Portable Magnetic Resonance Sensors and Methods for Noninvasive Disease Diagnostics PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Portable Magnetic Resonance Sensors and Methods for Noninvasive Disease Diagnostics PDF full book. Access full book title Portable Magnetic Resonance Sensors and Methods for Noninvasive Disease Diagnostics by Ashvin Reddy Bashyam. Download full books in PDF and EPUB format.
Author: Ashvin Reddy Bashyam Publisher: ISBN: Category : Languages : en Pages : 154
Book Description
Many diseases manifest as a shift in fluids between distinct tissue fluid compartments. For example, fluid depletion and fluid overload lead to a deficit or accumulation of fluids within the intramuscular interstitial space. A direct measurement of these fluid shifts could serve as a highly specific diagnostic or prognostic tool to improve clinical management of these disorders. Proton magnetic resonance is exquisitely sensitive to the local physical and chemical environment of water molecules within the body. Therefore, we hypothesized that localized magnetic resonance (MR) measurements could interrogate local tissue fluid distributions and assess systemic fluid volume status. This thesis explored the potential for a portable MR sensor to characterize shifts in tissue fluid distribution and identify the onset and progression of fluid volume status disorders. First, we designed a portable, single sided MR sensor capable of performing remote measurements of the multicomponent T2 signal originating from distinct fluid compartments. Further, we present a design framework to create single sided sensors with magnetic field strength and geometry suitable for a wide range of applications. We then demonstrate that a localized measure of tissue fluid distribution using a portable MR sensor is capable of identifying systemic changes in fluid volume status associated with fluid depletion. We validate these findings via whole animal MR measurements and a standard MRI scanner capable of localizing its measurement towards the muscle tissue. Finally, we explore new strategies to enable the translation of these portable MR sensors towards humans. We demonstrate techniques combining multicomponent T2 relaxometry, depth-resolved measurements, and diffusion-weighted pulse sequences to improve identification of fluid shifts within muscle tissue despite the presence of confounding tissues, such as the subcutaneous tissue. The magnetic resonance sensors and measurement techniques developed here lay the foundations for a non-invasive, portable, and quantitative indicator of tissue fluid distribution. This technology has the potential to serve as a clinical diagnostic for both localized and systemic fluid imbalances. Furthermore, these approaches enabling portable, quantitative MR measurements can be extended to the diagnosis and staging of the progression of other diseases which exhibit shifts in fluid distributions.
Author: Ashvin Reddy Bashyam Publisher: ISBN: Category : Languages : en Pages : 154
Book Description
Many diseases manifest as a shift in fluids between distinct tissue fluid compartments. For example, fluid depletion and fluid overload lead to a deficit or accumulation of fluids within the intramuscular interstitial space. A direct measurement of these fluid shifts could serve as a highly specific diagnostic or prognostic tool to improve clinical management of these disorders. Proton magnetic resonance is exquisitely sensitive to the local physical and chemical environment of water molecules within the body. Therefore, we hypothesized that localized magnetic resonance (MR) measurements could interrogate local tissue fluid distributions and assess systemic fluid volume status. This thesis explored the potential for a portable MR sensor to characterize shifts in tissue fluid distribution and identify the onset and progression of fluid volume status disorders. First, we designed a portable, single sided MR sensor capable of performing remote measurements of the multicomponent T2 signal originating from distinct fluid compartments. Further, we present a design framework to create single sided sensors with magnetic field strength and geometry suitable for a wide range of applications. We then demonstrate that a localized measure of tissue fluid distribution using a portable MR sensor is capable of identifying systemic changes in fluid volume status associated with fluid depletion. We validate these findings via whole animal MR measurements and a standard MRI scanner capable of localizing its measurement towards the muscle tissue. Finally, we explore new strategies to enable the translation of these portable MR sensors towards humans. We demonstrate techniques combining multicomponent T2 relaxometry, depth-resolved measurements, and diffusion-weighted pulse sequences to improve identification of fluid shifts within muscle tissue despite the presence of confounding tissues, such as the subcutaneous tissue. The magnetic resonance sensors and measurement techniques developed here lay the foundations for a non-invasive, portable, and quantitative indicator of tissue fluid distribution. This technology has the potential to serve as a clinical diagnostic for both localized and systemic fluid imbalances. Furthermore, these approaches enabling portable, quantitative MR measurements can be extended to the diagnosis and staging of the progression of other diseases which exhibit shifts in fluid distributions.
