not to believe in evolution and the growth of the so-called "intelligent design" movement.
Author: Avik Mukherjee
Author: Jocelyn E. Krebs
Author: Jeffrey S. Smith
Author: Robert Morgan
Author: William Glennon
Author: Benjamin Lewin
Author: Bertha Harris
Author: Sharmila Sen
Author: Franklin D. Mitchell
Author: Alan Cock