The Target Organ and the Toxic Process PDF Download

Author: Philip L. Chambers
Publisher: Springer
ISBN: 9783540185123
Category : Medical
Languages : en
Pages : 0

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Author: Luke A. Nichter
Publisher: Yale University Press
ISBN: 0300217803
Category : Biography & Autobiography
Languages : en
Pages : 553

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The first biography of a man who was at the center of American foreign policy for a generation Few have ever enjoyed the degree of foreign-policy influence and versatility that Henry Cabot Lodge Jr. did—in the postwar era, perhaps only George Marshall, Henry Kissinger, and James Baker. Lodge, however, had the distinction of wielding that influence under presidents of both parties. For three decades, he was at the center of American foreign policy, serving as advisor to five presidents, from Dwight Eisenhower to Gerald Ford, and as ambassador to the United Nations, Vietnam, West Germany, and the Vatican. Lodge’s political influence was immense. He was the first person, in 1943, to see Eisenhower as a potential president; he entered Eisenhower in the 1952 New Hampshire primary without the candidate’s knowledge, crafted his political positions, and managed his campaign. As UN ambassador in the 1950s, Lodge was effectively a second secretary of state. In the 1960s, he was called twice, by John F. Kennedy and by Lyndon Johnson, to serve in the toughest position in the State Department’s portfolio, as ambassador to Vietnam. In the 1970s, he paved the way for permanent American ties with the Holy See. Over his career, beginning with his arrival in the U.S. Senate at age thirty-four in 1937, when there were just seventeen Republican senators, he did more than anyone else to transform the Republican Party from a regional, isolationist party into the nation’s dominant force in foreign policy, a position it held from Eisenhower’s time until the twenty-first century. In this book, historian Luke A. Nichter gives us a compelling narrative of Lodge’s extraordinary and consequential life. Lodge was among the last of the well‑heeled Eastern Establishment Republicans who put duty over partisanship and saw themselves as the hereditary captains of the American state. Unlike many who reach his position, Lodge took his secrets to the grave—including some that, revealed here for the first time, will force historians to rethink their understanding of America’s involvement in the Vietnam War.

Author: Patrick K. O'Donnell
Publisher: Grove Atlantic
ISBN: 0802156916
Category : History
Languages : en
Pages : 322

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The acclaimed combat historian and author of The Unknowns details the history of the Marbleheaders and their critical role in the Revolutionary War. On the stormy night of August 29, 1776, the Continental Army faced annihilation after losing the Battle of Brooklyn. The British had trapped George Washington’s army against the East River, and the fate of the Revolution rested upon the soldier-mariners from Marblehead, Massachusetts. One of the country’s first diverse units, they pulled off an “American Dunkirk” and saved the army by navigating the treacherous river to Manhattan. At the right time in the right place, the Marbleheaders, a group of white, black, Hispanic, and Native American soldiers, repeatedly altered the course of events, and their story shines new light on our understanding of the American Revolution. As historian Patrick K. O’Donnell recounts, beginning nearly a decade before the war started, Marbleheaders such as Elbridge Gerry and Azor Orne spearheaded the break with Britain and helped shape the United States through governing, building alliances, seizing British ships, forging critical supply lines, and establishing the origins of the US Navy. The Marblehead Regiment, led by John Glover, became truly indispensable. Marbleheaders battled at Lexington and on Bunker Hill and formed the elite Guard that protected George Washington, foreshadowing today’s Secret Service. Then the special operations–like regiment, against all odds, conveyed 2,400 of Washington’s men across the ice-filled Delaware River on Christmas night of 1776, delivering the surprise attack on Trenton that changed the course of history . . . The Marbleheaders’ story, never fully told before now, makes The Indispensables a vital addition to the literature of the American Revolution. Praise for The Indispensables “Perfectly paced and powerfully wrought, this is the story of common men who gave everything for an ideal—America. The product of meticulous research, The Indispensables is the perfect reminder of who we are, when we need it most.” —Adam Makos, author of the New York Times bestseller A Higher Call “O’Donnell’s gift for storytelling brings the once famous regiment back to life, as he takes readers from the highest war councils to the grime and grit of battle.” —Dr. James Lacey, author of The Washington War “Comprehensive . . . Revolutionary War buffs will delight in the copious details and vivid battle scenes.” —Publishers Weekly “A vivid account of an impressive Revolutionary War unit and a can’t-miss choice for fans of O’Donnell’s previous books.” —Kirkus Review

Author: Brandy Schillace
Publisher: Simon and Schuster
ISBN: 1982113820
Category : Biography & Autobiography
Languages : en
Pages : 320

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The “delightfully macabre” (The New York Times) true tale of a brilliant and eccentric surgeon…and his quest to transplant the human soul. In the early days of the Cold War, a spirit of desperate scientific rivalry birthed a different kind of space race: not the race to outer space that we all know, but a race to master the inner space of the human body. While surgeons on either side of the Iron Curtain competed to become the first to transplant organs like the kidney and heart, a young American neurosurgeon had an even more ambitious thought: Why not transplant the brain? Dr. Robert White was a friend to two popes and a founder of the Vatican’s Commission on Bioethics. He developed lifesaving neurosurgical techniques still used in hospitals today and was nominated for the Nobel Prize. But like Dr. Jekyll before him, Dr. White had another identity. In his lab, he was waging a battle against the limits of science and against mortality itself—working to perfect a surgery that would allow the soul to live on after the human body had died. This “fascinating” (The Wall Street Journal), “provocative” (The Washington Post) tale follows his decades-long quest into tangled matters of science, Cold War politics, and faith, revealing the complex (and often murky) ethics of experimentation and remarkable innovations that today save patients from certain death. It’s a “masterful” (Science) look at our greatest fears and our greatest hopes—and the long, strange journey from science fiction to science fact.

