Recent Advances in Mitocondrial Medicine and Coenzyme Q10 PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Recent Advances in Mitocondrial Medicine and Coenzyme Q10 PDF full book. Access full book title Recent Advances in Mitocondrial Medicine and Coenzyme Q10 by Anna Gvozdjáková. Download full books in PDF and EPUB format.
Author: Anna Gvozdjáková Publisher: ISBN: 9781536131499 Category : Mitochondrial pathology Languages : en Pages : 0
Book Description
Recent Advances in Mitochondrial Medicine and Coenzyme Q10 (eds. Anna Gvozdjáková, Germaine Cornélissen, Ram B Singh) is an updated version of a book Mitochondrial Medicine (ed. A. Gvozdjáková) published by Springer, The Netherlands, in 2008. International contributors and world specialists in Mitochondrial Medicine and Coenzyme Q10 provide up-to-date knowledge in mitochondrial physiology, and review the role played by mitochondria in relation to diseases, diagnosies and therapies pertinent to various fields of medicine. This monograph covers topics related to mitochondrial physiology, mitochondrial sirtuins, supercomplexes, chronobiology, epigenetics, genetics, neurology, cardiology, nephrology, immunology, diabetology, oncology, and reproductive medicine. A chapter on the history of coenzyme Q10 focuses on the work of Prof. Frederick L Crane, discoverer of coenzyme Q10, who died in 2015. Current diagnostic methods of mitochondrial disturbances are reviewed, including a new non-invasive approach using high-resolution respirometry in human blood cells. The effectiveness of supplementary therapies of mitochondrial disturbances is examined for the case of natural antioxidants, melatonin, high protein diet, omega-3-PUFA, omega-6-PUFA, natural mineral water sources and polarized light. Targeting mitochondrial therapy involves coenzyme Q10 (ubiquinone, ubiquinol), prospective mitochondrial replacement therapy and mitochondrial transplantation. This book is intended for general medical practitioners and specialists in various fields of medicine, including neurologists, cardiologists, geneticists, nephrologists, diabetologists, lipidologists, immunologists, oncologists, pharmacists, biochemists and nutritionists. Pre- and post-graduate education physicians, pharmacists and biochemists will also benefit from material covered in this monograph.
Author: Anna Gvozdjáková Publisher: ISBN: 9781536131499 Category : Mitochondrial pathology Languages : en Pages : 0
Book Description
Recent Advances in Mitochondrial Medicine and Coenzyme Q10 (eds. Anna Gvozdjáková, Germaine Cornélissen, Ram B Singh) is an updated version of a book Mitochondrial Medicine (ed. A. Gvozdjáková) published by Springer, The Netherlands, in 2008. International contributors and world specialists in Mitochondrial Medicine and Coenzyme Q10 provide up-to-date knowledge in mitochondrial physiology, and review the role played by mitochondria in relation to diseases, diagnosies and therapies pertinent to various fields of medicine. This monograph covers topics related to mitochondrial physiology, mitochondrial sirtuins, supercomplexes, chronobiology, epigenetics, genetics, neurology, cardiology, nephrology, immunology, diabetology, oncology, and reproductive medicine. A chapter on the history of coenzyme Q10 focuses on the work of Prof. Frederick L Crane, discoverer of coenzyme Q10, who died in 2015. Current diagnostic methods of mitochondrial disturbances are reviewed, including a new non-invasive approach using high-resolution respirometry in human blood cells. The effectiveness of supplementary therapies of mitochondrial disturbances is examined for the case of natural antioxidants, melatonin, high protein diet, omega-3-PUFA, omega-6-PUFA, natural mineral water sources and polarized light. Targeting mitochondrial therapy involves coenzyme Q10 (ubiquinone, ubiquinol), prospective mitochondrial replacement therapy and mitochondrial transplantation. This book is intended for general medical practitioners and specialists in various fields of medicine, including neurologists, cardiologists, geneticists, nephrologists, diabetologists, lipidologists, immunologists, oncologists, pharmacists, biochemists and nutritionists. Pre- and post-graduate education physicians, pharmacists and biochemists will also benefit from material covered in this monograph.
