Proton Pump Inhibitors: A Balanced View PDF Download

Author: T. Chiba
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318024163
Category : Medical
Languages : en
Pages : 130

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Book Description
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.

Author: T. Chiba
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318024155
Category : Medical
Languages : en
Pages : 130

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Book Description
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.

Author: Lars Olbe
Publisher: Birkhäuser
ISBN: 3034887957
Category : Medical
Languages : en
Pages : 245

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Book Description
Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be tween efficacy and safety of a new drug. This goal often involves time and many different specialists.

Author: Joel E. Richter
Publisher: John Wiley & Sons
ISBN: 1119599601
Category : Medical
Languages : en
Pages : 73

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Book Description
THE ESOPHAGUS The Esophagus investigates the anatomy, physiology, and pathology of the esophagus. This sixth edition, revised and updated throughout, also explores the diagnosis and treatment of various esophageal conditions. It includes treatment guidelines approved by the two largest gastroenterology societies, the ACG and AGA, as befits a work co-edited by two former presidents of those organizations. Advancements in diagnostics are presented, as are developments in the surgical and drug therapies. Presented in full colour, and boasting an unrivalled team of editors and contributing authors, The Esophagus Sixth Edition will find a home wherever the anatomy, physiology, and pathology of the esophagus are studied and taught. This book is accompanied by a website containing all the figures from the book in PowerPoint format. www.wiley.com/go/richter/esophagus6e Praise for the Fifth Edition: “There is absolutely no doubt that this edition of the textbook will maintain its status as the go-to reference for esophageal conditions, and will remain a highly utilized and clinically useful resource for novice and experienced physicians and surgeons alike.” (Gastroenterology, 1 July 2013)

Author: Irvin M. Modlin
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781741231
Category : Medical
Languages : en
Pages : 556

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Book Description
This textbook explores the history, biology, and treatment of acid related diseases, including gastric and duodenal ulcer disease, gastroesophageal reflux disease (GERD), and the role of H. pylori. The text offers thorough coverage of the subject matter, with an in-depth historical and biological focus. Equal focus is given to the biology and pharmacology of acid secretion and to the specific disease states of ulcers and GERD. This edition is full of new full-color medical illustrations of all aspects of this topic.

Author: Tracey Straker
Publisher:
ISBN: 0190850698
Category : Medical
Languages : en
Pages : 481

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Book Description
Using illustrative clinical cases, this volume in the Problem-Based Learning series reviews key topics in Anesthesia frequently encountered in clinical practice and on examinations. It highlights practical issues that arise in the operating room and solutions for them. With real-world clinical cases and discussion questions that guide case progression, this book facilitates both individual and small-group learning. Each case is further broken down to include additional related subtopics for maximum yield. Evidence-based reviews and multiple-choice self-assessment questions follow each case, making this book ideal for continuing education in anesthesia for the generalist and specialist practitioner. Teachers and trainees in anesthesiology will take advantage of this book's features for targeted teaching, learning, and retention.

Author: Michael F. Vaezi
Publisher: Springer
ISBN: 3319195247
Category : Medical
Languages : en
Pages : 165

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Book Description
This volume presents the most recent developments in diagnosis and treatment of patients with gastroesophageal reflux disease (GERD) and those who continue to be refractory to conventional GERD therapies. The book delineates the role of newly developed endoscopic therapies in GERD and outlines the best candidates for surgical fundoplication. Topics as the risks associated with GERD, lifestyle modification in GERD and the role of H2RA and proton pump inhibitor therapy in treating reflux disease are also explored. Written by authorities in the field, Diagnosis and Treatment of Gastroesophageal Reflux Disease is a concise yet comprehensive resource that is useful for primary care providers, gastroenterologists, pulmonologists, surgeons and ENT specialists.

Author: Leslie Neal-Boylan
Publisher: John Wiley & Sons
ISBN: 1118277856
Category : Medical
Languages : en
Pages : 432

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Book Description
Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.