Author: Christopher John Frangieh Publisher: ISBN: Category : Languages : en Pages : 51
Book Description
Portable, non-invasive sensors of tissue fluid distribution would aid in diagnosis of fluid volume disorders and inform therapeutic decisions across diverse patient populations. Existing techniques are inaccurate, invasive, or easily confounded by patient physiology. Single-sided magnetic resonance (MR) devices could provide a portable, low-cost platform for localized measurements of fluid distribution. This thesis demonstrates a single-sided MR sensor that can quantify fluid distribution of heterogeneous samples via depth-resolved, diffusion-weighted, multicomponent T2 relaxometry. Validation using synthetic tissue phantoms, ex vivo tissue samples, and an in vivo edema model is presented. Estimation of tissue fractions in heterogeneous samples with 2% error and tissue layer thickness with 0.1 mm error is demonstrated. The sensor can identify onset, progression, and recovery of muscle edema despite the presence of a confounding subcutaneous tissue layer. These methods can provide point-of-care diagnostics for fluid distribution disorders such as end-stage renal disease and dehydration.
Author: Jayashankar Das Publisher: Academic Press ISBN: 0323905331 Category : Technology & Engineering Languages : en Pages : 472
Book Description
Biosensors for Emerging and Re-Emerging Infectious Diseases provides a review of how cornerstone optical, electronic, nanomaterial and data processing technologies can address detection issues occurring in a pandemic event. This book gives insights into the fundamental physical, chemical and biological mechanisms needed for such a type of detection. The content covers potential biomarkers which can be used for the infectious disease diagnostic, helping readers find the appropriate approach for the diagnosis of infectious diseases. It presents a novel approach to transferring the sensing platform from lab to application in clinics and to point of care detection. The book then moves on to discuss the function and efficiency of the biosensing platform in early diagnosis of infectious diseases compared to the standard methods. The required time, the technician skills and the steps which must be performed are other key factors of the biosensing platform which are well explained. Covers applications of biosensors in diagnostics and detection of infection, and in the application of new materials in biosensor development Presents nano-biosensor based point-of-care technologies Introduces readers to the fundamentals of biosensors for infectious diseases
Author: Robert B. Northrop Publisher: CRC Press ISBN: 1420041207 Category : Medical Languages : en Pages : 544
Book Description
Noninvasive medical diagnosis (NIMD) is as old as medical practice itself. From the earliest healers' observations of odors, skin color, and breath sounds to today's wealth of technologies, the basics remain the same and keep the role of NIMD essential to effective medical care. Noninvasive Instrumentation and Measurement in Medical Diagnos
Author: Pawan Kumar Maurya Publisher: Woodhead Publishing ISBN: 0323851657 Category : Technology & Engineering Languages : en Pages : 432
Book Description
Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system – offering targeted and detailed diagnostic results in a range of biomedical applications. This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing. Covers core principles and nano-approaches in bioanalytics for medical diagnostics Details a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including spectroscopic analysis, erythrocyte models, microfluidics, and more Appeals to an interdisciplinary readership, spanning the fields of materials science, biomedical engineering and biochemical engineering
Author: Madan M Kaila Publisher: Elsevier ISBN: 0123847125 Category : Science Languages : en Pages : 517
Book Description
Magnetic resonance imaging (MRI) is a medical imaging technique used to visualize detailed internal structure of the body. This book discusses the recent developments in the field of MRI and its application to the diagnosis of human brain disorders. In addition, it reviews the newly emerging concepts and technology, based on the multi-coherence imaging (MQCI). It explains how computer packages can be used to generate images in diseased states and compare them to in vivo results. This will help improve the diagnosis of brain disorders based on the real-time events happening on atomic and molecular quantum levels. This is important since quantum-based MRI would enable clinicians to detect brain tumors at the very early stages. Uses practical examples to explain the techniques - making it easier to understand the concepts Uses diagrams to explain the physics behind the technique - avoiding the use of complicated mathematical formulae
Author: Federico Casanova Publisher: Springer Science & Business Media ISBN: 3642163076 Category : Technology & Engineering Languages : en Pages : 254
Book Description
This book describes the design of the first functioning single-sided tomograph, the related measurement methods, and a number of applications in medicine, materials science, and chemical engineering. It will be the first comprehensive account of this new device and its applications. Among the key advances of this method is that images can be obtained in much shorter times than originally anticipated, and that even vector maps of flow fields can be measured although the magnetic fields are highly inhomogeneous. Furthermore, the equipment is small, mobile and affordable to small and medium enterprises and can be located in doctors’ offices.
