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Author: International Labour Organisation Publisher: World Health Organization ISBN: 9241572361 Category : Medical Languages : en Pages : 360
Book Description
This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description.
Author: International Labour Organisation Publisher: World Health Organization ISBN: 9241572361 Category : Medical Languages : en Pages : 360
Book Description
This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description.
Author: World Health Organization Publisher: ISBN: Category : Medical Languages : en Pages : 416
Book Description
A comprehensive guide to general strategies and specific methods for testing the immunotoxicity of chemicals in animal models and humans. Addressed to those seeking a basic introduction to the field as well as specialist researchers the book takes its focus from growing concern in scientific and public communities about the capacity of environmental agents to disrupt normal immune functions and thus increase susceptibility to tumours and infectious diseases. Compounds known to adversely affect the immune system are numerous and include drugs pesticides solvents halogenated and aromatic hydrocarbons and metals. The book draws on considerable recent progress in understanding the immunological consequences of chemical insults as well as increasingly sophisticated methodologies for assessing such effects. Close to 1000 references are included in this authoritative guide. The book opens with a detailed basic introduction to immunotoxicology. An extensive explanation of the function histophysiology and pathophysiology of the immune system emphasizes features that can aid the understanding and interpretation of the pathological changes caused by immunotoxic insults. Chapter two on the health impact of selected immunotoxic agents gives illustrative examples for some 30 chemicals that have been shown to exert immunotoxic effects in laboratory animals and for an additional seven groups of chemicals known to disturb immune functions in humans. For each brief discussions illustrate the chemical's distinct immunosuppressive properties and the mechanisms by which it exerts its toxic effects on the immune system. Chapter three provides detailed descriptions of a number of tests used in a tiered approach to the assessment of immunotoxicity. Against this background specific nonfunctional and functional tests for the assessment of immunotoxicology in experimental animals are presented and explained in full detail. Information on individual tests includes an explanation of why the test is important the types of data it can yield and exactly how it should be performed. Also included are sections offering advice on assessments in non-rodent species in vitro approaches and approaches using biomarkers in epidemiological studies and monitoring. The chapter concludes with a discussion of good laboratory practices for immunotoxicology studies and procedures for the validation of tests. Chapter five explains the much more complicated procedures needed to assess immunotoxicity in humans. An explanation of general questions to be considered when designing epidemiological studies is followed by presentation of three recommended testing schemes proposed by WHO and other agencies for preliminary evaluation of individuals exposed to immunotoxicants. Specific assays for assessing immune status are also described. The final chapter outlines a step-by-step process of risk assessment specific to the evaluation of potentially immunotoxic chemicals.
Author: James C. Bonner Publisher: Springer Nature ISBN: 3030339629 Category : Medical Languages : en Pages : 229
Book Description
This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.
Author: A. Wallace Hayes Publisher: CRC Press ISBN: 1842145371 Category : Medical Languages : en Pages : 2184
Book Description
Hayes' Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chap
Author: World Health Organization Publisher: World Health Organization ISBN: 9241572396 Category : Medical Languages : en Pages : 164
Book Description
"Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
Author: Helmut Greim Publisher: John Wiley & Sons ISBN: 1119135915 Category : Science Languages : en Pages : 838
Book Description
Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.
Author: Esteban Ballestar Publisher: Springer Science & Business Media ISBN: 1441982167 Category : Medical Languages : en Pages : 196
Book Description
This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.
Author: Andreas Luch Publisher: Springer Science & Business Media ISBN: 3764383402 Category : Medical Languages : en Pages : 580
Book Description
Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
Author: International Labour Organisation
Author: International Labour Organisation
Author: World Health Organization
Author: 
Author: James C. Bonner
Author: World Health Organization
Author: A. Wallace Hayes
Author: World Health Organization
Author: Helmut Greim
Author: Esteban Ballestar
Author: Andreas Luch