Diagnosis, Management and Emerging Strategies for Chemotherapy-Induced Neuropathy PDF Download

Author: Maryam Lustberg
Publisher: Springer Nature
ISBN: 3030786633
Category : Medical
Languages : en
Pages : 265

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Book Description
This book comprehensively examines chemotherapy-induced peripheral neuropathy (CIPN), a common dose-limiting condition that negatively affects both the quality of life of cancer patients and disease outcomes. CIPN remains a challenging area for both clinical care and research, as there are multiple unresolved issues. Written by leading international experts, the book discusses the natural history of CIPN, the latest predictors of toxicity, instruments for evaluating symptoms, and prevention/therapeutic strategies, as well as patients’ experiences of this common clinical syndrome. Lastly it highlights avenues for future research to enhance our understanding of CIPN. Providing essential information on the management of CIPN and the latest research in the field, this book is a valuable resource for researchers and healthcare providers working with patients with various malignant diseases.

Author: Michael C. Sanders
Publisher:
ISBN:
Category :
Languages : en
Pages : 29

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Book Description
BACKGROUND AND PURPOSE: As survival rates increase among individuals diagnosed with cancer, secondary issues arise post-treatment such as cancer-related fatigue, lymphedema, genitourinary dysfunction, pain and peripheral neuropathies, mainly chemotherapy-induced peripheral neuropathy (CIPN). CIPN typically presents with primarily sensory-related deficits including numbness, tingling, and pain. Studies have shown that the negative consequences of CIPN can be quite significant and result in a marked decrease in quality of life, functional abilities, ambulation and an increase in fall risk. The purpose of this case report is to describe the comprehensive physical therapy management of a patient diagnosed with CIPN following bilateral mastectomy with left axillary lymph node resection and chemotherapy with taxane agents, completed six months prior to physical therapy evaluation. CASE DESCRIPTION: The patient was a 52 year old Caucasian female who was referred to physical therapy for management of CIPN associated pain, balance and functional deficits. The patient reported numbness, tingling, and pain in bilateral feet, rating pain at a 4/10 at rest and 7/10 with increased activity. Patient reported occasional dizziness when fatigued and a decline in balance during ADL-related task and positional changes especially notable in low light situations. Sensory organization testing (SOT) on the NeuroCom system revealed deficits in conditions #5 and #6 with a composite score of 68; 3% below age norms. Patient reported difficulty with stairs, floor transfers and relied on upper extremities for balance with sit to stand transfers. She was unable to complete her custodial job due to deficits. Interventions included a trial of TENS and a referral for Calmare pain therapy or ?scrambler therapy?, manual lymph drainage and compression garments for lymphedema management, and dynamic balance activities including the use of unstable surfaces, narrow base of support conditions, eyes open/eyes closed conditions, and incorporation of head turns with functional activities. OUTCOMES: The patient requested to be discharged on her 9th physical therapy session stating that she felt she had made significant progress in both her balance, restoration of functional abilities and reduction of bilateral foot pain which she rated 3-4/10 with activity. Patient reported being pain free for 24-36 hours after ?Scrambler Therapy?. Furthermore, the patient cited no dizziness or perception of instability in low light settings or during positional changes. The patient also demonstrated improvements from 37-71 on the vestibular component. She was also able to return to work. DISCUSSION: This patient progressed well throughout physical therapy and presented with findings that warrant further research. Specifically, this report agrees with a study by Wampler et al reporting that postural instability in breast cancer survivors was likely due to the patients’ inability to appropriately use their vestibular input. Although no studies report vestibular toxicity following taxane use there has been research suggesting a vestibular component to those patients post-chemo treatment who presented with postural instability. Finally, the few studies published regarding the efficacy of ?Scrambler? therapy in patients with CIPN have shown promising results. The patient in this case report benefitted from the use of this pain modality.

Author: Amir Abdel-Raouf Fadl
Publisher:
ISBN:
Category :
Languages : ar
Pages : 131

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Book Description

Author: Robert B. Raffa
Publisher: CRC Press
ISBN: 1439862192
Category : Health & Fitness
Languages : en
Pages : 225

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Book Description
There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early

Author: Elizabeth R Andersen Hammond
Publisher:
ISBN:
Category :
Languages : en
Pages : 0

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Book Description
Chemotherapy induced peripheral neuropathy (CIPN) can have lasting sensory effects for cancer survivors. At present, the mechanisms causing the neuropathy are unknown and few effective treatment options are available. This thesis includes a review of the literature and four studies. The first study evaluated the potential role for physical therapy and nerve gliding home exercises to improve symptoms of CIPN and explored whether a dual nerve disorder was present between the surgical and non-surgical side in a population with breast cancer. The nerve gliding exercises had a positive effect on pain as measured by the numeric pain rating scale (NPRS) and pain pressure algometry. No quantitative sensory testing (QST) data could identify a possible dual nerve disorder from surgery combined with chemotherapy. The second trial sought to confirm the effectiveness of electro acupuncture on improving chronic neuropathic pain from CIPN. This trial showed the ineffectiveness of electro acupuncture for chronic CIPN pain symptoms. The third study used the physical therapy study data to define the sensory phenotypes of neuropathic and non-neuropathic symptom profiles. This was completed to identify future targets for mechanism-based treatment. Surprisingly, only left hand heat pain threshold differences were observed on the QST measures. As expected, increased pain (measured by the NPRS) and decreased function (measured by the Disability of the Shoulder, Arm and Hand (DASH)) were observed in the neuropathic group. Using the physical therapy data, the fourth study correlated active participants with preservation of nerve function exploring the possible neuroprotective effect of exercise on CIPN. 'Active' versus 'less active' groups revealed significantly improved vibration perception and normalized heat pain thresholds for the active group suggesting possible neuroprotection among exercisers. This thesis helps to direct evidence-based practice and contributes to the literature. Our findings indicate that electro acupuncture should not be pursued as a treatment option for patients experiencing chronic pain from CIPN. Our findings support the use of physical therapy, nerve gliding exercises, and general exercise during and after chemotherapy. Physical therapy and nerve gliding exercises help reduce the symptoms associated with chemotherapy induced peripheral neuropathy while maintaining physical activity throughout treatment may provide neuroprotection.