Author: Banafshé Larijani
Publisher: Humana Press
ISBN: 9781588297273
Category : Science
Languages : en
Pages : 0

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Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Author: Andrew Whitby
Publisher: Basic Books
ISBN: 1541619331
Category : History
Languages : en
Pages : 317

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This fascinating three-thousand-year history of the census traces the making of the modern survey and explores its political power in the age of big data and surveillance. In April 2020, the United States will embark on what has been called "the largest peacetime mobilization in American history": the decennial population census. It is part of a tradition of counting people that goes back at least three millennia and now spans the globe. In The Sum of the People, data scientist Andrew Whitby traces the remarkable history of the census, from ancient China and the Roman Empire, through revolutionary America and Nazi-occupied Europe, to the steps of the Supreme Court. Marvels of democracy, instruments of exclusion, and, at worst, tools of tyranny and genocide, censuses have always profoundly shaped the societies we've built. Today, as we struggle to resist the creep of mass surveillance, the traditional census -- direct and transparent -- may offer the seeds of an alternative.

Author: Danielle Dreilinger
Publisher: W. W. Norton & Company
ISBN: 1324004509
Category : History
Languages : en
Pages : 326

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The surprising, often fiercely feminist, always fascinating, yet barely known, history of home economics. The term “home economics” may conjure traumatic memories of lopsided hand-sewn pillows or sunken muffins. But common conception obscures the story of the revolutionary science of better living. The field exploded opportunities for women in the twentieth century by reducing domestic work and providing jobs as professors, engineers, chemists, and businesspeople. And it has something to teach us today. In the surprising, often fiercely feminist and always fascinating The Secret History of Home Economics, Danielle Dreilinger traces the field’s history from Black colleges to Eleanor Roosevelt to Okinawa, from a Betty Crocker brigade to DIY techies. These women—and they were mostly women—became chemists and marketers, studied nutrition, health, and exercise, tested parachutes, created astronaut food, and took bold steps in childhood development and education. Home economics followed the currents of American culture even as it shaped them. Dreilinger brings forward the racism within the movement along with the strides taken by women of color who were influential leaders and innovators. She also looks at the personal lives of home economics’ women, as they chose to be single, share lives with other women, or try for egalitarian marriages. This groundbreaking and engaging history restores a denigrated subject to its rightful importance, as it reminds us that everyone should learn how to cook a meal, balance their account, and fight for a better world.

Author: Dan Blumenthal
Publisher: AEI Press
ISBN: 0844750328
Category : Political Science
Languages : en
Pages : 174

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This is a book about China's grand strategy and its future as an ambitious, declining, and dangerous rival power. Once the darling of U.S. statesmen, corporate elites, and academics, the People's Republic of China has evolved into America's most challenging strategic competitor. Its future appears increasingly dystopian. This book tells the story of how China got to this place and analyzes where it will go next and what that will mean for the future of U.S. strategy. The China Nightmare makes an extraordinarily compelling case that China's future could be dark and the free world must prepare accordingly.

Author: Robert Vitalis
Publisher: Stanford University Press
ISBN: 1503612341
Category : Political Science
Languages : en
Pages : 197

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“A valuable addition to the new wave of critical studies on the history of oil and energy policy”—and a bracing corrective to longstanding myths (James M. Gustafson, Diplomatic History). Conventional wisdom tells us that the US military presence in the Persian Gulf is what guarantees American access to oil; that the “special” relationship with Saudi Arabia is necessary to stabilize an otherwise volatile market; and that these assumptions in turn provide Washington enormous leverage over Europe and Asia. But the conventional wisdom is wrong. Robert Vitalis debunks the myths of “oilcraft”, a line of magical thinking closer to witchcraft than statecraft. Oil is a commodity like any other: bought, sold, and subject to market forces. Vitalis exposes the suspect fears of oil scarcity and investigates the geopolitical impact of these false beliefs. In particular, Vitalis shows how we can reconsider the question of the US-Saudi special relationship, which confuses and traps many into unnecessarily accepting what they imagine is a devil’s bargain. Freeing ourselves from the spell of oilcraft won’t be easy, but the benefits make it essential.

Author: Steffen Rupp
Publisher: Humana Press
ISBN: 9781617378249
Category : Science
Languages : en
Pages : 0

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In recent decades, infectious diseases, once believed to be fairly contained, have become a vital, resurgent field of research. In Host-Pathogen Interactions: Methods and Protocols, top experts examine the relationship between the host and the pathogen, crucial in the outcome of an infection and the establishment of disease or asymptomatic, commensal colonization by organisms. The step-by-step laboratory methods and protocols of this volume study host-pathogen interaction, with a focus on fungal, bacterial and parasitic pathogens, at a molecular level in order to reveal the mechanisms of infection and to identify the vulnerabilities of the pathogen of interest. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters feature brief subject introductions, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Host-Pathogen Interactions: Methods and Protocols serves as an easy entry point for all those investigating the factors responsible for the pathogenicity of microorganisms.