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Author: Publisher: Professor Dr. Bilal Semih Bozdemir ISBN: Category : Cooking Languages : en Pages : 483
Book Description
The innate immune response serves as the body's first line of defense against pathogens and is a critical player in psoriasis development. Genetic variations influencing the components of the innate immune system, such as keratinocytes, dendritic cells, and macrophages, significantly affect disease mechanisms. Keratinocytes in psoriatic lesions express heightened levels of antimicrobial peptides (AMPs) like cathelicidin and β-defensin, which are tightly regulated by genetic factors. Increased AMP expression can perpetuate inflammation by acting as chemoattractants for immune cells and by triggering pro-inflammatory cytokine production. Moreover, single nucleotide polymorphisms (SNPs) in genes coding for innate immune receptors, such as Toll-like receptors (TLRs), have been associated with increased susceptibility to psoriasis. For instance, genetic variants affecting TLR signaling can lead to an exaggerated inflammatory response to environmental triggers, such as trauma or infections, commonly associated with psoriasis flares. This implicates TLR-mediated pathways as crucial targets for therapeutic intervention, as modulation of this signaling can alter disease progression.
Author: Publisher: Professor Dr. Bilal Semih Bozdemir ISBN: Category : Cooking Languages : en Pages : 483
Book Description
The innate immune response serves as the body's first line of defense against pathogens and is a critical player in psoriasis development. Genetic variations influencing the components of the innate immune system, such as keratinocytes, dendritic cells, and macrophages, significantly affect disease mechanisms. Keratinocytes in psoriatic lesions express heightened levels of antimicrobial peptides (AMPs) like cathelicidin and β-defensin, which are tightly regulated by genetic factors. Increased AMP expression can perpetuate inflammation by acting as chemoattractants for immune cells and by triggering pro-inflammatory cytokine production. Moreover, single nucleotide polymorphisms (SNPs) in genes coding for innate immune receptors, such as Toll-like receptors (TLRs), have been associated with increased susceptibility to psoriasis. For instance, genetic variants affecting TLR signaling can lead to an exaggerated inflammatory response to environmental triggers, such as trauma or infections, commonly associated with psoriasis flares. This implicates TLR-mediated pathways as crucial targets for therapeutic intervention, as modulation of this signaling can alter disease progression.
Author: Professor Dr. Bilal Semih Bozdemir Publisher: Professor Dr. Bilal Semih Bozdemir ISBN: Category : Cooking Languages : en Pages : 483
Book Description
The innate immune response serves as the body's first line of defense against pathogens and is a critical player in psoriasis development. Genetic variations influencing the components of the innate immune system, such as keratinocytes, dendritic cells, and macrophages, significantly affect disease mechanisms. Keratinocytes in psoriatic lesions express heightened levels of antimicrobial peptides (AMPs) like cathelicidin and β-defensin, which are tightly regulated by genetic factors. Increased AMP expression can perpetuate inflammation by acting as chemoattractants for immune cells and by triggering pro-inflammatory cytokine production. Moreover, single nucleotide polymorphisms (SNPs) in genes coding for innate immune receptors, such as Toll-like receptors (TLRs), have been associated with increased susceptibility to psoriasis. For instance, genetic variants affecting TLR signaling can lead to an exaggerated inflammatory response to environmental triggers, such as trauma or infections, commonly associated with psoriasis flares. This implicates TLR-mediated pathways as crucial targets for therapeutic intervention, as modulation of this signaling can alter disease progression.
Author: Nikhil Yawalkar Publisher: Karger Medical and Scientific Publishers ISBN: 3805591519 Category : Medical Languages : en Pages : 205
Book Description
Treatments for psoriasis, besides affecting the skin, may be associated with various comorbidities (for instance, depression, psoriatic arthritis, Crohn's disease and, in severe psoriasis, metabolic syndrome and cardiovascular diseases), which often presents a therapeutic challenge to physicians.Written by renowned experts, this volume gives a comprehensive overview of psoriasis and its various comorbidities. It describes the treatment modalities for mild and moderate-to-severe psoriasis, including topical, phototherapeutic and conventional systemic treatments (e.g. acitretine, methotrexate and cyclosporine), as well as biological therapies (e.g. alefacept, efalizumab, etanercept, adalimumab and infliximab). The chapters on biological therapies focus on key safety issues. Further chapters focus on such topics as the management of childhood psoriasis and psoriasis in distinctive locations, such as the scalp, face, flexures, palm/soles and nails. Finally, future therapeutic modalities, with the focus on small molecules and potential biological therapies, are discussed.This publication will make significant reading to dermatologists and all physicians dealing with psoriasis, such as general practitioners, psychiatrists, rheumatologists, cardiologists and diabetologists.
