Possible Mechanisms to Explain Abdominal Fat Loss Effect of Exercise Training Other Than Fatty Acid Oxidation PDF Download

Author: Chia-Hua Kuo
Publisher: Frontiers Media SA
ISBN: 2889719960
Category : Science
Languages : en
Pages : 130

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Author: Mario D. Cordero
Publisher: Springer
ISBN: 3319435892
Category : Medical
Languages : en
Pages : 523

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AMPK has emerged as an important integrator of signals that control energy balance through the regulation of multiple biochemical pathways in eukaryotes. This book focuses on the implications of AMPK as a master metabolic regulator in diseases, including new methods and animal models. The contributions are written by leading experts in the field and give an extensive overview of the current knowledge of AMPK biology and the role of AMPK in health and disease.

Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309089964
Category : Medical
Languages : en
Pages : 277

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The primary purpose of fitness and body composition standards in the U.S. Armed Forces has always been to select individuals best suited to the physical demands of military service, based on the assumption that proper body weight and composition supports good health, physical fitness, and appropriate military appearance. The current epidemic of overweight and obesity in the United States affects the military services. The pool of available recruits is reduced because of failure to meet body composition standards for entry into the services and a high percentage of individuals exceeding military weight-for-height standards at the time of entry into the service leave the military before completing their term of enlistment. To aid in developing strategies for prevention and remediation of overweight in military personnel, the U.S. Army Medical Research and Materiel Command requested the Committee on Military Nutrition Research to review the scientific evidence for: factors that influence body weight, optimal components of a weight loss and weight maintenance program, and the role of gender, age, and ethnicity in weight management.

Author: Atcharaporn Limprasertkul
Publisher:
ISBN:
Category :
Languages : en
Pages : 135

