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Protein Refolding

Protein Refolding PDF Author: George Georgiou
Publisher:
ISBN:
Category : SCIENCE
Languages : en
Pages : 248

Book Description
the refolding process is often the critical bottleneck in the production of high-value proteins, and recently acquired insights have yet to be translated into technological advantages. These proceedings bridge the gap between fundamental and applied studies, addressing such issues as in vivo protein folding, protein aggregation and inclusion body formation, elucidation of the folding pathway, characterization of folding intermediates, and practical considerations in protein renaturation. The symposium was part of the 199th ACS National Meeting, Boston, April 1990. Annotation copyrighted by Book News, Inc., Portland, OR

Protein Refolding

Protein Refolding PDF Author: George Georgiou
Publisher:
ISBN:
Category : SCIENCE
Languages : en
Pages : 248

Book Description
the refolding process is often the critical bottleneck in the production of high-value proteins, and recently acquired insights have yet to be translated into technological advantages. These proceedings bridge the gap between fundamental and applied studies, addressing such issues as in vivo protein folding, protein aggregation and inclusion body formation, elucidation of the folding pathway, characterization of folding intermediates, and practical considerations in protein renaturation. The symposium was part of the 199th ACS National Meeting, Boston, April 1990. Annotation copyrighted by Book News, Inc., Portland, OR

Guide to Protein Purification

Guide to Protein Purification PDF Author: Richard R Burgess
Publisher: Academic Press
ISBN: 0080923178
Category : Science
Languages : en
Pages : 915

Book Description
Guide to Protein Purification, Second Edition provides a complete update to existing methods in the field, reflecting the enormous advances made in the last two decades. In particular, proteomics, mass spectrometry, and DNA technology have revolutionized the field since the first edition's publication but through all of the advancements, the purification of proteins is still an indispensable first step in understanding their function. This volume examines the most reliable, robust methods for researchers in biochemistry, molecular and cell biology, genetics, pharmacology and biotechnology and sets a standard for best practices in the field. It relates how these traditional and new cutting-edge methods connect to the explosive advancements in the field. This "Guide to" gives imminently practical advice to avoid costly mistakes in choosing a method and brings in perspective from the premier researchers while presents a comprehensive overview of the field today. - Gathers top global authors from industry, medicine, and research fields across a wide variety of disciplines, including biochemistry, genetics, oncology, pharmacology, dermatology and immunology - Assembles chapters on both common and less common relevant techniques - Provides robust methods as well as an analysis of the advancements in the field that, for an individual investigator, can be a demanding and time-consuming process

Protein Refolding Using Molecular Assistants

Protein Refolding Using Molecular Assistants PDF Author: Peter Eric Hanson
Publisher:
ISBN:
Category :
Languages : en
Pages : 526

Book Description


Bioseparations of Proteins

Bioseparations of Proteins PDF Author: Ajit Sadana
Publisher: Elsevier
ISBN: 0080528147
Category : Science
Languages : en
Pages : 367

Book Description
This book covers the fundamentals of protein inactivation during bioseparation and the effect on protein processing. Bioseparation of Proteins is unique because it provides a background of the bioseparation processes, and it is the first book available to emphasize the influence of the different bioseparation processes on protein inactivation.Bioseparation of Proteins covers the extent, mechanisms of, and control of protein inactivation during these processes along with the subsequent and essential validation of these processes. The book focuses on the avoidance of protein (biologicalproduct) inactivation at each step in a bioprocess. It compares protein inactivation exhibited during the different bioseparation processes by different workers and provides a valuable framework for workers in different areas interested in bioseparations.Topics include separation and detection methods; estimates of protein inactivation and an analysis of this problem for different separation processes; strategies for avoiding inactivation; the molecular basis of surface activity and protein adsorption,process monitoring, and product validation techniques; and the economics of various bioseparation processes and quality control procedures.Key Features* Protein inactivation and other aspects of biological stability are critical to an effective bioseparation process; This book is a detailed and critical review of the available literature in an area that is essential to the effectiveness, validation, and economics of bioseparation processes for drugs and other biological products; Conveniently assembled under one cover, the survey of the literature and resulting perspective will greatly assist engineers and chemists in designingand improving their own processes; Key features of the text include:* detailed data on biological stability under various bioseparation conditions* extensive case studies from the literature on separation processes, validation, and economics* simplified analysis of protein refolding and inactivation mechanisms* consideration of adsorption theories and the effect of heterogeneity* coverage of both classical and novel bioseparation techniques, including chromatographic procedures

Detergent-mediated Protein Refolding

Detergent-mediated Protein Refolding PDF Author: Colin P. Crowley
Publisher:
ISBN:
Category :
Languages : en
Pages : 244

Book Description


Oxidative Folding of Proteins

Oxidative Folding of Proteins PDF Author: Matthias J Feige
Publisher: Royal Society of Chemistry
ISBN: 1788014855
Category : Science
Languages : en
Pages : 450

Book Description
The formation of disulphide bonds is probably the most influential modification of proteins. These bonds are unique among post-translational modifications of proteins as they can covalently link cysteine residues far apart in the primary sequence of a protein. This has the potential to convey stability to otherwise marginally stable structures of proteins. However, the reactivity of cysteines comes at a price: the potential to form incorrect disulphide bonds, interfere with folding, or even cause aggregation. An elaborate set of cellular machinery exists to catalyze and guide this process: facilitating bond formation, inhibiting unwanted pairings and scrutinizing the outcomes. Only in recent years has it become clear how intimately connected this cellular machinery is with protein folding helpers, organellar redox balance and cellular homeostasis as a whole. This book comprehensively covers the basic principles of disulphide bond formation in proteins and describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins. The biotechnological and pharmaceutical relevance of proteins, their variants and synthetic replicates is continuously increasing. Consequently this book is an invaluable resource for protein chemists involved in realted research and production.

Guide to Protein Purification

Guide to Protein Purification PDF Author: Murray P. Deutscher
Publisher: Gulf Professional Publishing
ISBN: 9780121820831
Category : Proteins
Languages : en
Pages : 936

Book Description
Guide to Protein Purification , designed to serve the needs of the student, experienced researcher and newcomer to the field, is a comprehensive manual that provides all the up-to-date procedures necessary for purifying, characterizing, and handling proteins and enzymes in one source. Key Features* Detailed procedures newly written for this volume* Extensive practical information* Rationale and strategies for protein and enzyme purification* Personal perspectives on enzyme purification by eminent researchersAmong the Topics Covered* General methods for handling proteins and enzymes * Extraction, subcellular fractionation, and solubilization procedures * Comprehensive purification techniques * Specialized purification procedures * Protein characterization * Immunological procedures * Computer analysis of protein structure.

Microfluidic Lab-on-a-chip Devices for Protein Refolding and Combinatorial Chemistry

Microfluidic Lab-on-a-chip Devices for Protein Refolding and Combinatorial Chemistry PDF Author: Prashant Sundar
Publisher:
ISBN:
Category :
Languages : en
Pages : 158

Book Description


Protein Folding, Misfolding, and Disease

Protein Folding, Misfolding, and Disease PDF Author: Andrew F Hill
Publisher: Springer
ISBN: 9781617791680
Category :
Languages : en
Pages : 260

Book Description


Aqueous Biphasic Separations

Aqueous Biphasic Separations PDF Author: Robin D. Rogers
Publisher: Springer Science & Business Media
ISBN: 1461519535
Category : Science
Languages : en
Pages : 191

Book Description
Proceedings of an American Chemical Society Symposium held in San Diego, California, March 13-14, 1994