Author: Nilanjan Dey Publisher: Academic Press ISBN: 012819362X Category : Technology & Engineering Languages : en Pages : 322
Book Description
Sensors for Health Monitoring discusses the characteristics of U-Healthcare systems in different domains, providing a foundation for working professionals and undergraduate and postgraduate students. The book provides information and advice on how to choose the best sensors for a U-Healthcare system, advises and guides readers on how to overcome challenges relating to data acquisition and signal processing, and presents comprehensive coverage of up-to-date requirements in hardware, communication and calculation for next-generation uHealth systems. It then compares new technological and technical trends and discusses how they address expected u-Health requirements. In addition, detailed information on system operations is presented and challenges in ubiquitous computing are highlighted. The book not only helps beginners with a holistic approach toward understanding u-Health systems, but also presents researchers with the technological trends and design challenges they may face when designing such systems. Presents an outstanding update on the use of U-Health data analysis and management tools in different applications, highlighting sensor systems Highlights Internet of Things enabled U-Healthcare Covers different data transmission techniques, applications and challenges with extensive case studies for U-Healthcare systems
Author: Sushma Dave Publisher: Elsevier ISBN: 0323900666 Category : Technology & Engineering Languages : en Pages : 596
Book Description
Advanced Nanomaterials for Point of Care Diagnosis and Therapy provides an overview of technological and emerging novel trends in how point-of-care diagnostic devices are designed, miniaturized built, and delivered at different healthcare set ups. It describes the significant technological advances in fundamental diagnostic components and recent advances in fully integrated devices designed for specific clinical use. The book covers state-of-the-art fabrication of advances materials with broad spectrum therapeutic applications. It includes drug delivery, biosensing, bioimaging and targeting, and outlines the development of inexpensive, effective and portable in vitro diagnostics tools for any purpose that can be used onsite. Sections also discuss drug delivery, biosensing, bioimaging and targeting and various metal, metal oxide and non-metal-based nanomaterials that are developed, surface modified, and are being explored for diagnosis, targeting, drug delivery, drug release and imaging. The book concludes with current needs and future challenges in the field. Outlines the needs and challenges of point-of-care diagnostics Describes the fundamentals of application of nanomaterials as interesting building blocks for biosensing Overviews the different detection methods offered by using nanomaterials Explains the advantages and drawbacks of nanomaterial-based sensing strategies Describes the opportunities offered by technology as a cost-efficient biosensing platform
Author: Ashvin Reddy Bashyam
Author: Ashvin Reddy Bashyam
Author: Christopher John Frangieh
Author: Robert H. Morris
Author: Jayashankar Das
Author: Robert B. Northrop
Author: Pawan Kumar Maurya
Author: Madan M Kaila
Author: Federico Casanova
Author: Nilanjan Dey
Author: Sushma Dave