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Author: A. V. Hoffbrand Publisher: ISBN: 9783805593120 Category : Iron Languages : en Pages : 0
Book Description
There has been a remarkable increase in the understanding of iron absorption, metabolism and cellular homeostasis due to the discovery of a wide range of proteins involved in these processes. Pioneered in the USA by Propper's group, effective iron chelation therapy by subcutaneous desferrioxamine has become a standard for transfusional iron overload. The development of the T2 * MRI technique by Dudley Pennell then fulfilled the need for a non-invasive reproducible technique for measuring cardiac iron. The most common anaemia in the world still remains iron deficiency. Ernest Beutler's (1928-2008) investigations on genetic haemochromatosis have been critical in the understanding of genotypic/phenotypic relations in this disease. This special issue of Acta Haematologica is dedicated to him and his extraordinary work in basic and clinical research on iron, as well as in many other areas of medicine. With contributions by clinical scientists who have made major steps to our understanding of iron metabolism and the mechanisms and treatment of iron-related diseases, it will be a great resource for haematologists in the field.
Author: A. V. Hoffbrand Publisher: ISBN: 9783805593120 Category : Iron Languages : en Pages : 0
Book Description
There has been a remarkable increase in the understanding of iron absorption, metabolism and cellular homeostasis due to the discovery of a wide range of proteins involved in these processes. Pioneered in the USA by Propper's group, effective iron chelation therapy by subcutaneous desferrioxamine has become a standard for transfusional iron overload. The development of the T2 * MRI technique by Dudley Pennell then fulfilled the need for a non-invasive reproducible technique for measuring cardiac iron. The most common anaemia in the world still remains iron deficiency. Ernest Beutler's (1928-2008) investigations on genetic haemochromatosis have been critical in the understanding of genotypic/phenotypic relations in this disease. This special issue of Acta Haematologica is dedicated to him and his extraordinary work in basic and clinical research on iron, as well as in many other areas of medicine. With contributions by clinical scientists who have made major steps to our understanding of iron metabolism and the mechanisms and treatment of iron-related diseases, it will be a great resource for haematologists in the field.
Author: Robert Crichton Publisher: John Wiley & Sons ISBN: 1118925637 Category : Medical Languages : en Pages : 576
Book Description
Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.
Author: Publisher: ScholarlyEditions ISBN: 1464938652 Category : Medical Languages : en Pages : 49
Book Description
Iron Metabolism Disorders: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Iron Metabolism Disorders in a concise format. The editors have built Iron Metabolism Disorders: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Iron Metabolism Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Iron Metabolism Disorders: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Yan-Zhong Chang Publisher: ISBN: 9789811395901 Category : Central nervous system Languages : en Pages :
Book Description
This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.
Author: Publisher: ScholarlyEditions ISBN: 1481609009 Category : Medical Languages : en Pages : 74
Book Description
Iron Metabolism Disorders—Advances in Research and Treatment: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Iron Metabolism Disorders in a concise format. The editors have built Iron Metabolism Disorders—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Iron Metabolism Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Iron Metabolism Disorders—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Shlomo Yehuda Publisher: Springer Science & Business Media ISBN: 1597454621 Category : Medical Languages : en Pages : 377
Book Description
Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.
Author: Chaim Hershko Publisher: Springer Science & Business Media ISBN: 1461525543 Category : Science Languages : en Pages : 394
Book Description
The 4th International Conference on Hemochromatosis and the 11th International Conference on Iron and Iron Proteins took place in Jerusalem on April 27 -30 and on May 2 -7 1993, respectively. The first, a clinical meeting, and the second, a forum designed primarily for basic scientists. Both meetings are held regularly on alter nate years and represent probably the most important forum for the exchange of information in iron research. The present volume "Progress in Iron Research" is based on a selection of presentations delivered at these meetings. However, this volume represents much more than a publication of conference proceedings. It offers a comprehensive state-of-the-art review on most aspects of iron metabolism. We have tried to offer a balanced review of the most important recent developments in iron research including both basic research and clinical investigation. However, the scope of chapters was based, by definition, on the actual participants at the meetings and some important fields in iron research such as plant physiology, microbial aspects of iron metabolism, and free radical research have not been dealt with. Many of the authors of the 40 chapters have beel). pt1rsonally responsible for some of the most important developments in iron research ~~vidffig: n~~~ights into iron physiology and pathophysiology. The Editors wish to express their gratitude for the outstanding and timely cooperation of all contributors to this volume.
Author: Sarika Arora Publisher: BoD – Books on Demand ISBN: 9535106058 Category : Medical Languages : en Pages : 198
Book Description
Iron has various functions in the body, including the metabolism of oxygen in a variety of biochemical processes. Iron, as either heme or in its "nonheme" form, plays an important role in key reactions of DNA synthesis and energy production. However, low solubility of iron in body fluids and the ability to form toxic hydroxyl radicals in presence of oxygen make iron uptake, use and storage a serious challenge. The discovery of new metal transporters, receptors and peptides and as well as the discovery of new cross-interactions between known proteins are now leading to a breakthrough in the understanding of systemic iron metabolism. The objective of this book is to review and summarize recent developments in our understanding of iron transport and storage in living systems.
Author: Jeremy H. Brock Publisher: Bailliere Tindall Limited ISBN: Category : Medical Languages : en Pages : 512
Book Description
An overview of human iron metabolism. This book reviews the metabolic importance of iron in evolution, the physiology and biochemistry of internal iron exchange, iron absorption and iron storage, the molecular regulation of cellular iron homeostasis and aspects of iron and disease.
Author: Dominique Expert Publisher: Springer Science & Business Media ISBN: 9400752660 Category : Science Languages : en Pages : 91
Book Description
Iron plays a key role in biology as essential cofactor of numerous proteins. However, since it is only slightly soluble its bioavailability can be readily compromised under aerobic conditions. Moreover, due to its ability to catalyze the generation of free radicals, iron can also be toxic. Thus, it doesn’t surprise that living organisms have developed sophisticated means for acquiring iron whilst tightly controlling the intracellular concentrations of this metal in response to environmental conditions. Also, the critical role of iron has long been acknowledged in host vertebrate-parasite relationships where both partners compete for the acquisition of this essential element and activate complex signaling cascades to control their iron homeostasis during infection. Following the great interest that the mechanisms regulating the acquisition of iron and the control of iron homeostasis have generated among researchers studying plant-pathogen and legume-rhizobia interactions, this book offers a comprehensive analysis of irons’ various roles in the plant-microbial associations. The introductory chapter stresses the essentiality of iron in biological systems. The second chapter surveys the abundance of information on iron’s pivotal role in microbial plant pathogenesis and defence. Finally, the third chapter reviews the advances in our understanding of iron metabolism in the rhizobia, soil bacteria able to establish a symbiotic association with legumes and carry out nitrogen fixation. Molecular Aspects of Iron Metabolism in Pathogenic and Symbiotic Plant-Microbe Associations is a valuable resource to microbiologists, pathologists and scientists interested in iron uptake and metabolism in microbial pathogenesis, rhizobia legume associations, and plant physiology and immunity.
Author: A. V. Hoffbrand
Author: A. V. Hoffbrand
Author: Robert Crichton
Author: 
Author: Yan-Zhong Chang
Author: 
Author: Shlomo Yehuda
Author: Chaim Hershko
Author: Sarika Arora
Author: Jeremy H. Brock
Author: Dominique Expert