Process Analytical Chemistry PDF Download

Author: F. McLennan
Publisher: Springer Science & Business Media
ISBN: 940110591X
Category : Science
Languages : en
Pages : 391

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Book Description
Process analytical chemistry (PAC) can be defined as the technology of obtaining quantitative and qualitative information about a chemical process in order to control or optimise its performance. This highly practical book provides an up-to-date introduction to the field with a special emphasis placed on industrial processes. Edited by representatives from one of the world's leading chemical companies and centres of excellence for research into the subject, the book is written by a transatlantic team of authors who provide a global perspective.

Author: Katherine A. Bakeev
Publisher: John Wiley & Sons
ISBN: 0470689609
Category : Science
Languages : en
Pages : 576

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Book Description
Process Analytical Technology explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the analytical chemist. In this new edition all of the original chapters have been updated and revised, and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added. Coverage includes: Implementation of Process Analytical Technologies UV-Visible Spectroscopy for On-line Analysis Infrared Spectroscopy for Process Analytical Applications Process Raman Spectroscopy Process NMR Spectrscopy: Technology and On-line Applications Fluorescent Sensing and Process Analytical Applications Chemometrics in Process Analytical Technology (PAT) On-Line PAT Applications of Spectroscopy in the Pharmaceutical Industry Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing NIR Chemical Imaging This volume is an important starting point for anyone wanting to implement PAT and is intended not only to assist a newcomer to the field but also to provide up-to-date information for those who practice process analytical chemistry and PAT. It is relevant for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focussing on PAT. Review from the First Edition “The book provides an excellent first port of call for anyone seeking material and discussions to understand the area better. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology.”—Current Engineering Practice

Author: Karl H. Koch
Publisher: Springer Science & Business Media
ISBN: 3662037726
Category : Science
Languages : en
Pages : 251

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Book Description
This practice-oriented book introduces chemists, engineers and technicians to the strategies, techniques and efficiency of modern process analytical chemistry. The author targets in particular those professionals in SMEs who have to carry out process control tasks in a "solo-run".

Author: Colm P. O'Donnell
Publisher: Springer
ISBN: 149390311X
Category : Technology & Engineering
Languages : en
Pages : 301

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Book Description
The Process Analytical Technology (PAT) initiative aims to move from a paradigm of ‘testing quality in’ to ‘building quality in by design’. It can be defined as the optimal application of process analytical technologies, feedback process control strategies, information management tools, and/or product–process optimization strategies. Recently, there have been significant advances in process sensors and in model-based monitoring and control methodologies, leading to enormous opportunities for improved performance of food manufacturing processes and for the quality of food products with the adoption of PAT. Improvements in process efficiency, reduced product variability, enhanced traceability, process understanding, and decreased risk of contamination are some of the benefits arising from the introduction of a PAT strategy in the food industry. Process Analytical Technology for the Food Industry reviews established and emerging PAT tools with potential application within the food processing industry. The book will also serve as a reference for industry, researchers, educators, and students by providing a comprehensive insight into the objectives, challenges, and benefits of adopting a Process Analytical Technology strategy in the food industry.

Author: John M. Chalmers
Publisher: Wiley-Blackwell
ISBN: 9781841270401
Category : Science
Languages : en
Pages : 380

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Book Description
This volume concentrates on the attributes, requirements and applications of spectroscopic techniques in process analysis, considering off-line and at-/near-line methodology, in addition to on-line, in-line and non-invasive approaches. At a time when cost- and time-effective process spectroscopy is becoming an issue of increasing importance within the chemical industry, this volume provides a valuable source of up-to-date information on technological advances in the area. It complements more general works on process analytical chemistry.

Author: Gennady E. Zaikov
Publisher: CRC Press
ISBN: 0429845464
Category : Science
Languages : en
Pages : 278

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Book Description
This book highlights many of the latest developments and trends in engineering chemistry research and describes the respective tools to characterize and predict properties and behavior of materials. The book provides original, theoretical, and important experimental results which use non-routine methodologies and presents chapters on novel applications of more familiar experimental techniques and analyses of composite problems which indicate the need for new experimental approaches presented. Technical and technological development demands the creation of new materials that are stronger, more reliable and more durable, i.e. materials with new properties. This volume presents new research that will help lead to new and better materials. Each chapter describes the principle of the respective method as well as the detailed procedures of experiments with examples of actual applications presented. Thus, readers will be able to apply the concepts as described in the book to their own experiments. Experts in each of the areas covered have reviewed the state of the art, thus creating a book that will be useful to readers at all levels in academic, industry, and research institutions. Engineers, polymer scientists, and technicians will find this volume useful in selecting approaches and techniques applicable to characterizing molecular, compositional, rheological, and thermodynamic properties of elastomers and plastics.

Author: Peter J. Harrington
Publisher: John Wiley & Sons
ISBN: 0470922869
Category : Science
Languages : en
Pages : 815

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Book Description
There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Author: Somenath Mitra
Publisher: John Wiley & Sons
ISBN: 0471457825
Category : Science
Languages : en
Pages : 480

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Book Description
The importance of accurate sample preparation techniques cannot be overstated--meticulous sample preparation is essential. Often overlooked, it is the midway point where the analytes from the sample matrix are transformed so they are suitable for analysis. Even the best analytical techniques cannot rectify problems generated by sloppy sample pretreatment. Devoted entirely to teaching and reinforcing these necessary pretreatment steps, Sample Preparation Techniques in Analytical Chemistry addresses diverse aspects of this important measurement step. These include: * State-of-the-art extraction techniques for organic and inorganic analytes * Sample preparation in biological measurements * Sample pretreatment in microscopy * Surface enhancement as a sample preparation tool in Raman and IR spectroscopy * Sample concentration and clean-up methods * Quality control steps Designed to serve as a text in an undergraduate or graduate level curriculum, Sample Preparation Techniques in Analytical Chemistry also provides an invaluable reference tool for analytical chemists in the chemical, biological, pharmaceutical, environmental, and materials sciences.

Author: Miguel Valcarcel
Publisher: Springer Science & Business Media
ISBN: 3642571573
Category : Science
Languages : en
Pages : 385

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Book Description
Principles of Analytical Chemistry gives readers a taste of what the field is all about. Using keywords of modern analytical chemistry, it constructs an overview of the discipline, accessible to readers pursuing different scientific and technical studies. In addition to the extremely easy-to-understand presentation, practical exercises, questions, and lessons expound a large number of examples.

Author: James M. Miller
Publisher: Wiley-Interscience
ISBN:
Category : Medical
Languages : en
Pages : 520

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Book Description
Based on the Laboratory Analyst Training and Certification Program ... chemists from a range of pharmaceutical companies and a few academic laboratories explain how to comply with the US Food and Drug Administration's Good Manufacturing Practice rules as analytical technologies are changing rapidly .... Among the topics are the drug development process, uniform and consistent interpretation of compliance issues, the role of statistics and basic topics in analytical chemistry, and detectors and quantitative analysis. The emphasis is on high-performance liquid chromatographic methods.