Pyrrolizidine Alkaloids Health and Safety Guide PDF Download

Author: International Program on Chemical Safety
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 24

View

Book Description
This is a companion volume to Environmental Health Criteria 80: Pyrrolizidine alkaloids. Published by WHO for the International Programme on Chemical Safety, (a collaborative programme of UNEP, ILO and WHO)

Author: Helmut Wiedenfeld
Publisher: Vandenhoeck & Ruprecht
ISBN: 3899714261
Category : Pyrrolizidines
Languages : de
Pages : 145

View

Book Description
Pyrrolizidine alkaloids show only minor toxicity in their native state, but are metabolized in the human or animal organisms to carcinogenic, teratogenic and mutagenic compounds, with the precise structure of these compounds being responsible for the metabolic toxification process. Therefore, to be able to evaluate the toxic potential of each alkaloid, it is essential to exactly know the structure of the respective compound. X-ray structure analysis is the appropriate method both for elucidating the structure and for determining other parameters, such as the lengths of the bonds that influence the metabolic process. This book describes the incidence and the process of the intoxication as well as the possibilities to how the substances may reach the organism. In addition, the compounds elucidated by X-ray structure analysis to date are shown in their three-dimensional structure and structure-toxicity relationships are discussed.Pyrrolizidinalkaloide weisen in nativem Zustand nur geringe Toxizität auf, werden jedoch zu kanzerogenen, teratogenen und mutagenen Verbindungen metabolisiert, wenn sie in den menschlichen oder tierischen Organismus gelangen. Der Verlauf dieser Toxifizierung hängt von der konkreten Struktur dieser Stoffe und weiteren Parametern ab. Zur Bestimmung dieser Faktoren stellt die Röntgenstrukturanalyse die geeignete Methode dar. Im vorliegenden Buch werden das Vorkommen, der Ablauf der Toxifizierung und die Möglichkeiten, wie die Stoffe in den Organismus gelangen können, beschrieben. Es werden die bislang durch Röntgenstrukturanalyse vermessenen Verbindungen in ihrer 3D-Struktur aufgefÃ"hrt und Struktur-Toxizitätsbeziehungen diskutiert.

Author:
Publisher: World Health Organization
ISBN: 9240012672
Category : Medical
Languages : en
Pages : 414

View

Book Description

Author: A. R. Mattocks
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 424

View

Book Description

Author: Michael McGuffin
Publisher: CRC Press
ISBN: 9780849316753
Category : Science
Languages : en
Pages : 264

View

Book Description
The consumption of herbal products continues to increase, with an estimated sales growth of 10-15% per year projected through the end of the 1990s. As more and more consumers use herbs, it becomes that much more important to ensure that the herbs are used properly and safely. While herbs generally have a safe consumption history, information relevant to specific herbs and particular populations has not been easily available. The Botanical Safety Handbook provides readily accessible safety data in an easy-to-use classification system for more than 600 commonly sold herbs. The handbook also features additional information regarding international regulatory status, standard dosage, and certain common toxicity concerns. The editors of this book are among the most respected leaders in the herbal products industry. Their experience includes years of clinical practice, manufacturing and industry governance, and significant writing and lecturing about herbs. The Botanical Safety Handbook is for manufacturers of herbal products, health professionals who prescribe herbal remedies, and the consumer. This is a valuable resource for the safe dispensation of herbal products, and will help ensure the safe consumption of herbs through the 1990s and beyond.

