Physiology and Physiopathology of Adipose Tissue PDF Download

Author: Jean-Philippe Bastard
Publisher: Springer Science & Business Media
ISBN: 2817803434
Category : Medical
Languages : en
Pages : 432

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Book Description
The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.

Author: Naveed Sattar
Publisher: John Wiley & Sons
ISBN: 1444312707
Category : Medical
Languages : en
Pages : 64

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Book Description
Obesity is a hugely expensive and increasing problem worldwide,leading to disability, reproductive problems, depression andaccelerated metabolic and vascular diseases in a large proportionof men, women and children. The ABC of Obesity is a newguide which will aid its effective management, addressing issuessuch as dieting, exercise, self esteem, drug treatment and surgery.Recent evidence is used to highlight frequent problems, successfultreatment options, and the most common causes. Written by leading experts, this is a widely accessible text andan indispensable guide for all general practitioners, juniordoctors, nurses, and other healthcare professionals who areinvolved in the treatment and research of this commoncondition.

Author: Todd Leff
Publisher: John Wiley & Sons
ISBN: 9783527629534
Category : Science
Languages : en
Pages : 530

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Book Description
This timely and most comprehensive reference available on the topic covers all the different aspects vital in the fight against the global obesity epidemic. Following a look at adipose tissue development and morphology, the authors go on to examine its metabolic and endocrine functions and its role in disease. The final section deals with comparative and evolutionary aspects of the tissue. The result is an essential resource for cell and molecular biologists, physiologists, biochemists, pharmacologists, and those working in the pharmaceutical industry.

Author: Saverio Cinti
Publisher:
ISBN: 9788885030329
Category : Medical
Languages : en
Pages : 94

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Book Description

Author: Ayse Basak Engin
Publisher: Springer
ISBN: 331948382X
Category : Science
Languages : en
Pages : 618

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Book Description
Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.

Author: Jean-Pierre Montmayeur
Publisher: CRC Press
ISBN: 1420067761
Category : Medical
Languages : en
Pages : 646

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Book Description
Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se

Author: Yihai Cao
Publisher: Springer Science & Business Media
ISBN: 1461480698
Category : Medical
Languages : en
Pages : 374

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Book Description
Angiogenesis has recently played a critical role in regulation of adipose tissue expansion and regression. Like most other tissues in the body, adipose expansion and regression is accompanied by alteration of blood vessel density and structures. The vascular alteration plays an active role in regulation of adipose tissue size and functions. Targeting blood vessels in the adipose tissue have demonstrated to be a novel approach for possibly treatment of cancer, obesity and other metabolic diseases. This book provides the most updated information on this type research and discusses future opportunities for therapy..

Author: Joana Vieira Silva
Publisher: Springer Nature
ISBN: 3030444368
Category : Medical
Languages : en
Pages : 444

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Book Description
Signal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters. This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors. Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author: Clark M. Blatteis
Publisher: World Scientific
ISBN: 9789810231729
Category : Science
Languages : en
Pages : 316

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Book Description
This is a user-friendly monograph designed for medical students as well as graduate students and postdoctoral trainees in medicine and other health-related sciences who need a comprehensive overview of thermoregulation. It presents the bases of the modern concepts in thermal physiology and pathophysiology, bringing together the disciplines encompassed by this highly integrative field ? physiology, anatomy, biophysics, molecular and cellular biology, pharmacology, neuroscience, pathology, medicine, and others ? into a clear and concise form that can be read comfortably in a relatively short time. This text was conceived by the Commission on Thermal Physiology of the International Union of Physiological Sciences in response to its concern over the inadequate and outdated coverage of this topic in traditional textbooks. The membership of this Commission comprises international experts in each of the subfields of thermal physiology, with extensive research and teaching experience in their respective specialties. They are the authors of the chapters of this indispendable textbook.

Author: Saverio Cinti
Publisher:
ISBN: 9783319405216
Category : Adipose tissues
Languages : en
Pages : 455

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Book Description
This richly illustrated book provides a detailed description of the gross anatomy, light microscopy, immunohistochemistry, and electron microscopy of the adipose organ, which comprises subcutaneous and visceral fat depots. Findings in mice of differing genetic backgrounds (obesity prone and resistant) and maintained in standard and various physiologic and pathologic conditions are presented. The latter conditions include chronic cold exposure, warm exposure, fasting, pregnancy-lactation, and obesity. Features of the fetal adipose organ are described in a separate chapter, and results from transgenic mice are also presented when relevant. The human adipose organ is addressed in several chapters that include magnetic resonance and fetal findings. Most of the results regarding the adipose organ anatomy in different physiologic conditions are new, and the story of pink adipocytes (white-to-pink transdifferentiation) is quite innovative. The concept of using browning of the adipose organ as a therapeutic tool for obesity must take into consideration the anatomic and morphologic aspects described here, and the study of pink adipocytes could lead to a better comprehension of breast cancer tumor biology. This book will be of interest to all scientists who deal with obesity and related disorders.