Prediction of Solubility in Supercritical Carbon Dioxide and Organic Polymeric Materials PDF Download

Author: 王立行
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Author: Ram B. Gupta
Publisher: CRC Press
ISBN: 1420005995
Category : Science
Languages : en
Pages : 960

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Supercritical fluid extraction is an environmentally safe and cost-effective alternative to traditional organic solvents. Carbon dioxide is widely used as the solvent of choice for applications such as caffeine and nicotine extraction due to its mild critical temperature, nontoxicity, nonflammability, and low cost. Introducing the most complete col

Author: Igor Pioro
Publisher: BoD – Books on Demand
ISBN: 183880708X
Category : Science
Languages : en
Pages : 224

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Book Description
Using SuperCritical Fluids (SCFs) in various processes is not new, because Mother Nature has been processing minerals in aqueous solutions at critical and supercritical pressures for billions of years. Somewhere in the 20th century, SCFs started to be used in various industries as working fluids, coolants, chemical agents, etc. Written by an international team of experts and complete with the latest research, development, and design, Advanced Supercritical Fluids Technologies is a unique technical book, completely dedicated to modern and advanced applications of supercritical fluids in various industries.Advanced Supercritical Fluids Technologies provides engineers and specialists in various industries dealing with SCFs as well as researchers, scientists, and students of the corresponding departments with a comprehensive overview of the current status, latest trends and developments of these technologies.Dr Igor Pioro is a professor at the University of Ontario Institute of Technology, Canada, and the Founding Editor of the ASME Journal of Nuclear Engineering and Radiation Science.

Author: Trevor M Letcher
Publisher: Royal Society of Chemistry
ISBN: 1847557686
Category : Science
Languages : en
Pages : 433

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Solubility is fundamental to most areas of chemistry and is one of the most basic of thermodynamic properties. It underlies most industrial processes. Bringing together the latest developments and ideas, Developments and Applications in Solubility covers many varied and disparate topics. The book is a collection of work from leading experts in their fields and covers the theory of solubility, modelling and simulation, industrial applications and new data and recent developments relating to solubility. Of particular interest are sections on: experimental, calculated and predicted solubilities; solubility phenomena in 'green' quaternary mixtures involving ionic liquids; molecular simulation approaches to solubility; solubility impurities in cryogenic liquids and carbon dioxide in chemical processes. The book is a definitive and comprehensive reference to what is new in solubility and is ideal for researcher scientists, industrialists and academics

Author: Maren L. Seibold
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Abstract: In the pharmaceutical industry, the production of solid dispersions is generally accepted as a method to enhance the oral bioavailability of drugs with low aqueous solubility. Two processes commonly employed to create solid dispersions are examined in this research. The first technique dissolves the drug and carrier in a common organic solvent and is followed by a solvent-removal operation. The second method processes both the drug and polymer in a high-pressure mixer with supercritical carbon dioxide. This method is intended to simulate the temperature and pressure conditions of carbon dioxide-assisted hot-melt extrusion. Organic solvent-based solid dispersion formulation techniques are accompanied by environmental challenges, due to disposal of the solvent, and are generally more costly than extrusion applications. However, the application of hot-melt extrusion technologies has been limited due to the temperature-sensitive nature of the drugs and the high processing temperatures associated with the extrusion process. The inclusion of supercritical fluids, such as carbon dioxide, in the polymer-melt extrusion method has proved to significantly lower processing temperatures, thereby extending the technique to thermo-labile compounds. Yet the properties of solid dispersions created in this manner have traditionally been unpredictable. This study systematically analyzes the properties of solid dispersions formulated by supercritical carbon dioxide-assisted techniques and compares these characteristics to those of solid dispersions created using the organic-solvent method. Composite samples of 4-aminosalicylic acid, a sample drug compound, and eudragit E100, an acrylate block copolymer, were formulated using both the organic solvent method and a carbon dioxide-assisted high-pressure mixing process. Due to the costly nature of the drug and polymer, the high-pressure mixer approach was employed to simulate extruder conditions in a batch operation and characterize the suitability of materials for extrusion. Drug-polymer composites were made using the organic-solvent method. The processing temperature of these samples was kept low so that it could be used as a standard to examine the effects of heat. In the high-pressure mixer technique, the same ratio of drug-polymer was processed with supercritical carbon dioxide. Process temperatures and carbon dioxide pressures were varied. Samples from each method were analyzed using differential scanning calorimetry (DSC) to measure thermal properties and Fourier-transform infrared (FTIR) spectroscopy to examine drug-polymer interactions and dispersion properties. High-pressure differential scanning calorimetry (HPDSC) was further utilized to examine the morphology of the composites while in equilibrium with carbon dioxide. Results of this study examine the use of a high-pressure mixer to simulate extrusion conditions and distinguish between composites made by organic solvent and supercritical carbon dioxide-assisted processes.