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The population aged 65 and older in the United State is anticipated to increase by 53% by 2020. Aging is associated with changes in body composition and metabolism resulting in decreased maximal oxygen consumption (VO2max). In addition, gender, inactivity and diet in elderly may increase the risk of diseases such as cardiovascular disease, hypertension, and diabetes. Among the potential mechanisms associated with these changes may be reduced fat oxidation (FO). The immune system affects the factors described above, and in turn there are age-related changes in immune function which may lead to immunosenescence, thereby increasing the chance for infections and risks for some diseases. A common treatment for metabolic disturbances and immune function is statin drugs which decrease low density lipoprotein cholesterol (LDL-C) and reduce the risk of cardiovascular events and may reduce inflammatory processes.^The purpose of this dissertation was to determine if FO was reduced in elderly, specifically after correcting for other factors (e.g. diet, activity level, reduced VO2max etc.), and to investigate the impact FO has on immune responses to stress (exercise), and finally the benefits and consequences of statin therapy.Hypotheses: The following hypotheses were tested: 1) Elderly will have reduced fat oxidation, even after correction for the reduced maximal aerobic power, compared to young subjects. 2) The reduced fat oxidation in the elderly will be associated with reduced release and uptake of fats for metabolism, compared to young. 3) Aerobic exercise training in the elderly will improve fat oxidation, but will not reach the same level as the young. 4) Elderly will have an exaggerated immune response to exercise stress, which will be reduced by exercise training.^5) Statin therapy will significantly reduce fat oxidation.Protocol: To test these hypotheses, a series of studies were conducted. First, a retrospective analysis of total body fat oxidation from a randomized controlled study that was designed to test the effectiveness of an aerobic exercise program in elderly was completed. Second, a study was conducted to test total body fat oxidation, substrate delivery and immune responses to exercise in the elderly compared to young. In addition, an aerobic training program was conducted with the elderly to examine the total body fat oxidation, substrate delivery and immune response before and after training.^Third, compare elderly subjects on statin therapy with a matched control group for the above variables.Methods: In the first study, total body FO during progressive VO2max test on a cycle ergometer in sedentary young and elderly subjects was compared and then the effect of aerobic exercise training on FO in elderly determined. Healthy young women (n = 12), men (n = 10), elderly women (n = 44) and elderly men (n = 44) completed a VO2max test. Respiratory exchange ratio (RER = VCO2/ VO2) was measured as an estimate of FO. Elderly women and men (n =22 each) completed 8 weeks of aerobic exercise training (1 hr, 3 sessions/wk) on a cycle ergometer. For the second study, FO, VO2max, blood lipids, and the immune response to exercise in elderly (N=14) compared to young (n=16) and elderly prior to and after aerobic exercise training (12 wks, 3 sessions/wk for 1 hr).^VO2max and sustained submaximal (70% of VO2max) exercise tests were completed, as were pre and post-exercise blood samples. For the last study, elderly on statin therapy (n = 14) were compared to elderly control subjects (n = 14). FO was determined during maximal and sustained submaximal exercise protocol. Blood samples were drawn for lipid analysis and immune function.Results: VO2 and RER increased linearly with exercise intensity for young and elderly. RER was significantly higher in women than men (p = 0.001), in both young and elderly (p = 0.001). At submaximal VO2, RER increased as a function of VO2, and in elderly the slope increased significantly more than young (young men, RER = 0.12 VO2 + 0.71; elderly men, RER = 0.27 VO2 + 0.71; young women, RER = 0.33 VO2 + 0.54; elderly women, RER = 0.49 VO2 + 0.60, RER/L/min).^Exercise training in elderly increased VO2max (20% in elderly women, 30% in elderly men) and decreased RER at submaximal VO2 in elderly men (RER = 0.21 VO2 + 0.75), but not for elderly women. These data were confirmed in the second study where young had significantly higher VO2max than elderly (30.3 " 6.7 ml/min/kg vs. 16.7 " 6.2 ml/min/kg, p = 0.001). Young also had lower RER at all VO2's than elderly; however, not after correction for VO2max. Young had longer sustained exercise duration (45.5 " 17.6 min) than elderly pre-training (30.2 " 14.0 min). None of the differences between young and elderly could be accounted for by diet or daily activity levels. After 12 weeks of aerobic training in elderly, there was a significant increase in VO2max (14.53 " 3.68 to 24.54 " 4.57 ml/min/kg, p = 0.001).^After training, fasting total cholesterol (TC, 193 " 43 mg/dL) and low density lipoprotein cholesterol (118 " 34 mg/dL) did not change, while triglycerides (TG) (81 " 36 mg/dL to 115 " 59 mg/dL, p = 0.009) increased. After the VO2max test, post-training, RER (slope = 0.012 vs. 0.016, p = 0.001) and blood lactate (31%, p = 0.028) were significantly lower, while glucose increased (7%, p = 0.04). TG increased by the VO2max test (10-15%) both pre and post-training. After training, submaximal exercise time (58.3 " 27.3 min vs. 30.2 " 14.0 min, p = 0.02), glucose (20%, p = 0.038) and TG increased (6-18%, p = 0.024), while RER was reduced (0.90 " 0.03 vs. 1.00 " 0.03, p = 0.04). Although total caloric intake was higher in young, the balance of carbohydrates, fats and proteins was similar in young and elderly (about 53, 26 and 19%, respectively). In young subjects, no cytokines were increased after the VO2max test.^After the submaximal test in young, IL-1 & beta; (8 " 4 pg/ml) and IL-10 (0.7" 0.6 pg/ml) were not affected by exercise, while IL-6 increased significantly (1.9 " 1.3 to 2.9 " 2.2 pg/ml). In elderly after VO2max test, IL-1 & beta; increased (7.9 " 1.4 to 8.9 " 5.5 pg/ml, p = 0.05) and IL-10 decreased (0.6 " 1.1 to 0.8 " 1.5 pg/ml, p = 0.04). There were no differences between cytokines in young and elderly subjects (p = 0.38 to 0.63). For elderly there were no significant effects of exercise on IL-1 & beta;, IL-6 or IL-10 after 12 weeks of training. In the last study, RER was significantly higher in subjects taking statins during both the VO2max and submaximal tests, indicating reduced FO. Blood lipoprotein levels during exercise were not affected by statins nor were levels of glucose, lactate, or TG. However, free fatty acid levels were significantly elevated by exercise. Statin therapy did not affect IL-1 & beta; or TNF- & alpha;, but increased IL-6.^Conclusions: FO was reduced in the elderly before training, and remained lower than young even after VO2max and FO were increased after training, particularly in women. Elderly did not have reduced fat availability from blood or FO after correction for VO2max during exercise on a treadmill, which increased after training; and sustained exercise duration increased; however this 12 week aerobic training had little effect on the cardiovascular risk factors measured in this study. Neither young nor elderly healthy untrained subjects demonstrated inflammatory responses to exercise and training. In addition, cytokine production was not significantly altered in elderly. It appears that factors other than age may negatively impact the immune system in elderly subjects, i.e. diet, inactivity, diseases, etc.^Although statin therapy lowers baseline blood lipoproteins, its secondary effects need further consideration as FO was significantly reduced in elderly, and this could not be accounted for by diet, exercise, fitness or availability of fat from the blood.

Author: Manfred Lamprecht
Publisher: CRC Press
ISBN: 1466567570
Category : Medical
Languages : en
Pages : 304

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The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Author: K. Rao Poduri
Publisher: CRC Press
ISBN: 1482211238
Category : Medical
Languages : en
Pages : 678

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Geriatric Rehabilitation addresses the fact that this is an age in which individuals have increasing longevity, better health care, education and expectations of health care which present new, increasing and even radical challenges to health care providers. The care of our older patients in rehabilitation settings demands the broad understanding of the key differences in strategies to care for older adults. The combined skills embraced in rehabilitation and geriatrics are presenting unprecedented opportunities for both fields to make substantive and even ground-breaking improvements in the lives of millions of older adults who entrust their lives to us. Rarely in one’s medical career are such opportunities so evident and achievable. Geriatric Rehabilitation edited by Dr. K. Rao Poduri, MD. FAAPMR draws on a distinguished group of authors who are the front-line providers of care to the older adults. This book presents the full spectrum of the unique care needs of older patients who need the combined skills of physical medicine and geriatrics. It provides an easily accessible means of acquiring and improving these new skills for all those involved in geriatric care.

