Prostaglandins in the Cardiovascular System PDF Download

Author: Helmut Sinzinger
Publisher: Birkhauser
ISBN:
Category : Cardiovascular system
Languages : en
Pages : 402

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Author: Karsten Schrör
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Medical
Languages : en
Pages : 596

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Author: John A. Oates
Publisher:
ISBN: 9780890045800
Category : Appareil cardiovasculaire
Languages : en
Pages : 388

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Author: Ryszard Gryglewski
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 344

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Ten years after the discovery of prostacyclin, our knowledge of its biochemical mode of action, pharmacological properties, pathophysiological significance and therapeutic applications is ever expanding. Prostacyclin is both complex and unique as demonstrated by its unusual feature of being chemically and meta bolically unstable when compared to other prostanoids and known amine or peptide mediators. Although physiologically essential, the chemical instability of prostacyclin poses a serious drawback in laboratory and clinical studies. It is one of the genuine objectives of pharmaceutical research to supply synthetic compounds which overcome the inherent drawbacks - considering investigational and therapeutic use - of endogenous compounds. Whereas metabolic instability in certain cases could be of advantage, chemical instability definitely is not. With Iloprost, a molecule has been designed which - according to all data so far available - pertains high receptor affinity, metabolic instability (clinically this equates with a fine control of Iloprost's effects) while chemical stability has been achieved. By virtue of these characteristics Iloprost can be considered as one step towards specific interaction within the arachidonic acid cascade, namely the prostacyclin receptor. The aim of the symposium was to provide a critical experimental appraisal concerning the biochemical mode of action and pharmacological properties of prostacyclin and Iloprost.

Author: K. Schrör
Publisher:
ISBN:
Category :
Languages : en
Pages : 572

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Author: Karsten Schörr
Publisher: Alan R. Liss
ISBN:
Category : Medical
Languages : en
Pages : 680

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Book Description

Author: Takayuki Ozawa
Publisher: Taylor & Francis Group
ISBN:
Category : Medical
Languages : en
Pages : 236

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Author: A. Scriabine
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 530

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Author: L. David Hillis
Publisher:
ISBN:
Category :
Languages : en
Pages : 48

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Author: Jawahar Mehta
Publisher: Wiley-Blackwell
ISBN:
Category : Medical
Languages : en
Pages : 466

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