Author: Shinichiro Morishita
Publisher: Springer Nature
ISBN: 9811967105
Category : Medical
Languages : en
Pages : 571

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Book Description
This collection of chapters describes in detail the physical therapy research in patients with various types of cancers to help medical professionals and physical therapists help improve the physical function, activity of daily living, quality of life, the survival rate in cancer patients and cancer survivors. It provides not only information on rehabilitation but details on physical therapy cancer research and research methods. The book provides practical skills to treat the patients and to create useful and effective physical therapy programs by giving step-by-step tutorials to help readers learn various techniques. Along with presenting an introduction to physical therapy of cance and new findings, the authors provide recommendations on each cancer therapy. Physical Therapy and Research in Patients with Cancer is aimed at physical therapists and student physical therapists. Undergraduate and postgraduate students also can use our book to understand the basics and get up-to-date information. By sharing the latest research with our readers, the book creates a foundation for further development in this field of study.

Author: David S. Butler
Publisher: Noigroup Publications
ISBN: 0975091026
Category : Medical
Languages : en
Pages : 435

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Book Description
The decade since the publication of David Butler's Mobilisation of the Nervous System has seen the rapid growth and influence of the powerful and linked forces of the neurobiological revolution, the evidence based movements, restless patients and clinicians. The Sensitive Nervous System calls for skilled combined physical and educational contributions to the management of acute and chronic pain states. It offers a "big picture" approach using best evidence from basic sciences and outcomes data, with plenty of space for individual clinical expertise and wisdom.

Author: Michael O'Dell, MD
Publisher: Demos Medical Publishing
ISBN: 1935281380
Category : Medical
Languages : en
Pages : 1130

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Book Description
A Doody's Core Title 2012 This new comprehensive reference provides a state-of-the-art overview of the principles of cancer care and best practices for restoring function and quality of life to cancer survivors. Authored by some of the world« leading cancer rehabilitation experts and oncology specialists, the principles section provides primer level discussions of the various cancer types and their assessment and management. The practice section thoroughly explores the identification, evaluation, and treatment of specific impairments and disabilities that result from cancer and the treatment of cancer.This groundbreaking volume enables the entire medical team to provide superior care that results in a better quality of life for cancer survivors. Features include: Multi-specialty editorship and authorship from physiatry, oncology, physical therapy, occupational therapy,and related disciplines. Focus on therapeutic management of cancer-related impairments and complications. In-depth treatment of the medical, neurologic, musculoskeletal, and general rehabilitation issues specific to this patient population.

Author: Donald Abrams
Publisher: Oxford University Press
ISBN: 0199885850
Category : Medical
Languages : en
Pages : 916

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Book Description
People facing a new diagnosis of cancer are unsettled by their prognosis and treatment options, and they often seek to integrate complementary modalities into their conventional care plan, hoping to improve their chances of cure and decrease side effects. Many do so without informing their oncologist, for fear of alienating them or not convinced that their physician would be informed about complementary therapies. Integrative Oncology, the first volume in the Weil Integrative Medicine Library, provides a wealth of information for both practitioners and consumers on the emerging field of integrative oncology. Noted oncologist Donald Abrams and integrative medicine pioneer Andrew Weil and their international panel of experts present up-to-date and extensively referenced chapters on a wide spectrum of issues and challenges, bound in one comprehensive, reader-friendly text in a format featuring key points, sidebars, tables, and a two-color design for ease of use. It is destined to emerge as the definitive resource in this emerging field.

Author: Kathryn H. Schmitz
Publisher: Springer Nature
ISBN: 3030420116
Category : Medical
Languages : en
Pages : 438

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Book Description
This groundbreaking book presents a unique and practical approach to the evolving field of exercise oncology - the study of physical activity in the context of cancer prevention and control. Presenting the current state of the art, the book is sensibly divided into four thematic sections. Following an opening chapter presenting an overview and timeline of exercise oncology, the chapters comprising part I discuss primary cancer prevention, physical activity and survivorship, and the mechanisms by which these operate. Diagnosis and treatment considerations are discussed in part II, including prehabilitation, exercise during surgical recovery, infusion and radiation therapies, and treatment efficacy. Post-treatment and end-of-life care are covered in part III, including cardio-oncology, energetics and palliative care. Part IV presents behavioral, logistical and policy-making considerations, highlighting a multidisciplinary approach to exercise oncology as well as practical matters such as reimbursement and economics. Written and edited by experts in the field, Exercise Oncology will be a go-to practical resource for sports medicine clinicians, family and primary care physicians, oncologists, physical therapy and rehabilitation specialists, and all medical professionals who treat cancer patients.