Author: Jack Feehan
Publisher: Academic Press
ISBN: 0323885764
Category : Science
Languages : en
Pages : 482

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Book Description
Exercise to Prevent and Manage Chronic Disease Across the Lifespan provides evidence-based insights into the clinical utility of exercise in the management of disease across a broad range of specialties and diseases. The book offers research informed strategies for the integration of exercise into standard practice in fields such as neurology, endocrinology, psychiatry and oncology, as well as decision-making pathways and clinical scenarios to advance patient care. The book is divided by specialty and includes clinical scenarios to allow for the integration of information within practice. The book's synthesized research evidence allows practitioners to safely and effectively begin to capitalize on the benefits of exercise in their patients. Provides broad insights into the evidence-based underpinnings of the use of exercise in a range of common diseases Coverage includes the immune system, musculoskeletal disease, oncology, endocrinology, cardiology, respiratory diseases, and more Includes a glossary, bibliography and summary figures for quick reference of information

Author: Moran S. Saghiv
Publisher: Springer Nature
ISBN: 3030488063
Category : Medical
Languages : en
Pages : 582

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This book reviews the assessment of human performance and the role of different exercise modes both in a laboratory and clinical setting. Details of how to successfully perform basic laboratory procedures for exercise training in health and disease, as well as how to apply non-invasive measurements in exercise physiology are provided. Chapters cover how to appropriately use a range of measures in assessing pulmonary function, anaerobic function and oxygen uptake. Techniques for cardiopulmonary rehabilitation and the mechanisms associated with thermoregulation are also described. Interactive exercises enable readers to easily assimilate key concepts and develop a thorough understanding of the topic. Basic Exercise Physiology provides both trainees and professional healthcare staff interested in exercise physiology with a detailed and practically applicable resource on the topic.

Author: Asker E. Jeukendrup
Publisher: Human Kinetics Publishers
ISBN: 9780736079624
Category : Health & Fitness
Languages : en
Pages : 475

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Book Description
The new edition of "Sport Nutrition: An Introduction to Energy Production and Performance" presents the principles, background, and rationale for current nutrition guidelines specifically for athletes. Using a physiological basis, this text provides an in-depth look at the science behind sport nutrition. Students will come away with a comprehensive understanding of nutrition as it relates to sport and the influence of nutrition on exercise performance, training, and recovery. The chapters and the material within each chapter are sequenced in a logical order that will help instructors deliver a better course and spend less time in preparing lectures and tutorials. Instructors will also enjoy the completely new ancillaries with this edition, including an online instructor guide, test package, PowerPoint presentation package, and image bank. This text contains updated and expanded information to keep students current on the latest findings in sport nutrition: - A new chapter on training adaptations, including effects of nutrition on overtraining - New information on weight management and body composition for athletes - New research on carbohydrate and new recommendations for carbohydrate intake during training - An expanded discussion on the role of protein in strength and endurance exercise training - The latest information on exercise, nutrition, and immune function The new content complements the strong foundational information that the authors provided in the previous edition, including fuel sources for muscle and exercise metabolism, energy requirements for various sports, and a complete grounding in the macronutrients (carbohydrate, fat, and protein) and the micronutrients (vitamins and minerals). With more than 200 illustrations, new highlight boxes, and tables and sidebars throughout the text, students will be able to more easily grasp the scientific concepts presented in this text. Each chapter also includes learning objectives, key terms, and key points to help readers retain the information. The text presents not only nutrition principles but also the exercise biochemistry involved and the energy needs of athletes. Readers will better understand how supplements may be used in an athlete's diet, and they will learn how to separate fact from fallacy regarding the claims of the numerous nutritional supplements available today. More than a simple prescription of recommendations, this second edition of" Sport Nutrition" features a unique presentation that facilitates readers' understanding of the science supporting the nutrition recommendations. As a result, students will be prepared for advanced study and future careers, and professionals will gain the knowledge and confidence to provide sound advice to athletes.

Author: Babak Mokhlesi
Publisher: Elsevier Health Sciences
ISBN: 0323326811
Category : Medical
Languages : en
Pages : 201

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This issue on Hypoventilation Syndrome covers a variety of topics such as Sleep hypoventilation: Diagnostic considerations and technological limitations,Pathophysiology of hypoventilation during sleep,Advances in PAP treatment modalities for hypoventilation syndromes,Scoring abnormal respiratory events on polysomnography during noninvasive ventilation,OHS Epidemiology and diagnosis,OHS outcomes,Non-PAP treatment modalities in OHS, Pulmonary overlap syndromes,Noninvasive ventilation during sleep in stable COPD and more!