Author: Professor Dr. Bilal Semih Bozdemir Publisher: Professor Dr. Bilal Semih Bozdemir ISBN: Category : Medical Languages : en Pages : 415
Book Description
Regional variations in psoriasis patterns are hypothesized to reflect genetic factors contributing to differential immune responses. Such differences can manifest in disease severity, presentation, and treatment response. For example, certain geographic populations may exhibit unique genetic markers associated with specific immune responses, providing insight into the regional manifestations of psoriasis. Variations in environmental exposures, cultural practices, and lifestyle factors, when combined with genetic susceptibility, may further stratify disease expression across different cohorts, offering a multifactorial perspective on the disease. A particular interest lies in understanding how environmental factors, such as UV exposure and humidity, interact with genetic predispositions to influence immune responses. Studies suggest that environmental exposures can amplify or potentially mitigate genetic susceptibility to psoriasis, emphasizing the importance of considering both genetic and environmental factors in deciphering the complexities of psoriasis pathology. 7. Translational Implications: From Genetics to Therapeutics Understanding the immunological mechanisms mediated by genetic factors holds considerable promise for advancing therapeutic options in psoriasis. Targeted biologics that inhibit specific cytokines implicated in the pathogenic processes of psoriasis have transformed the treatment landscape. For instance, biologics targeting IL-17A, IL-23, and TNF-α have demonstrated efficacy in managing moderate to severe psoriasis, providing an avenue for personalized treatment approaches based on individual genetic profiles. Moreover, as research advances, the potential for precision medicine approaches to address the genetic underpinnings of immune dysregulation in psoriasis expands. Identifying specific genotypes predictive of treatment response could lead to more effective interventions, optimizing outcomes for individuals across diverse populations and regions.Regional Variations of Psoriasis - Volume - III
Author: Professor Dr. Bilal Semih Bozdemir Publisher: Professor Dr. Bilal Semih Bozdemir ISBN: Category : Medical Languages : en Pages : 415
Book Description
Genome-wide association studies (GWAS) have identified numerous genetic loci associated with psoriasis, revealing a complex interplay between genetic architecture and immunological mechanisms. Many identified loci are involved in immune pathways, reinforcing the linkage between genetic predisposing variants and immune dysregulation. Notably, loci that harbor variants influencing key immunological pathways, including Th17 and IL-23 signaling pathways, are particularly prominent among patients with psoriasis. These findings not only underscore the role of specific gene variants in influencing immune responses but also highlight the potential for targeted therapies that address these genetic predispositions. By understanding the genetic landscape underpinning immune dysregulation, clinicians can develop more effective treatment strategies tailored to individual genetic profiles and regional patterns of psoriasis.
Author: Diane Jackson-Richards Publisher: Springer ISBN: 3642544460 Category : Medical Languages : en Pages : 300
Book Description
This atlas, containing more than 300 color photos, focuses on those dermatologic conditions that are most common in ethnic skin or skin of color. It includes succinct explanations of each disease process, describes clinical findings and presents key information on diagnosis and treatment. Individual chapters are devoted to pigmentary disorders, follicular disorders, hair and scalp disorders, eczemas, papulosquamous disorders, granulomatous disorders, connective tissue diseases, infectious diseases, scarring disorders, cutaneous neoplasms, photodermatoses and drug eruptions. The fact that this atlas covers skin disorders that affect patients of all ethnic backgrounds ensures that it will be of worldwide relevance. It will serve as a valuable reference for dermatologists and a range of other health care providers.
Author: E. Carstens Publisher: CRC Press ISBN: 1466505435 Category : Science Languages : en Pages : 482
Book Description
Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Author: John Koo Publisher: CRC Press ISBN: 0429585985 Category : Medical Languages : en Pages : 422
Book Description
Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis
Author: Wilma Lambert Publisher: Nova Science Publishers ISBN: 9781634856492 Category : Psoriasis Languages : en Pages : 0
Book Description
Psoriasis is a common, non-infectious, chronic inflammatory skin disease characterised by distinctive erythematous plaques that multiply and scale over with silvery patches. Psoriasis can affect any cutaneous site and is frequently found on the extensor skin surface of elbows and knees, scalp and sacral regions. Psoriasis is also associated with systemic conditions, including psoriatic arthritis, Crohns disease and lymphoma. This book discusses the epidemiology, diagnosis and management strategies of psoriasis. Chapter One provides an overview of the challenging medical condition. Chapter Two discusses the possible factors raised by literature as main contributors to sleep disturbances and its correlation to psoriasis. Chapter Three gives an overview of the current results where blood plasma thermal changes have been detected by Differential Scanning Calorimetry (DSC) technique on psoriatic patients with different clinical stages, and monitored patients with no symptoms to patients with serious symptoms. Chapter Four discusses psoriasis treatment that targets the IL-23/Th17 axis. Chapter Five reviews natural health products for managing psoriasis.
Author: World Health Organization Publisher: ISBN: 9789241565189 Category : Medical Languages : en Pages : 0
Book Description
This WHO Global report on psoriasis brings the public health impact of psoriasis into focus. The report is written to help raise awareness of the range of ways that psoriasis can affect peoples' lives. It intends to empower policy-makers with practical solutions to improve the health care and social inclusion of people living with psoriasis in their populations. The report highlights that much of the suffering caused by this common and complex disease can be avoided. Improving access to early diagnosis and appropriate treatment for psoriasis requires universally accessible health-care systems that provide people-centered care for patients with complex, lifelong conditions. Governments also have a key role to play in seeking to address the unnecessary social consequences of psoriasis by the challenging the myths and behaviors that lead to the exclusion of patients from healthcare settings and daily life.
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Author: 
Author: Professor Dr. Bilal Semih Bozdemir
Author: Nikhil Yawalkar
Author: Professor Dr. Bilal Semih Bozdemir
Author: Professor Dr. Bilal Semih Bozdemir
Author: Diane Jackson-Richards
Author: E. Carstens
Author: John Koo
Author: Wilma Lambert
Author: World Health Organization