Industrial Crystallization Process Monitoring and Control PDF Download

Author: Angelo Chianese
Publisher: John Wiley & Sons
ISBN: 3527645179
Category : Science
Languages : en
Pages : 253

View

Book Description
Crystallization is an important technique for separation and purification of substances as well as for product design in chemical, pharmaceutical and biotechnological process industries. This ready reference and handbook draws on research work and industrial practice of a large group of experts in the various areas of industrial crystallization processes, capturing the essence of current trends, the markets, design tools and technologies in this key field. Along the way, it outlines trouble free production, provides laboratory controls, analyses case studies and discusses new challenges. First the instrumentation and techniques used to measure the crystal size distribution, the nucleation and solubility points, and the chemical composition of the solid and liquid phase are outlined. Then the main techniques adopted to control industrial crystallizers, starting from fundamental approaches to the most advanced ones, including the multivariable predictive control are described. An overview of the main crystallizer types is given with details of the main control schemes adopted in industry as well as the more suitable sensors and actuators.

Author:
Publisher: John Wiley & Sons
ISBN: 3527631348
Category : Technology & Engineering
Languages : en
Pages : 628

View

Book Description
Inspired by the leading authority in the field, the Centre for Process Systems Engineering at Imperial College London, this book includes theoretical developments, algorithms, methodologies and tools in process systems engineering and applications from the chemical, energy, molecular, biomedical and other areas. It spans a whole range of length scales seen in manufacturing industries, from molecular and nanoscale phenomena to enterprise-wide optimization and control. As such, this will appeal to a broad readership, since the topic applies not only to all technical processes but also due to the interdisciplinary expertise required to solve the challenge. The ultimate reference work for years to come.

Author: Mirko Skiborowski
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110720469
Category : Technology & Engineering
Languages : en
Pages : 584

View

Book Description
Process intensifi cation aims for increasing effi ciency and sustainability of (bio-)chemical production processes. This book presents strategies for the intensifi cation of fluid separation processes such as reactive distillation, reactive absorption and membrane assisted separations. The authors discuss theoretical fundamentals, model development, methods for synthesis and the design as well as scale-up and industrial process applications.

Author: Wolfgang Beckmann
Publisher: John Wiley & Sons
ISBN: 3527650342
Category : Science
Languages : en
Pages : 370

View

Book Description
Crystallization is a natural occurring process but also a process abundantly used in the industry. Crystallization can occur from a solution, from the melt or via deposition of material from the gas phase (desublimation). Crystals distinguish themself from liquids, gases and amorphous substances by the long-range order of its building blocks that entail the crystals to be formed of well-defined faces, and give rise to a large number of properties of the solid. Crystallization is used at some stage in nearly all process industries as a method of production, purification or recovery of solid materials. Crystallization is practiced on all scales: from the isolation of the first milligrams of a newly synthesized substance in the research laboratory to isolating products on the mulit-million tonne scale in industry. The book describes the breadth of crystallization operations, from isolation from a reaction broth to purification and finally to tailoring product properties. In the first section of the book, the basic mechanisms - nucleation, growth, attrition and agglomeration are introduced. It ensures an understanding of supersaturation, the driving force of crystallization. Furthermore, the solubility of the substance and its dependences on process conditions and the various techniques of crystallization and their possibilities and limitations are discussed. Last but not least, the first part includes an intensive treatment of polymorphism . The second part builds on the basics, exploring how crystallization processes can be developed, either batch-wise or continuous, from solution or from the melt. A discussion of the purification during crystallization serves as a link between the two sections, where practical aspects and an insight using theoretical concepts are combined. Mixing and its influence on the crystallization as well as the mutual interference of down-stream processes with the crystallization are also treated. Finally, techniques to characterize the crop are discussed. The third part of the book is dedicated to accounts of actual developments and of carried-out crystallizations. Typical pitfalls and strategies to avoid these as well as the design of robust processes are presented.

Author: H. Ohtaki
Publisher: John Wiley & Sons
ISBN:
Category : Science
Languages : en
Pages : 232

View

Book Description
An overview of crystallization processes of organic and inorganic substances from various homogeneous liquids. Crystal structures, phase transitions and crystallization rates are described in the book in connection with the structure of ions, complexes and molecules of the solution phase.

