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Author: Attila Gacser Publisher: Frontiers Media SA ISBN: 2889450627 Category : Languages : en Pages : 150
Book Description
Fungal infections represent nowadays a significant burden on the healthcare system of most of the countries, and are among the infections with the highest mortality rates. This has fostered the study of the interaction of these organisms with the human host. The outer most layer of a fungal cell is the cell wall, and together with the secreted components into the extracellular compartment, are the first lines of contact with the host cells. This interaction is critical for tissue adhesion, colonization and damage. In addition, these fungal extracellular components will define the outcome of the interaction with the host immune cells, leading either to the establishment of a protective antifungal immune response or to an immune-evasive mechanism by the fungal cell. On the other hand, our immune system has effectively evolved to deal with fungal pathogens, developing strategies for cell eradication, burden control, or antigen presentation from the innate branch to the adaptive immune response. Here, we provide a series of comprehensive review papers dealing with both aspect of the interaction fungus-immune cells: the role of virulence factors and cell wall components during such interaction, and the recent advances in the study of cellular receptors in the establishment of a protective anti-fungal immune response.
Author: Attila Gacser Publisher: Frontiers Media SA ISBN: 2889450627 Category : Languages : en Pages : 150
Book Description
Fungal infections represent nowadays a significant burden on the healthcare system of most of the countries, and are among the infections with the highest mortality rates. This has fostered the study of the interaction of these organisms with the human host. The outer most layer of a fungal cell is the cell wall, and together with the secreted components into the extracellular compartment, are the first lines of contact with the host cells. This interaction is critical for tissue adhesion, colonization and damage. In addition, these fungal extracellular components will define the outcome of the interaction with the host immune cells, leading either to the establishment of a protective antifungal immune response or to an immune-evasive mechanism by the fungal cell. On the other hand, our immune system has effectively evolved to deal with fungal pathogens, developing strategies for cell eradication, burden control, or antigen presentation from the innate branch to the adaptive immune response. Here, we provide a series of comprehensive review papers dealing with both aspect of the interaction fungus-immune cells: the role of virulence factors and cell wall components during such interaction, and the recent advances in the study of cellular receptors in the establishment of a protective anti-fungal immune response.
Author: Institute of Medicine Publisher: National Academies Press ISBN: 030921226X Category : Medical Languages : en Pages : 488
Book Description
Fungal diseases have contributed to death and disability in humans, triggered global wildlife extinctions and population declines, devastated agricultural crops, and altered forest ecosystem dynamics. Despite the extensive influence of fungi on health and economic well-being, the threats posed by emerging fungal pathogens to life on Earth are often underappreciated and poorly understood. On December 14 and 15, 2010, the IOM's Forum on Microbial Threats hosted a public workshop to explore the scientific and policy dimensions associated with the causes and consequences of emerging fungal diseases.
Author: Joginder Singh Panwar Publisher: Elsevier ISBN: 0128226234 Category : Technology & Engineering Languages : en Pages : 328
Book Description
New and Future Developments in Microbial Biotechnology and Bioengineering: Recent Advances in Application of Fungi and Fungal Metabolites: Biotechnological Interventions and Futuristic Approaches is an invaluable resource for researchers planning to work in applied biotechnological interventions and futuristic approaches to fungi and fungal metabolite utilization. Special emphasis is placed on new research relating to fungal-based recombinant DNA technology and genomics analysis which place yeasts and filamentous fungi at the forefront of various contemporary commercial applications. Written in an easy-to-follow language by active researchers, the book presents cutting-edge fungal biotechnological applications in a manner that is accessible to all. - Introduces recent biotechnological interventions and futuristic approaches to fungi and their metabolites - Elaborates on perspectives and diverse applications of harnessing the potential of fungi and fungal metabolites in biotechnology - Describes traditional uses and modern practices of accessing the potential of fungi and their metabolites in solving future needs
Author: Sabine Fillinger Publisher: Springer ISBN: 3319233718 Category : Science Languages : en Pages : 488
Book Description
The fungal genus Botrytis is the focus of intensive scientific research worldwide. The complex interactions between this pathogen and the plants it infects and the economic importance of the diseases caused by Botrytis (principally grey mould) on more than 1400 species of cultivated plants pre- and post-harvest, render this pathogen of particular interest to farmers, advisers, students and researchers in many fields worldwide. This 20-chapter book is a comprehensive treatise covering the rapidly developing science of Botrytis and reflecting the major developments in studies of this fungus. It will serve as a source of general information for specialists in agriculture and horticulture, and also for students and scientists interested in the biology of this fascinating, multifaceted phytopathogenic fungal species.
