Handbook of Practical Immunohistochemistry PDF Download

Author: Fan Lin
Publisher: Springer
ISBN: 1493915789
Category : Medical
Languages : en
Pages : 756

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Book Description
In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

Author: Steven E. Schild, MD
Publisher: Demos Medical Publishing
ISBN: 1935281801
Category : Medical
Languages : en
Pages : 260

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Book Description
Thoracic Malignancies: Thoracic Malignancies is the first title in Radiation Medicine Rounds. These tumors take more lives than any others and they are among the most preventable of tumors. Thus it is crucial for the practitioner to be up-to-date on the latest insights regarding their management. Thoracic Malignancies addresses the multi-disciplinary nature of the care of these tumors. There is representation from radiation oncology, medical oncology, and surgery ensuring a well-rounded summarization of current practice. Included are chapters on lung cancer, esophageal cancer, and thymomas providing coverage of the vast majority of thoracic tumors. The multi-disciplinary nature of the articles provides readers with an up-to-date summary and a well-rounded review regarding these tumors and their care. Expert authors provide reviews and assessments of the most recent data and its implications for current clinical practice, along with insights into emerging new trends of importance for the near future. About the Series Radiation Medicine Rounds is an invited review publication providing a thorough analysis of new scientific, technologic, and clinical advances in all areas of radiation medicine. There is an emphasis throughout on multidisciplinary approaches to the specialty, as well as on quality and outcomes analysis. Published three times a year Radiation Medicine Rounds provides authoritative, thorough assessments of a wide range of Ïhot topicsÓ and emerging new data for the entire specialty of radiation medicine. Features of Radiation Medicine Rounds include: Editorial board of nationally recognized experts across the spectrum of radiation medicine In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Radiation Medicine Issues edited by an authority in specific subject area Focuses on major topics in Radiation Medicine with in-depth articles covering advances in radiation science radiation medicine technology, radiation medicine practice, and assessment of recent quality and outcomes studies Emphasizes multidisciplinary approaches to research and practice

Author: Steven Piantadosi
Publisher: Springer Nature
ISBN: 3319526367
Category : Medical
Languages : en
Pages : 2573

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Book Description
This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.

Author: Raymond C. Bergan
Publisher: Springer
ISBN: 9781461356639
Category : Medical
Languages : en
Pages : 0

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Book Description
This volume offers a broad overview of topics related to cancer chemoprevention. It provides a review of topics ranging from basic research arenas to clinical trial design, implementation, and interpretation. It covers all key areas necessary for understanding the field of cancer chemoprevention for the interested reader, for individuals wishing to enter this area of investigation, and for individuals seeking guidance in particular areas of research, relating to agent identification, basic science investigations and clinical trials. The genesis of this book is based on the fact that cancer chemoprevention is a relatively new and rapidly evolving field spanning a wide array of disciplines, and forces researchers to address difficult and complex questions whose answers are not readily available. Cancer Chemoprevention provides a ready resource whose importance and intent lie in its ability to gather and solidify disparate data to explicitly outline areas of difficulty and to highlight future areas of important development. It provides broad outlines for current, ongoing and future directions in this area with various target organ sites, written by experts in their respective fields, whose primary research focuses upon that individual field.

Author: Paul Meehl
Publisher: Echo Point Books & Media
ISBN: 9781626542303
Category : Medical
Languages : en
Pages : 164

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Book Description
"Clinical versus Statistical Prediction" is Paul Meehl's famous examination of benefits and disutilities related to the different ways of combining information to make predictions. It is a clarifying analysis as relevant today as when it first appeared. A major methodological problem for clinical psychology concerns the relation between clinical and actuarial methods of arriving at diagnoses and predicting behavior. Without prejudging the question as to whether these methods are fundamentally different, we can at least set forth the obvious distinctions between them in practical applications. The problem is to predict how a person is going to behave: What is the most accurate way to go about this task? "Clinical versus Statistical Prediction" offers a penetrating and thorough look at the pros and cons of human judgment versus actuarial integration of information as applied to the prediction problem. Widely considered the leading text on the subject, Paul Meehl's landmark analysis is reprinted here in its entirety, including his updated preface written forty-two years after the first publication of the book. This classic work is a must-have for students and practitioners interested in better understanding human behavior, for anyone wanting to make the most accurate decisions from all sorts of data, and for those interested in the ethics and intricacies of prediction. As Meehl puts it, " "When one is dealing with human lives and life opportunities, it is immoral to adopt a mode of decision-making which has been demonstrated repeatedly to be either inferior in success rate or, when equal, costlier to the client or the taxpayer.""