Author: Anna Gvozdjáková Publisher: Springer Science & Business Media ISBN: 1402067143 Category : Medical Languages : en Pages : 446
Book Description
Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.
Author: Lawrence H. Lash Publisher: Elsevier ISBN: 1483218619 Category : Science Languages : en Pages : 527
Book Description
Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.
Author: Roberto Scatena Publisher: Springer Science & Business Media ISBN: 9400728689 Category : Medical Languages : en Pages : 459
Book Description
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
Author: Roberto Scatena Publisher: Springer Science & Business Media ISBN: 9400728697 Category : Medical Languages : en Pages : 459
Book Description
Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of ‘mitochondrial medicine’, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called “mitoxicants” are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.
Author: Publisher: BoD – Books on Demand ISBN: 1789239192 Category : Medical Languages : en Pages : 420
Book Description
Antioxidants are substances that can prevent or slow damage to living cells caused by free radicals, which are unstable molecules the body produces as a reaction to environmental and other pressures. Sometimes called “free-radical scavengers,” free radicals can cause mutation in different biological compounds such as protein, nucleic acids, and lipids, which lead to various diseases (cancer, cardiovascular disease, aging, etc.). Healthy foods are considered a main source of antioxidant compounds and from the beginning of a person’s life, a strong relationship is seen between antioxidant compounds and the prevention of certain diseases, such as types of inflammations, cardiovascular diseases, and different kinds of cancers. It is thus of great importance that new data relating to antioxidants and their biological activity be collected and that antioxidant modes of action be illustrated.Experts from around the world contributed to the current book, discussing antioxidant sources, modes of action, and their relation to human diseases. Twenty-five chapters are presented in two sections: Antioxidants: Sources and Modes of Action and Antioxidants Compounds and Diseases.
Author: Manfred Lamprecht Publisher: CRC Press ISBN: 1466567570 Category : Medical Languages : en Pages : 304
Book Description
The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.
Author: John B. Lombardini Publisher: Springer Science & Business Media ISBN: 146150077X Category : Science Languages : en Pages : 574
Book Description
The Taurine Symposium- "Taurine: Beginning the 21'' Century"- was held September 20-23, 2002, on the beautiful island of Kauai in Hawaii. The headquarters of the meeting was the Radisson Kauai Beach Resort. This international meeting was attending by approximately 80 individuals from 23 nations and 4 continents. Seventy-five papers were presented either as platform presentations or poster presentations. Taurine, first isolated from ox bile in 1827 by Tiedemann and Gmelin and named in 1838 by Demarcay, became of significant scientific interest in 1968 when the first extensive review article was published by Jacobsen and Smith. Interest in taurine grew exponentially after 1975 when the first taurine symposium was organized by Ryan Huxtable in Tucson, Arizona. Since that date, taurine symposia have been held approximately every two years held in various cities and resort areas around the world. Taurine investigators have had the privilege of attending these scientific meetings on three continents - Asia, Europe, and North America. Since the initial meeting in 1975, a central question addressed during many of the symposia has been: "What is physiological, pharmacological, nutritional, and pathological role of taurine?". Although taurine has been established as an important osmolyte, it appears to affect many other biological processes. However, the exact mechanism(s) by "which taurine acts" has not yet been definitively answered. In Kauai, the patticipants discussed many topics and asked many questions regarding the role and actions of taurine.
Author: Anna Gvozdjáková
Author: Anna Gvozdjáková
Author: Anna Gvozdjáková
Author: Lawrence H. Lash
Author: Roberto Scatena
Author: Anna Gvozdjáková
Author: Roberto Scatena
Author: Saskia Koene
Author: 
Author: Manfred Lamprecht
Author: John B. Lombardini