Author: Joseph Heitman Publisher: John Wiley & Sons ISBN: 1555819583 Category : Medical Languages : en Pages : 1161
Book Description
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
Author: M. Pilar Francino Publisher: Frontiers Media SA ISBN: 2889450155 Category : Languages : en Pages : 276
Book Description
Traditionally, symbiosis research has been undertaken by researchers working independently of one another and often focused on a few cases of bipartite host-symbiont interactions. New model systems are emerging that will enable us to fill fundamental gaps in symbiosis research and theory, focusing on a broad range of symbiotic interactions and including a variety of multicellular hosts and their complex microbial communities. In this Research Topic, we invited researchers to contribute their work on diverse symbiotic networks, since there are a large variety of symbioses with major roles in the proper functioning of terrestrial or aquatic ecosystems, and we wished the Topic to provide a venue for communicating findings across diverse taxonomic groups. A synthesis of recent investigations in symbiosis can impact areas such as agriculture, where a basic understanding of plant-microbe symbiosis will provide foundational information on the increasingly important issue of nitrogen fixation; climate change, where anthropogenic factors are threatening the survival of marine symbiotic ecosystems such as coral reefs; animal and human health, where unbalances in host microbiomes are being increasingly associated with a wide range of diseases; and biotechnology, where process optimization can be achieved through optimization of symbiotic partnerships. Overall, our vision was to produce a volume of works that will help define general principles of symbiosis within a new conceptual framework, in the road to finally establish symbiology as an overdue central discipline of biological science.
Author: Héctor M. Mora-Montes Publisher: Springer ISBN: 3319641131 Category : Science Languages : en Pages : 431
Book Description
Infections caused by fungi have recently attracted the attention of both clinicians and basic researchers given the heavy burden they represent for any health system. The mortality and morbidity rates associated to mycosis are progressively rising simply because some of these diseases are still neglected by health-care workers and due to the changing sensitivity to antifungal drugs displayed by these organisms. In this book, both researchers and clinicians working in the medical mycology field explore the most recent literature about specific mycosis; placing in one concise chapter thoroughly revisions of the current knowledge on virulence factors, recognition by immune cells, immunoevasion, epidemiology, new diagnosis trends and therapeutics. This book is recommended to researchers, physicians and students interested in medical mycology.
Author: Marc Maresca Publisher: MDPI ISBN: 3038424706 Category : Mathematics Languages : en Pages : 299
Book Description
Mycotoxins are secondary metabolites produced by molds. Although the primary role of these toxins is thought to be related to the colonisation of the environment by the fungi--mycotoxins are able to kill other micro-organisms (antimicrobial effect) and/or plant cells (mycotoxin-producing fungi being necrophagic)--the exposure of animals and humans to mycotoxins through the consumption of mycotoxin-contaminated food and feeds leads to diseases and death. Among the different mycotoxins described (more than 350 mycotoxins have been identified), deoxynivalenol (DON or vomitoxin) produced by Fusarium species has attracted the most attention due to its prevalence and toxicity. DON is part of a family of mycotoxins called trichothecenes that are small sesquiterpenoids with an epoxide group at positions 12-13 allowing their binding to ribosomes causing the so-called ribosome stress response, characterized by the activation of various protein kinases that lead to alterations in gene expression and cellular toxicity in animals, humans and plants. Here, we compiled very recent findings regarding DON and its derivatives: i) their prevalence in human food; ii) the estimation of the exposure of humans to them using biological markers; iii) their roles during plant-fungi interaction; iv) the alteration caused by them in animals and humans, particularly at low doses that are close to those observed in farm animals and human consumers; v) possible strategies to decrease their presence in food and feeds. Overall, this book will give the reader a clear and global view on this important mycotoxin produced by Fusarium species which is responsible for huge economic loss and health issues. Dr. Marc Maresca Guest Editor
Author: Archana Singh Publisher: Springer ISBN: 9811073716 Category : Science Languages : en Pages : 367
Book Description
The book offers an integrated overview of plant–pathogen interactions. It discusses all the steps in the pathway, from the microbe–host-cell interface and the plant’s recognition of the microbe to the plant’s defense response and biochemical alterations to achieve tolerance / resistance. It also sheds light on the classes of pathogens (bacteria, fungus and viruses); effector molecules, such as PAMPs; receptor molecules like PRRs and NBS-LRR proteins; signaling components like MAPKs; regulatory molecules, such as phytohormones and miRNA; transcription factors, such as WRKY; defense-related proteins such as PR-proteins; and defensive metabolites like secondary metabolites. In addition, it examines the role of post-genomics, high-throughput technology (transcriptomics and proteomics) in studying pathogen outbreaks causing crop losses in a number of plants. Providing a comprehensive picture of plant-pathogen interaction, the updated information included in this book is valuable for all those involved in crop improvement.
Author: Attila Gacser
Author: Attila Gacser
Author: 
Author: Institute of Medicine
Author: Joginder Singh Panwar
Author: Sabine Fillinger
Author: Joseph Heitman
Author: M. Pilar Francino
Author: Héctor M. Mora-Montes
Author: Marc Maresca
Author: Archana Singh