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Author: Lewis Wolpert Publisher: Oxford University Press ISBN: 0199601194 Category : Science Languages : en Pages : 153
Book Description
"A concise account of what we know about development discusses the first vital steps of growth and explores one of the liveliest areas of scientific research."--P. [2] of cover.
Author: Lewis Wolpert Publisher: Oxford University Press ISBN: 0199601194 Category : Science Languages : en Pages : 153
Book Description
"A concise account of what we know about development discusses the first vital steps of growth and explores one of the liveliest areas of scientific research."--P. [2] of cover.
Author: Andrew Tallon Publisher: Routledge ISBN: 1135278482 Category : Political Science Languages : en Pages : 335
Book Description
Exploring the streets of London, Manchester, Belfast, Edinburgh or Cardiff, one cannot help but notice the striking transformations taking place in the urban landscapes. This prominent regeneration of urban areas in the UK and around the world has become an increasingly important issue amongst governments and populations. The growing concern has been a result of the impacts of the decline of cities since the collapse of manufacturing industries and the heightening of global competition. A range of innovative approaches to tackle urban problems have been taken over many decades to attempt to regenerate the fortunes of towns and cities across the UK. This text provides an accessible, yet critical, synthesis of urban regeneration in the UK incorporating key policies, approaches, issues and debates. The central objective of the book is to place the historical and contemporary regeneration agenda into context. Section one sets up the conceptual and policy framework for urban regeneration in the UK. SectiontTwo traces policies that have been adopted by central government to influence the social, economic and physical development of cities, including early municipal interventions in the late nineteenth century, community-focused urban policies of the late 1960s, entrepreneurial property-led regeneration of the 1980s and competition for urban funds in the 1990s. The penultimate section illustrates the key thematic policies and strategies that have been pursued by cities themselves, focusing particularly on improving economic competitiveness and tackling social disadvantage. These approaches are contextualized by discussions covering, for example, urban competitiveness policies and the focus on sustainable urban regeneration. The final section summarizes key issues and debates facing urban regeneration, and speculates upon future directions. Urban Regeneration in the UK blends the approaches taken by central government programmes and cities themselves in the regeneration process. The latest ideas and examples from across disciplines and across the UK’s urban areas are illustrated. This book provides a comprehensive and up-to-date synthesis that will fill a significant gap in the current literature on regeneration and will be a tool for students as well as a seminal read for practitioners and researchers.
Author: Bruce M. Carlson Publisher: Elsevier ISBN: 0080477968 Category : Science Languages : en Pages : 400
Book Description
With the explosion of knowledge from molecular biology and the burgeoning interest in generating or regenerating tissues or organs through various bioengineering or stem cell approaches, many scientists and students have shown a renewed interest in the phenomenon of regeneration. Because relatively few have had the luxury of being able to approach the phenomenon of regeneration from a broad biological perspective, Dr. Carlson has produced a book that outlines the fundamental principles of regeneration biology. Subject matters focus principally on regeneration in vertebrate systems, but also invertebrate regeneration. In order to manipulate regenerative processes, it is important to understand the underlying principles of regeneration. Principles of Regnerative Biology is the key introductory reference for all developmental biologists, geneticists, and tissue and stem cell researchers. - Creates a general understanding of one of the most fascinating and complex phenomena in biology - Discusses the ability and diversity of regeneration in various organisms - Explains the history and origins of cells in regenerating systems - Includes information on stem cells and its important role in regeneration
Author: Jochen C. Rink Publisher: Humana ISBN: 9781493978007 Category : Science Languages : en Pages : 0
Book Description
This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.
Author: Ellen Heber-Katz Publisher: Springer Science & Business Media ISBN: 3642358101 Category : Medical Languages : en Pages : 280
Book Description
Regeneration, the homeostatic ability to maintain tissue structure in the face of normal cell turnover or loss of tissue damaged by trauma or disease, is an essential developmental process that continues throughout life. As recently as a decade ago, any serious discussion of the possibility of regeneration becoming a practical medical tool in the near future had the air of science fiction or over-optimistic speculation. The term “regenerative medicine” was certainly on many lips but few actually expected to soon see it applied in a clinical setting. A tidal wave of discovery has changed that and investigating the cellular mechanisms of natural regeneration has become one of the hottest topics in developmental biology and biomedicine in general. Many researchers entering the field find that the regeneration literature is still quite diffuse perhaps owing to the disparate biological systems that have been the object of study including hydra, planaria, newts, axolotls and more recently several mouse strains. The volume editors believe that an attempt to organize or systematize the literature is long overdue. In this volume, respected experts highlight the latest findings in vertebrate (including mammals) wound healing and regeneration. They present eleven reviews that cover a wide range of topics, from wound repair and its relationship to regeneration, through systems including lenticular, neural, and musculoskeletal tissues and limbs, to epigenetics and the role of the cell cycle. Nuclear reprogramming and cellular plasticity, which open the door for potential regenerative medical therapies for injury and degenerative disease, are recurring themes throughout the book. We are all now part of the regeneration revolution.
Author: David L. Stocum Publisher: Academic Press ISBN: 012384861X Category : Technology & Engineering Languages : en Pages : 474
Book Description
Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. - Highly Commended 2013 BMA Medical Book Award for Medicine - Includes coverage of skin, hair, teeth, cornea, and central neural tissues - Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems - Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals
Author: Helen Sink Publisher: Springer Science & Business Media ISBN: 0387329633 Category : Science Languages : en Pages : 214
Book Description
The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
Author: Lorenzo Alibardi Publisher: Springer Science & Business Media ISBN: 364203733X Category : Medical Languages : en Pages : 117
Book Description
The present review covers a very neglected field in regeneration studies, namely, tissue and organ regeneration in reptiles, especially represented by the lizard model of regeneration. The term “regeneration” is intended here as “the ability of an adult organism to recover damaged or completely lost body parts or organs.” The process of recovery is further termed “restitutive regeneration” when the lost part is reformed and capable of performing the complete or partial physiological activity performed by the original, lost body part. Lizards represent the only amniotes that at the same time show successful organ regeneration, in the tail, and organ failure, in the limb (Marcucci 1930a, b; Simpson 1961, 1970, 1983). This condition offers a unique opportunity to study at the same time mechanisms that in different regions of the same animal control the success or failure of regeneration. The lizard model is usually neglected in the literature despite the fact that the lizard is an amniote with a basic histological structure similar to that of mammals, and it is therefore a better model than the salamander (an a- mniote) model to investigate regeneration issues.
Author: Heinz Redl Publisher: Springer ISBN: 9783319088303 Category : Technology & Engineering Languages : en Pages : 0
Book Description
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
Author: Lewis Wolpert
Author: Lewis Wolpert
Author: Andrew Tallon
Author: Bruce M. Carlson
Author: Jochen C. Rink
Author: Jennifer R Morgan
Author: Ellen Heber-Katz
Author: David L. Stocum
Author: Helen Sink
Author: Lorenzo Alibardi
Author: Heinz Redl