Author: Charles M. Hansen
Publisher: CRC Press
ISBN: 1420006835
Category : Science
Languages : en
Pages : 546

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Hansen solubility parameters (HSPs) are used to predict molecular affinities, solubility, and solubility-related phenomena. Revised and updated throughout, Hansen Solubility Parameters: A User's Handbook, Second Edition features the three Hansen solubility parameters for over 1200 chemicals and correlations for over 400 materials including p

Author: Gyorgy Szekely
Publisher: Elsevier
ISBN: 0128146826
Category : Technology & Engineering
Languages : en
Pages : 474

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Sustainable Nanoscale Engineering: From Materials Design to Chemical Processing presents the latest on the design of nanoscale materials and their applications in sustainable chemical production processes. The newest achievements of materials science, in particular nanomaterials, opened new opportunities for chemical engineers to design more efficient, safe, compact and environmentally benign processes. These materials include metal-organic frameworks, graphene, membranes, imprinted polymers, polymers of intrinsic microporosity, nanoparticles, and nanofilms, to name a few. Topics discussed include gas separation, CO2 sequestration, continuous processes, waste valorization, catalytic processes, bioengineering, pharmaceutical manufacturing, supercritical CO2 technology, sustainable energy, molecular imprinting, graphene, nature inspired chemical engineering, desalination, and more. Describes new, efficient and environmentally accepted processes for nanomaterials design Includes a large array of materials, such as metal-organic frameworks, graphene, imprinted polymers, and more Explores the contribution of these materials in the development of sustainable chemical processes

Author: Peter York
Publisher: CRC Press
ISBN: 0824751027
Category : Medical
Languages : en
Pages : 640

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Book Description
Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical products-from drug powders for respiratory delivery to drug delivery systems for controlled release.

Author: Jane Osborne
Publisher: Nova Science Publishers
ISBN: 9781633219304
Category : Fluids
Languages : en
Pages : 0

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Supercritical fluid carbon dioxide (sc-CO2) possesses both gas-like and liquid-like properties. It is capable of depositing nanoparticles in small structures and poorly wettable substrates. Deposition and array formation of metal and metal sulphide nanoparticles on various substrates using sc-CO2 as a medium has been a subject of considerable interest for researchers in nanomaterials area in recent years. This handbook begins by exploring nanoparticle deposition using supercritical fluid carbon dioxide. Further topics in this handbook include separation of oils using supercritical carbon dioxide; the application of an integrated supercritical extraction and impregnation process for incorporation of thyme extracts into different carriers; supercritical fluid extraction application on dairy products and by-products; and supercritical fluid technology applications in pharmaceutical drug formulations.

Author: E. Kiran
Publisher: Springer Science & Business Media
ISBN: 9401139296
Category : Science
Languages : en
Pages : 602

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Book Description
Supercritical fluids are neither gas nor liquid, but can be compressed gradually from low to high density and they are therefore interesting and important as tunable solvents and reaction media in the chemical process industry. By adjusting the density the properties of these fluids can be customised and manipulated for a given process - physical or chemical transformation. Separation and processing using supercritical solvents such as CO2 are currently on-line commercially in the food, essential oils and polymer industries. Many agencies and industries are considering the use of supercritical water for waste remediation. Supercritical fluid chromatography represents another, major analytical application. Significant advances have recently been made in materials processing, ranging from particle formation to the creation of porous materials. The chapters in this book provide tutorial accounts of topical areas centred around: (1) phase equilibria, thermodynamics and equations of state; (2) critical behaviour, crossover effects; (3) transport and interfacial properties; (4) molecular modelling, computer simulation; (5) reactions, spectroscopy; (6) phase separation kinetics; (7) extractions; (8) applications to polymers, pharmaceuticals, natural materials and chromatography; (9) process scale-up.