Precision Molecular Pathology of Aggressive B-Cell Lymphomas PDF Download

Author: Genevieve M. Crane
Publisher: Springer Nature
ISBN: 3031468422
Category :
Languages : en
Pages : 434

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Author: Genevieve M. Crane
Publisher: Springer
ISBN: 9783031468414
Category : Medical
Languages : en
Pages : 0

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Book Description
Written by experts in the field, Precision Molecular Pathology of Aggressive B-Cell Lymphomas contains the most recent revisions from the 5th Edition WHO and 2022 International Consensus Classification diagnostic categories and serves as an important resource for trainees, pathologists, haematologist/oncologists, other clinicians involved in lymphoma care and lymphoma researchers. It provides a comprehensive yet concise synthesis of emerging molecular advances that inform patient care and improve understanding of disease mechanisms. In addition, it provides the necessary background to how molecular techniques are performed to enable the reader to better interpret and critically evaluate relevant and emerging data. As part of the Molecular Pathology Library series, this book focuses specifically on aggressive B-cell lymphomas given the increasing relevance of molecular data for diagnosis and treatment of these disorders. This evidence-based text contains 25 chapters and is divided into 5 parts. Part 1 provides a brief history and background of aggressive B-cell lymphomas. Landmark events in their classification and treatment are given in order to place the substantial advances in the field in context. Part 2 reviews molecular pathology methods, including the increasing use of next generation sequencing techniques in clinical practice. Parts 3 and 4 focus on individual subtypes of aggressive B-cell lymphoma, including a summary of the diagnostic criteria and key pathologic and clinical features for each entity. Finally, Part 5 focuses on emerging molecular technologies that may significantly impact clinical practice.

Author: S. David Hudnall
Publisher: Springer
ISBN: 3319680943
Category : Medical
Languages : en
Pages : 239

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This text provides a comprehensive and up-to-date overview of Hodgkin lymphoma. The volume reviews every facet of the cancer in great detail, including pathology, pathobiology, molecular genetics, microenvironment, epidemiology, treatment, and new therapeutic advances. The specific role of the lymphoma microenvironment is addressed, and the relationship of Hodgkin lymphoma to related non-Hodgkin lymphomas is covered as well. Written by experts in the field, Precision Molecular Pathology of Hodgkin Lymphoma is a valuable resource for oncologists, surgeons, pathologists, clinical trainees, and investigators engaged in the diagnosis, treatment, and research studies of this lymphoid neoplasm.

Author: Larissa V. Furtado
Publisher: Springer
ISBN: 3319896261
Category : Medical
Languages : en
Pages : 360

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This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.

Author: Victor G. Prieto
Publisher: Springer
ISBN: 1493928619
Category : Medical
Languages : en
Pages : 142

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Book Description
This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology. The book includes descriptions of the techniques and their application to cutaneous diseases and describes possible future techniques and their use in dermatopathology. Special emphasis is also given to the practical application of these techniques to particular situations illustrated by demonstrative cases. Written by experts in their fields, Precision Molecular Pathology of Dermatologic Diseases is of great value to pathologists, dermatologists, resident and fellows, internists, and general practitioners who deal with dermatologic diseases.

Author: Georg Lenz
Publisher: Springer
ISBN: 3030003620
Category : Medical
Languages : en
Pages : 358

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Book Description
This book summarizes current knowledge of the biology and molecular pathogenesis of aggressive lymphomas and reviews the state of the art in diagnostic and therapeutic strategies. The aim is both to provide the reader with a sound understanding of the very significant progress that has been achieved in the understanding and management of these malignancies over recent years and to facilitate appropriate choice of the therapeutic strategy in individual cases. The assessment of different prognostic parameters are clearly presented in order to permits effective risk stratification that impacts on treatment choice. Recent insights into lymphomagenesis are exemplified and may assist in identifying emerging therapeutic targets. The comprehensive and up-to-date nature of the book will make it an ideal reference for all physicians and researchers interested in lymphoma, including clinicians from various medical specialties, biologists, pathologists, radiologists and nuclear medicine specialist, as well as students.

Author: Brian D. Robinson
Publisher: Springer
ISBN: 3319640968
Category : Medical
Languages : en
Pages : 564

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Book Description
This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.

Author: Xianfeng F. Zhao
Publisher: CRC Press
ISBN: 1040125425
Category : Medical
Languages : en
Pages : 243

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Book Description
Precision pathology of cancer is a new frontier - a systemic diagnostic approach to provide specific therapeutic targets and genetic and metabolic information for the treatment of patients. Not only are cancers extremely diverse but there is also heterogenetic variation among patients with the same cancer; owing to differences in genetic makeup and metabolic levels, a drug may work in one patient but be toxic in another. This text covers both basic concepts (the role of the precision pathologist, ethical issues, molecular basis, tools used in precision pathology, and specimen procurement) and clinical practice (the precise genes/pathways, ongoing clinical trials, therapeutics, pharmacogenomics, pharmacoproteomics, and pharmacometabolomics) in precision pathology of cancer. Covers both the conceptual bases and the clinical applications Enables pathologists, haematologists, and medical oncologists to apply Precision Pathology to their daily clinical practice Covers the whole range of cancers in practical detail

Author: Donna E. Hansel
Publisher: Springer
ISBN: 3319647695
Category : Medical
Languages : en
Pages : 245

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Book Description
This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.

Author: Owen A. O'Connor
Publisher: John Wiley & Sons
ISBN: 1119671310
Category : Medical
Languages : en
Pages : 434

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Book Description
THE PERIPHERAL T-CELL LYMPHOMAS Provides a comprehensive look at Peripheral T-Cell lymphomas, including the group’s unique geographic distribution, underlying genetics, and novel treatments Peripheral T-Cell lymphomas (PTCL) are a diverse group of lymphoid malignancies that develop from mature T cells and natural killer (NK) cells. PTCL represent 10-15% of all cases of non-Hodgkin lymphoma in the US, and up to 20-25% of cases in South America, Asia, and other regions around the world. The role of different etiologic factors and the variation of geographic distribution makes PTCL one of the most difficult types of cancer to understand and treat. For the first time in a single volume, The Peripheral T-Cell Lymphomas presents a comprehensive survey of this complex and rare group of blood cancers. Featuring contributions from an international team of leading authorities in the various aspects of PTCL, this authoritative text covers biology, epidemiology, classification, approved and emerging drugs, molecular genetics, and more. Detailed clinical chapters address diagnosis, prognosis, and treatment of each of the major PTCL subtypes identified in the 2018 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues. This much-needed resource: Covers the biological basis, epidemiology, classification, and treatment of PTCL Discusses the future of the field, including global collaboration efforts and novel approaches to PCTL Explores the role of biologics in PTCL and autologous and allogeneic stem-cell transplantation Offers new insights on molecular pathogenesis, innovative therapeutics, and novel drug combinations Features contributions from the Chairs The T-Cell Lymphoma Forum: the world’s largest meeting focused on PTCL Reflecting the unique epidemiology and genetic diversity of the PTCL, The Peripheral T-Cell Lymphomas is an indispensable source of data, insight, and references for the medical community, particularly oncologists and hematologists in both training and practice.