Author: Rosemary Gladstar
Publisher: Simon and Schuster
ISBN: 1501175556
Category : Health & Fitness
Languages : en
Pages : 310

View

Book Description
Simple, safe, and effective herbal home remedies for women of all ages! From menstruation to menopause, learn how to prepare natural treatments for acne, PMS, morning sickness, hot flashes, yeast infections, and more. For centuries women have turned to herbs to cope with a wide variety of health problems and conditions. Comprehensive and easy-to-use, Herbal Healing for Women explains how to create remedies—including teas, tinctures, salves, and ointments—for the common disorders that arise in the different cycles of a woman's life. Covering adolescence, childbearing years, pregnancy and childbirth, and menopause, Rosemary Gladstar teaches how herbs can be used to treat the symptoms of conditions such as acne, PMS, morning sickness, and hot flashes. A complete women's health-care manual, Herbal Healing for Women discusses: -common disorders and the herbs that are effective for treating them -how to select and store herbs -preparation of hundreds of herbal remedies -an alphabetical listing of herbs, including a brief description of the herb, the general medicinal usage, and when necessary, warnings about potential side effects. By explaining the properties of specific herbs and the art of preparation, Rosemary Gladstar demonstrates not only how to achieve healing through herbs but good health as well.

Author:
Publisher:
ISBN:
Category : Chemicals
Languages : en
Pages : 44

View

Book Description

Author: World Health Organization
Publisher: Food & Agriculture Org. [Author] [Author]
ISBN: 9251335222
Category : Science
Languages : en
Pages : 414

View

Book Description
This volume contains monographs prepared at the eightieth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met in Rome, Italy, from 16 to 25 June 2015. [Author] The toxicological and dietary exposure monograph in this volume summarizes the safety and dietary exposure data on a contaminant group (pyrrolizidine alkaloids) discussed at the eightieth meeting. [Author] Monographs on seven food additives discussed at that meeting have been previously published in the WHO Food Additives series (FAS 71), and a monograph on a second contaminant group (non-dioxin-like polychlorinated biphenyls) has been published as a separate supplement in the WHO Food Additives series. [Author] This volume and others in the WHO Food Additives series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities. [Author]

Author: Mark Walderhaug
Publisher: Createspace Independent Publishing Platform
ISBN: 9781495203619
Category : Medical
Languages : en
Pages : 292

View

Book Description
The Bad Bug Book 2nd Edition, released in 2012, provides current information about the major known agents that cause foodborne illness.Each chapter in this book is about a pathogen—a bacterium, virus, or parasite—or a natural toxin that can contaminate food and cause illness. The book contains scientific and technical information about the major pathogens that cause these kinds of illnesses.A separate “consumer box” in each chapter provides non-technical information, in everyday language. The boxes describe plainly what can make you sick and, more important, how to prevent it.The information provided in this handbook is abbreviated and general in nature, and is intended for practical use. It is not intended to be a comprehensive scientific or clinical reference.The Bad Bug Book is published by the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA), U.S. Department of Health and Human Services.

Author: Sarah E. Edwards
Publisher: John Wiley & Sons
ISBN: 1118543564
Category : Science
Languages : en
Pages : 438

View

Book Description
Healthcare professionals, including doctors, pharmacists and nurses, are often confronted with patients who use over-the-counter (OTC) herbal medicinal products and food supplements. While taking responsibility for one’s own health and treatment options is encouraged, many patients use these products based on limited (and sometimes inaccurate) information from non-scientific sources, such as the popular press and internet. There is a clear need to offer balanced, well-informed advice to patients, yet a number of studies have shown that, generally, conventionally trained health practitioners consider their knowledge about herbal medicinal products and supplements to be weak. Phytopharmacy fills this knowledge gap, and is intended for use by the busy pharmacist, nurse, or doctor, as well as the ‘expert patient’ and students of pharmacy and herbal medicine. It presents clear, practical and concise monographs on over a hundred popular herbal medicines and plant-based food supplements. Information provided in each monograph includes: • Indications • Summary and appraisal of clinical and pre-clinical evidence • Potential interactions • Contraindications • Possible adverse effects An overview of the current regulatory framework is also outlined, notably the EU Traditional Herbal Medicinal Products Directive. This stipulates that only licensed products or registered traditional herbal medicinal products (THRs), which have assured quality and safety, can now legally be sold OTC. Monographs are included of most of the major herbal ingredients found in THRs, and also some plant-based food supplements, which while not strictly medicines, may also have the potential to exert a physiological effect.