Author: Allan Myerson
Publisher: Butterworth-Heinemann
ISBN: 0080533515
Category : Technology & Engineering
Languages : en
Pages : 329

View

Book Description
Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes.The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design.Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the fieldCovers all aspects of industrial crystallization in a single, complete volume

Author:
Publisher: Elsevier
ISBN: 0444634428
Category : Technology & Engineering
Languages : en
Pages : 835

View

Book Description
This volume collects together the presentations at the Eighth International Conference on Foundations of Computer-Aided Process Design, FOCAPD-2014, an event that brings together researchers, educators, and practitioners to identify new challenges and opportunities for process and product design. The chemical industry is currently entering a new phase of rapid evolution. The availability of low-cost feedstocks from natural gas is causing renewed investment in basic chemicals in the OECD, while societal pressures for sustainability and energy security continue to be key drivers in technology development and product selection. This dynamic environment creates opportunities to launch new products and processes and to demonstrate new methodologies for innovation, synthesis and design. FOCAPD-2014 fosters constructive interaction among thought leaders from academia, industry, and government and provides a showcase for the latest research in product and process design. - Focuses exclusively on the fundamentals and applications of computer-aided design for the process industries. - Provides a fully archival and indexed record of the FOCAPD14 conference - Aligns the FOCAPD series with the ESCAPE and PSE series

Author: Ajit S. Narang
Publisher: CRC Press
ISBN: 100080447X
Category : Medical
Languages : en
Pages : 495

View

Book Description
Continuous manufacturing of pharmaceuticals, including aspects of modern process development is highlighted in this book with both the ‘why’ and the ‘how’, emphasizing process modeling and process analytical technologies. Presenting specific case studies and drawing upon extensive experience from industry and academic opinion leaders, this book focuses on the practical aspects of continuous manufacturing. It gives the readers the strategic perspective and technical depth needed to adopt and implement these technologies, where appropriate, in order to gain the competitive edge in speed, agility, and reliability. Features: Discusses scientific solutions and process analytical technology to enable continuous manufacturing in the development of new drugs Includes short stories about how some companies have adopted CM and what their drivers were and what benefits were realized Addresses economic and practical considerations, unlike many other technical books Emphasizes the practical aspects to give the reader the strategic imperative and technological depth to adopt and implement these technologies Highlights the "why" and the "how", focusing on the need analysis and process modeling and process analytical technologies

Author: Paul Serban Agachi
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110789868
Category : Technology & Engineering
Languages : en
Pages : 444

View

Book Description
As a mature topic in chemical engineering, the book provides methods, problems and tools used in process control engineering. It discusses: process knowledge, sensor system technology, actuators, communication technology, and logistics, design and construction of control systems and their operation. The knowledge goes beyond the traditional process engineering field by applying the same principles, to biomedical processes, energy production and management of environmental issues. The book explains all the determinations in the "chemical systems" or "process systems", starting from the beginning of the processes, going through the intricate interdependency of the process stages, analyzing the hardware components of a control system and ending with the design of an appropriate control system for a process parameter or a whole process. The book is first addressed to the students and graduates of the departments of Chemical or Process Engineering. Second, to the chemical or process engineers in all industries or research and development centers, because they will notice the resemblance in approach from the system and control point of view, between different fields which might seem far from each other, but share the same control philosophy.

Author: Hsien-Hsin Tung
Publisher: John Wiley & Sons
ISBN: 0470447788
Category : Science
Languages : en
Pages : 304

View

Book Description
Filled with industrial examples emphasizing the practical applications of crystallization methodologies Based on the authors' hands-on experiences as process engineers at Merck, Crystallization of Organic Compounds guides readers through the practical aspects of crystallization. It uses plenty of case studies and examples of crystallization processes, ranging from development through manufacturing scale-up. The book not only emphasizes strategies that have been proven successful, it also helps readers avoid common pitfalls that can render standard procedures unsuccessful. The goal of this text is twofold: Build a deeper understanding of the fundamental properties of crystallization as well as the impact of these properties on crystallization process development. Improve readers' problem-solving abilities by using actual industrial examples with real process constraints. Crystallization of Organic Compounds begins with detailed discussions of fundamental thermodynamic properties, nucleation and crystal growth kinetics, process dynamics, and scale-up considerations. Next, it investigates modes of operation, including cooling, evaporation, anti-solvent, and reactive crystallization. The authors conclude with special applications such as ultrasound in crystallization and computational fluid dynamics in crystallization. Most chapters feature multiple examples that guide readers step by step through the crystallization of active pharmaceutical ingredients (APIs). With its focus on industrial applications, this book is recommended for chemical engineers and chemists who are involved with the development, scale-up, or operation of crystallization processes in the pharmaceutical and fine chemical industries.