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Author: James C. Lamb Publisher: Elsevier ISBN: 1483272079 Category : Medical Languages : en Pages : 283
Book Description
Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.
Author: James C. Lamb Publisher: Elsevier ISBN: 1483272079 Category : Medical Languages : en Pages : 283
Book Description
Physiology and Toxicology of Male Reproduction is a collection of papers that deals with general reproductive biology and specific aspects of reproductive toxicology, pertaining to the male sex. Some papers discuss testicular organization, reproductive toxicity testing systems, and germ-cell genetic toxicology. The use of in vitro systems by investigators to dissect the male reproductive toxicants can lead to a more scientific approach toward hazard assessment and the development of safer drugs and chemicals. Other papers explain the fundamental reproductive biology of the testis, the neuroendocrine system, the epididymis and accessory sex organs, and spermatozoal evaluation. Toxicological aspects cover the toxicological evaluation of the complete reproductive system, testicular morphology, sperm assessment, and germ-cell mutagenesis. One paper describes alternative methods in toxicology—by using new in vitro systems that should reduce or eliminate the need for tests conducted on animals. In vitro methodology embraces other systems such as from subcellular fractions to isolated intact organs. In relation to target-organ toxicity, the researcher can focus using primary cell cultures. This collection will prove helpful to toxicologists, graduate students and researchers in biology, particularly in male reproductive toxicology and fertility testing.
Author: Kavindra Kumar Kesari Publisher: Springer Nature ISBN: 3030893405 Category : Medical Languages : en Pages : 384
Book Description
This book discusses the role of oxidative stress in human reproduction with a focus on men’s health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men’s health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.
Author: P R Working Publisher: CRC Press ISBN: 9780891165835 Category : Medical Languages : en Pages : 365
Book Description
This reference work focuses on the practice of reproductive toxicology, providing a foundation in basic male and female reproductive physiology for the application and improvement of existing model systems.
Author: Robert E. Chapin Publisher: Elsevier ISBN: 1483270955 Category : Medical Languages : en Pages : 405
Book Description
Methods in Toxicology, Volume 3: Male Reproductive Toxicology, Part A, deals with the male reproductive system and discusses methods that will help identify toxicant-induced changes at all levels in living organisms. It is important to realize that a toxic effect does not occur in a vacuum. All work in toxicology must be predicated on a demonstrated adverse effect in vivo. If good toxicology cannot exist in a vacuum, then there must be a structure. Thus, the book begins by presenting a few models as examples of the ways experiments could be grouped to define the toxicity of a chemical. This is followed by separate chapters on methods such as male mouse sexual behavior test; in vitro techniques for assessing pituitary secretory function; histological methods for preservation of the rat testis; procedures for assessing testicular sperm head counts in mice, rats, and dogs; and guidelines for conducting rodent dominant lethal tests. Subsequent chapters cover topics such as methods for the isolation and purification of Leydig cells from rat and mouse testes, and techniques used in semen analysis and fertility assessment in the rabbit.
Author: Shubhadeep Roychoudhury Publisher: Springer Nature ISBN: 3031129660 Category : Medical Languages : en Pages : 347
Book Description
Volume Two advances the exploration of the fundamental principles of oxidative stress and toxicity on male (and female) reproduction. It includes the advances in research on male reproductive health, the impact of environmental factors, the protective measures using bioactive compounds and traditional medicines, and how to limit toxic exposure. It includes coverage of: Oxidative stress and male infertility Environmental stressors and sexual health Heavy metals, pesticides, fine particle toxicity and male reproduction Protective measures against oxidative stress in gametes/embryos by using bioactive compounds/phytomedicines in Assisted Reproductive Technology (ART) Role of reactive oxygen species on female reproduction Radiation and mutagenic factors affecting the male reproductive system Both volumes provide a comprehensive look at the most basic concepts and advanced research being conducted by world famous scientists and researchers in male infertility and reproduction.
Author: National Research Council Publisher: National Academies Press ISBN: 9780309039796 Category : Social Science Languages : en Pages : 424
Book Description
Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.
Author: Anthony R. Scialli Publisher: McGraw-Hill Companies ISBN: Category : Human reproduction Languages : en Pages : 360
Book Description
One of the most popular areas in toxicology is environmental toxicology & its effects on human fertility. Designed as a clinical reference, this book focuses on both the mechanisms of reproductive failure (male & female) & the clinical techniques for assessing & monitoring the effects of various toxicants on the reproductive process. Section I provides a basic overview of the toxicologic effects of various agents on male & female reproductive physiology & the process of conception. Section II builds on this background & covers the mechanisms of toxicant action, describing the ways in which normal reproduction may become deranged. Section III describes clinical & epidemiological methods by which fertility can be monitored & by which reproductive toxicity might be identified.
Author: Marco G. Alves Publisher: ISBN: 9781681085012 Category : Languages : en Pages :
Book Description
This text book comprehensively covers the physiology and biochemistry of the processes in the male reproductive system. Readers will gain an understanding of a variety of general topics relevant to andrology through fourteen chapters which include information about male reproductive anatomy, sexual development, spermatogenesis, sperm-egg interactions necessary for fertilization, reproductive toxicology, congenital disorders, sexually transmitted diseases, male sterility and changes due to aging.The book serves as a primary andrology reference for medical students studying reproductive biology.
Author: James C. Lamb
Author: James C. Lamb
Author: Kavindra Kumar Kesari
Author: P R Working
Author: Robert E. Chapin
Author: Shubhadeep Roychoudhury
Author: National Research Council
Author: Anthony R. Scialli
Author: Marco G. Alves
Author: Jerrold J. Heindel
Author: JJ Heindel (Ed)