Author: Bernardo L. Rapoport
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318068187
Category : Medical
Languages : en
Pages : 109

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Book Description
Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy

Author: A.J. Lees
Publisher: New York Review of Books
ISBN: 1912559218
Category : Travel
Languages : en
Pages : 153

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Book Description
A famed British neurologist embarks on an expedition in Brazil to follow the trail of Percy Fawcett, an occult-obsessed explorer who went missing in the Amazon rainforest and was the subject of the 2016 film The Lost City of Z. As a boy growing up near Liverpool in the 1950s, Andrew Lees would visit the docks with his father to watch the ships from Brazil unload their exotic cargo of coffee, cotton bales, molasses, and cocoa. One day, his father gave him a dog-eared book called Exploration Fawcett. The book told the true story of Lieutenant Colonel Percy Fawcett, a British explorer who in 1925 had gone in search of a lost city in the Amazon and never returned. The riveting story of Fawcett's encounters with deadly animals and hostile tribes, his mission to discover an Atlantean civilization, and the many who lost their own lives when they went in search of him inspired the young Lees to believe that there were still earthly places where one could "fall off the edge." Years later, after becoming a successful neurologist, Lees set off in search of the mysterious figure of Fawcett. What he found exceeded his wildest imaginings. With access to the cache of "Secret Papers," Lees discovered that Fawcett's quest was far stranger than searching for a lost city. There was a "greater mission," one that involved the occult and a belief in a community of evolved beings living in a hidden parallel plane in the Mato Grosso. Lees traveled to Manaus in Fawcett's footsteps. After a time-bending psychedelic experience in the forest, he understood that his yearning for the imaginary Brazil of his boyhood, like Fawcett's search for an earthly paradise, was a nostalgia for what never was. Part travelogue, part memoir, Lees paints a portrait of an elusive Brazil, and of a flawed explorer whose doomed mission ruined lives.

Author: Ralph Keyes
Publisher: Oxford University Press
ISBN: 0190466774
Category : Language Arts & Disciplines
Languages : en
Pages : 320

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Book Description
Successful word-coinages--those that stay in currency for a good long time--tend to conceal their beginnings. We take them at face value and rarely when and where they were first minted. Engaging, illuminating, and authoritative, Ralph Keyes's The Hidden History of Coined Words explores the etymological underworld of terms and expressions and uncovers plenty of hidden gems. He also finds some fascinating patterns, such as that successful neologisms are as likely to be created by chance as by design. A remarkable number of new words were coined whimsically, originally intended to troll or taunt. Knickers, for example, resulted from a hoax; big bang from an insult. Casual wisecracking produced software, crowdsource, and blog. More than a few resulted from happy accidents, such as typos, mistranslations, and mishearing (bigly and buttonhole), or from being taken entirely out of context (robotics). Neologizers (a Thomas Jefferson coinage) include not just scholars and writers but cartoonists, columnists, children's book authors. Wimp originated with a book series, as did goop, and nerd from a book by Dr. Seuss. Coinages are often contested, controversy swirling around such terms as gonzo, mojo, and booty call. Keyes considers all contenders, while also leading us through the fray between new word partisans, and those who resist them strenuously. He concludes with advice about how to make your own successful coinage. The Hidden History of Coined Words will appeal not just to word mavens but history buffs, trivia contesters, and anyone who loves the immersive power of language.

Author:
Publisher:
ISBN:
Category : Trademarks
Languages : en
Pages : 536

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Book Description

Author: Alexander Green
Publisher: John Wiley & Sons
ISBN: 1119817854
Category : Business & Economics
Languages : en
Pages : 288

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Book Description
Learn how to invest, relax, and let your money do the work with this incredible guide Fully revised, updated, and expanded for the first time since its New York Times Best-Selling debut in 20TK, the legendary Alexander Green's essential guide for individual investors spells out stock-market success for everyone from first-timers to seasoned pros. The Gone Fishin' Portfolio: Get Wise, Get Wealthy...and Get on With Your Life, Second Edition delivers a long-term investment strategy that lets you reap the rewards of financial success with a simple, yet sophisticated, strategy that increases returns, reduces risk, and leaves you with time to enjoy the finer things in life. You'll learn about the fundamental relationship between risk and reward in the financial markets and get a trading insider's view of how the investment industry actually works. With The Gone Fishin' Portfolio, you'll also discover: How to take your financial future into your own hands How to invest in a way that doesn’t require you to spend every waking moment worrying about your money How to avoid the most common traps the investment industry sets for you Why skilled investing doesn't have to be complicated Perfect for individual investors who want to put their money to work for them, The Gone Fishin' Portfolio gives you all the tools you need to manage your own money and maximize your investment returns today.