Author: Norman Robillard, Ph.D.
Publisher: Norm Robillard, Ph.D.
ISBN: 0976642530
Category : Medical
Languages : en
Pages : 217

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Book Description
TRUTH ABOUT TRIGGER FOODS - They Are Not What You Think They Are ADDRESSING CAUSE AND EFFECT - Heartburn, Acid Reflux and GERD Relief without Drugs In the Fast Tract Digestion Heartburn, Norm Robillard, Ph.D., Founder of the Digestive Health Institute, explains the TRUE CAUSE and provides the COMPLETE DIETARY SOLUTION for acid reflux and GERD based on solid scientific evidence. This ground-breaking new approach -WHAT YOU EAT AFFECTS BACTERIA IN YOUR GUT- supported by a clinical study was presented at the recent Digestive Disease Week meeting in May, 2013 to provide a different treatment option to gastroenterologists for acid reflux and GERD. What people are saying about the Fast Tract Digestion Heartburn: "I weaned myself off proton pump inhibitors, and have avoided surgery completely. My quality of life is soooo much better. My gastroenterologists and surgeons are speechless.... His diet works. Period. Don't give up on it. Stick it out, and you will see the results.... I have never written a review on Amazon before, and am not being paid to say this. I feel so strongly about this book, that I had to let the world know." --- Joey I had been on PPI medication for over 10 years and tried from time to time to get off of them. But the acid reflux that returned was excruciating. I found this book, followed its advice and was so pleasantly surprised how well it works. Haven't taken a PPI in a month. The book is easy to read and understand and the recipes are really good. The charts in the book also make it easy to keep track of what and how much you can eat. I'd recommend this book to anyone who has GERD, takes medication for it and wants to get off of PPI's. --- DJ In the recent blog articles by the New York Time Best Seller Co-author of Protein Power, Dr. Mike Eades mentions the effectiveness of the Fast Tract Diet for GERD: http://www.proteinpower.com/drmike/gerdacid-reflux/gerd-treat-low-high-carb-diet/ http://www.proteinpower.com/drmike/gerdacid-reflux/gerd-treatment-nutrition-vs-drugs-3/ "Finally, after many years no more heartburn; Also no more bloating. I can't believe it. Why can't the gastroenerologists leave the pills alone." --- Henry T Ulrich "Thanks to Fast Tract Digestion diet and the consultative help of Norm Robillard via the Digestive Health Institute, I am now off meds, taking just an occasional TUMS. I feel better than I have since being diagnosed with GERD nearly two years ago. I expect that I will always need to be careful about what I eat, but it is a graded system that enables me to try gradual adjustments." --- Sunbeam48 According to Alana Sugar, a certified nutritionist with close to 25 years in practice: Dr. Robillard, your work has done the greatest service of all time for those of us facing these sorts of gut issues. The diet you have outlined is nutritionally balanced and safe! I tell my clients about your book and your work; I want everybody to know!

Author: Carl P. Weiner
Publisher: Elsevier Health Sciences
ISBN: 0323508707
Category : Medical
Languages : en
Pages : 1300

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Book Description
Logically organized and easy to use, Drugs for Pregnant and Lactating Women, 3rd Edition, is your #1 resource for details on how virtually all of today’s drugs and herbal supplements interact with pregnancy and lactation. More than just a dosing manual, this unique title by Dr. Carl P. Weiner fully explains whether each drug is FDA-approved for use by expecting or nursing mothers, is known to be safe for use, or is known to pose a danger. With up-to-date coverage of nearly 2,000 substances, it provides the thorough details you need to choose the most effective course of treatment. Uses a consistent, easy-to-follow format for each substance: generic and trade name • class • indications • mechanism of action • dosage, with contraindications and cautions • maternal considerations • fetal considerations • drug interactions • breastfeeding safety • references • and summary information. Describes over-the-counter drugs and alternative medications as well as prescription drugs. Uses an eye-catching icon to highlight known teratogens. Includes international drug names to give this reference a global perspective. Features new letter thumb tabs for easier navigation. Includes dozens of new drugs and thorough updates throughout.