Pot, Atom, and Step Economy (PASE) Synthesis PDF Download

Author: Wei Zhang
Publisher: Springer
ISBN: 3030225968
Category : Science
Languages : en
Pages : 55

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Book Description
This book emphasizes the atom economy aspect of multicomponent reactions. It describes how this methodology has been applied to several named reactions. Among the “twelve principles of green chemistry”, atom economy addresses ‘synthetic efficiency’. A multicomponent reaction can be defined as an energy, cost, and time efficient method for organic synthesis. Instead of making one or two bonds in a chemical transformation, multicomponent reactions generate several chemical bonds in a single operation. This book presents a series of detailed reaction mechanisms that beautifully illustrate this principle. Multicomponent reactions are widely applied to the preparation of complex and diverse molecular structures in academic and industrial research laboratories. As such, this book is targeted at researchers involved in green organic chemistry.

Author: Erik Van der Eycken
Publisher: John Wiley & Sons
ISBN: 3527349081
Category : Science
Languages : en
Pages : 626

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Book Description
Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs. Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions. Provides a thorough overview of heterocycles as input in multicomponent reactions Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry Explains the methodology of using on-resin MCRs to produce heterocycle compounds Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.

Author: Raquel P. Herrera
Publisher: John Wiley & Sons
ISBN: 1118863976
Category : Science
Languages : en
Pages : 523

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Book Description
Addressing a dynamic aspect of organic chemistry, this book describes synthetic strategies and applications for multicomponent reactions – including key routes for synthesizing complex molecules. • Illustrates the crucial role and the important utility of multicomponent reactions (MCRs) to organic syntheses • Compiles novel and efficient synthetic multicomponent procedures to give readers a complete picture of this class of organic reactions • Helps readers to design efficient and practical transformations using multicomponent reaction strategies • Describes reaction background, applications to synthesize complex molecules and drugs, and reaction mechanisms

Author:
Publisher: Elsevier
ISBN: 0443297436
Category : Science
Languages : en
Pages : 270

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Book Description
Advances in Heterocyclic Chemistry, Volume 144 highlights new advances in the field, with this volume presenting chapters on Metal free C-H functionalization of aromatic and non-aromatic heterocyclic systems, Divergent Total Synthesis of Indolizidine-, Quinolizidine-, and Decahydroquinoline-type Poison-frog Alkaloids, A perspective on the synthetic potential of bio-based building blocks for heterocyclic chemistry, Recent advances in the synthesis of 3,3-disubstituted oxetanes, and Pyrrole-based chemosensors: Recent trends. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Heterocyclic Chemistry

Author: Pei-Qiang Huang
Publisher: John Wiley & Sons
ISBN: 1118940210
Category : Science
Languages : en
Pages : 512

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Book Description
Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Author: Gianfranco Favi
Publisher: MDPI
ISBN: 3036503404
Category : Medical
Languages : en
Pages : 372

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Book Description
Heterocycles feature widely in natural products, agrochemicals, pharmaceuticals and dyes, and their synthesis is of great interest to synthetic chemists in both academia and industry. The contributions of recent applications of new methodologies in C–H activation, photoredox chemistry, cross-coupling strategies, borrowing hydrogen catalysis, multicomponent and solvent-free reactions, regio- and stereoselective syntheses, as well as other new, attractive approaches for the construction of heterocyclic scaffolds are of great interest. This Special Issue is dedicated to featuring the latest research that is ongoing in the field of heterocyclic synthesis. It is expected that most submissions will focus on five- and six-membered oxygen and nitrogen-containing heterocycles, but structures incorporating other rings/heteroatoms will also be considered. Original research (communications, full papers and reviews) that discusses innovative methodologies for assembling heterocycles with potential application in materials, catalysis and medicine are therefore welcome.

Author: Lutz F. Tietze
Publisher: John Wiley & Sons
ISBN: 3527608680
Category : Science
Languages : en
Pages : 631

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Book Description
Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.

Author: John Andraos
Publisher: CRC Press
ISBN: 0429754426
Category : Science
Languages : en
Pages : 592

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Book Description
This book contains a series of exercises and problems posed in the subject of green metrics. Essentially it is a "how to" book on evaluating the material efficiency, environmental impact, safety-hazard impact, and energy efficiency of any kind of chemical reaction or synthesis plan. Only the essential green metrics in each of these categories are used. The introduction highlights the hierarchy of metrics used throughout the book, explains the structure of how the book is arranged, how the problems are posed, and how the reader is to use the book. Examples refer to themes according to the headings given in the table of contents and are arranged in a hierarchical order. Key Features: The topics cover fundamentals in chemistry and the chemical industry in a blended fashion A unique text covering the fundamentals of green metrics from materials efficiency and environmental and safety-hazard impact, to new green technologies and more The book will be useful in a range of chemistry courses, from early undergraduate to advanced graduate courses, whether based in lectures, tutorials or laboratory experiments Using an extensive glossary of terms used in green metrics, each chapter has a specified theme where the relevant metrics definitions pertaining to that theme will be given with one or two illustrative worked examples Supplemental web-based downloadable material including extra problems, full solutions, Excel files, ChemDraw files, templates, and exercises

Author: Howard Maskill
Publisher: John Wiley & Sons
ISBN: 0470994169
Category : Science
Languages : en
Pages : 392

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Book Description
A range of alternative mechanisms can usually be postulated for most organic chemical reactions, and identification of the most likely requires detailed investigation. Investigation of Organic Reactions and their Mechanisms will serve as a guide for the trained chemist who needs to characterise an organic chemical reaction and investigate its mechanism, but who is not an expert in physical organic chemistry. Such an investigation will lead to an understanding of which bonds are broken, which are made, and the order in which these processes happen. This information and knowledge of the associated kinetic and thermodynamic parameters are central to the development of safe, efficient, and profitable industrial chemical processes, and to extending the synthetic utility of new chemical reactions in chemical and pharmaceutical manufacturing, and academic environments. Written as a coherent account of the principal methods currently used in mechanistic investigations, at a level accessible to academic researchers and graduate chemists in industry, the book is highly practical in approach. The contributing authors, an international group of expert practitioners of the techniques covered, illustrate their contributions by examples from their own research and from the relevant wider chemical literature. The book covers basic aspects such as product analysis, kinetics, catalysis, and investigation of reactive intermediates. It also includes material on significant recent developments, e.g. computational chemistry, calorimetry, and electrochemistry, in addition to topics of high current industrial relevance, e.g. reactions in multiphase systems, and synthetically useful reactions involving free radicals and catalysis by organometallic compounds.

Author: Roberto Ballini
Publisher: Royal Society of Chemistry
ISBN: 1788018397
Category : Science
Languages : en
Pages : 432

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Book Description
The principles of Green Chemistry aim to improve the sustainability of chemical processes and reduce the generation of hazardous substances. There has been great growth in the field over the past few years and the number of research groups working in this area is still increasing. Now one of the biggest challenges is to embed the Green Chemistry ideals of safety and sustainability as standard, both in industry and academia. In order to do this, it is important to create resources that detail different applications and approaches. Green Synthetic Processes and Procedures brings together expert contributors from across a number of areas of green synthesis to cover a diverse array of subjects. Providing a thorough overview of the current green synthetic toolbox, from biocatalysis to sonochemistry, this book is a useful resource for any chemist wishing to design cleaner and safer processes.