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Author: Roby Paul Bhattacharyya Publisher: ISBN: Category : Languages : en Pages : 530
Book Description
One key source of specificity is the assembly of appropriate catalytic signaling elements into pathway-dedicated signaling complexes, often in response to a specific stimulus. Such complexes ensure that, once activated, each signaling component is most likely to encounter, and therefore signal to, its appropriate downstream partner. In this manner, the problem of specific information transfer is reduced to the biochemically simpler problem of specific protein recognition required to assemble these signaling complexes.
Author: Roby Paul Bhattacharyya Publisher: ISBN: Category : Languages : en Pages : 530
Book Description
One key source of specificity is the assembly of appropriate catalytic signaling elements into pathway-dedicated signaling complexes, often in response to a specific stimulus. Such complexes ensure that, once activated, each signaling component is most likely to encounter, and therefore signal to, its appropriate downstream partner. In this manner, the problem of specific information transfer is reduced to the biochemically simpler problem of specific protein recognition required to assemble these signaling complexes.
Author: Francesc Posas Publisher: Springer Science & Business Media ISBN: 3540755691 Category : Science Languages : en Pages : 322
Book Description
In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.
Author: Marc R. Wilkins Publisher: Springer Science & Business Media ISBN: 366203493X Category : Science Languages : en Pages : 256
Book Description
Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.
Author: Jean-Paul Latgé Publisher: ISBN: Category : Science Languages : en Pages : 612
Book Description
Offers the latest insights into the fundamental biology and pathogenesis of A. fumigatus. Provides a combined synopsis of both A. fumigatus and its diseases and therapies. Encompasses the most up-to-date knowledge to serve as a resource guide for the next decade of study on this organism and the many diseases it causes. Covers the fundamental biology of A. fumigatus including specific features in genetics, biochemistry, and cell biology that can explain the virulence of this opportunistic pathogen. Discusses the wide range of clinical infection, plus the latest diagnostic and treatment strategies, in specific patient populations.
Author: Vincent Goffin Publisher: Springer Science & Business Media ISBN: 9780792376606 Category : Medical Languages : en Pages : 340
Book Description
Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Author: Monika Fuxreiter Publisher: Springer Science & Business Media ISBN: 1461406595 Category : Medical Languages : en Pages : 210
Book Description
Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
Author: Paul Shapiro Publisher: Springer Nature ISBN: 3030482839 Category : Medical Languages : en Pages : 224
Book Description
Protein kinases are fascinating enzymes that maintain the proper function of nearly every task performed by the cells of the human body. By extracting a phosphate from the energy molecule ATP and linking it to another protein, protein kinases alter the structure and ultimate function of other proteins. In this way, protein kinases help monitor the extracellular environment and integrate signaling cues that, for the most part, are beneficial for human health and survival. However, protein kinases are often dysregulated and responsible for the initiation and progression of many types of cancers, inflammatory disorders, and other diseases. Thus, decades of research have revealed much about how protein kinases are regulated and approaches to inhibit these enzymes to treat disease. However, nearly 30 years since the identification of the first clinically beneficial small molecule protein kinase inhibitor, there are only a few examples where these drugs provide sustained and durable patient responses. The goal of this book is to provide biomedical scientists, graduate, and professional degree students insight into different approaches using small molecules to block specific protein kinase functions that promote disease.
Author: Ayse Basak Engin Publisher: Springer Nature ISBN: 3030498441 Category : Medical Languages : en Pages : 415
Book Description
Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author: Roby Paul Bhattacharyya
Author: Roby Paul Bhattacharyya
Author: Francesc Posas
Author: Gregory J. Della Rocca
Author: Marc R. Wilkins
Author: Jean-Paul Latgé
Author: Bruce Alberts
Author: Vincent Goffin
Author: Monika Fuxreiter
Author: Paul Shapiro
Author: Ayse Basak Engin