QuaSAR, Quantitative Structure Activity Relationships of Analgesics, Narcotic Antagonists, and Hallucinogens PDF Download

Author:
Publisher:
ISBN:
Category : Analgesics
Languages : en
Pages : 508

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Author: Gene Barnett
Publisher:
ISBN:
Category : Analgesics
Languages : en
Pages : 508

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Author: Roy, Kunal
Publisher: IGI Global
ISBN: 1466681373
Category : Technology & Engineering
Languages : en
Pages : 727

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Book Description
Quantitative structure-activity relationships (QSARs) represent predictive models derived from the application of statistical tools correlating biological activity or other properties of chemicals with descriptors representative of molecular structure and/or property. Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis. Focusing on emerging research in the field, this book is an ideal reference source for industry professionals, students, and academicians in the fields of medicinal chemistry and toxicology.

Author: John Topliss
Publisher: Elsevier
ISBN: 0323146872
Category : Medical
Languages : en
Pages : 535

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Book Description
Medicinal Chemistry, Volume 19: Quantitative Structure-Activity Relationships of Drugs is a critical review of the applications of various quantitative structure-activity relationship (QSAR) methodologies in different drug therapeutic areas and discusses the results in terms of their contribution to medicinal chemistry. After briefly describing the developments in QSAR research, this 12-chapter volume goes on discussing the contributions of QSAR methodology in elucidating drug action and rational development of drugs against bacterial, fungal, viral, and other parasitic infections of man. Other chapters explore the mode of action and QSAR of antitumor, cardiovascular, antiallergic, antiulcer, antiarthritic, and nonsteroidal antiinflammatory drugs (NSAID) agents. The discussion then shifts to the pharmacologic effects and QSAR analysis of central nervous system agents, steroids, and other hormones. A chapter examines the major chemicals affecting insects and mites, with particular emphasis on the parameters of binding correlation and reactivity for insect and mite enzymes. The concluding chapters cover the limitations of the QSAR approach in the quantitative treatment of drug absorption, distribution, and metabolism. This volume is of great value to medicinal chemists, scientists, and researchers.

Author: Kyle C. Longest
Publisher: SAGE Publications
ISBN: 1483354059
Category : Social Science
Languages : en
Pages : 274

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Book Description
Using Stata for Quantitative Analysis, Second Edition offers a brief, but thorough introduction to analyzing data with Stata software. It can be used as a reference for any statistics or methods course across the social, behavioral, and health sciences since these fields share a relatively similar approach to quantitative analysis. In this book, author Kyle Longest teaches the language of Stata from an intuitive perspective, furthering students’ overall retention and allowing a student with no experience in statistical software to work with data in a very short amount of time. The self-teaching style of this book enables novice Stata users to complete a basic quantitative research project from start to finish. The Second Edition covers the use of Stata 13 and can be used on its own or as a supplement to a research methods or statistics textbook.

Author: David Alan Warren
Publisher:
ISBN:
Category :
Languages : en
Pages : 264

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Book Description
Time-courses of blood and brain concentrations and neurobehavioral toxicity were determined for two halocarbon solvents in two rodent species. Based on these data, quantitative relationships, or the lack thereof, have been reported between the degree of neurobehavioral toxicity and internal measures of dose. In the case of orally- administered perchloroethylene (PCE), relationships between blood and brain concentrations and operant performance were not discernable, due in part to an acute adaptation of rats to PCE's response suppressing effect. For inhaled 1,1,1- trichloroethane (TRI), blood and brain concentrations were strongly correlated with the rate of operant responding in rats.

Author:
Publisher: CUP Archive
ISBN:
Category :
Languages : en
Pages : 240

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Author: Roman Kaliszan
Publisher: Wiley-Interscience
ISBN:
Category : Science
Languages : en
Pages : 328

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Book Description
The use of computers in numerical characterization of molecular structures has given chemists fundamentally new information on chemical structures, leading to major developments in physical, analytical, and medicinal chemistry. This book, written by a pioneer in the field, extends and updates research on quantitative structure retention relationships (QSRR) by consolidating and critically reviewing the extensive literature on the subject while providing basic theoretical and practical information required in all investigations involving chromatography, analytical chemistry, biochemistry, and pharmaceutical research. Coverage includes detailed discussions of the general theories and mechanisms of chromatographic separations, prediction of retention coefficients, statistical techniques and formal requirements of QSRR studies, specific applications of chromatographic data, and much more. Also provides several carefully selected figures and tables plus extensive bibliographies.

Author: Fatma Kandemirli
Publisher: BoD – Books on Demand
ISBN: 9535134094
Category : Science
Languages : en
Pages : 90

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Book Description
The book, which is related to QSAR in sciences, is divided into five main chapters. The first chapter is the Introductory chapter. The second chapter aims to provide an update of the recent advances in the field of rational design of PDE inhibitors. The third chapter includes designing a series of peptidic inhibitors that possessed a substrate transition-state analog and evaluating the structure-activity relationship of the designed inhibitors, based on docking and scoring, using the docking simulation software Molecular Operating Environment. The aim of the forth chapter is to develop structure-property relationships for the qualitative and quantitative prediction of the reverse-phase liquid chromatographic retention times of chlorogenic acids. The final chapter aims to determine the model of interactions between the natural compounds with anti-inflammatory molecular target by molecular docking analysis.

Author: Haibo Zou
Publisher: Imperial College Press
ISBN: 1860948200
Category : Science
Languages : en
Pages : 305

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Book Description
Modern geochemistry possesses not only the vigor of geology and chemistry but also the rigor of mathematics. This book presents quantitative treatments of a wide range of fundamental problems related to geochemistry and geology. It shows that trace elements, isotopes, and equations are integrative tools in modern geochemistry for studying various Earth processes. In many chapters, simple models are presented first, and more parameters are gradually added so that the sophisticated models can be perceived as natural outgrowths of simple ones. The book will help scientists and graduate students in Earth Sciences improve their capacity to understand, apply, criticize, and appreciate the available models and possibly to develop their own models. This understanding will provide penetrating insights into fundamental principles in geochemistry, geology, analytical chemistry, and mass spectrometry as well as any other fields in the natural sciences.