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Author: Sandeep K. Kalva Publisher: ISBN: 9781510636620 Category : Acoustic imaging Languages : en Pages : 60
Book Description
This Spotlight discusses photoacoustic imaging (PAI) techniques and highlights the importance of pulsed laser diodes (PLDs). The text introduces the basic principle, signal detection, and various implementations. Computed tomography systems and their instrumentation are also addressed. Other topics include alternative laser sources , high-pulse repetition rate, pulse duration, signal-to-noise ratio, and safety.
Author: Sandeep K. Kalva Publisher: ISBN: 9781510636620 Category : Acoustic imaging Languages : en Pages : 60
Book Description
This Spotlight discusses photoacoustic imaging (PAI) techniques and highlights the importance of pulsed laser diodes (PLDs). The text introduces the basic principle, signal detection, and various implementations. Computed tomography systems and their instrumentation are also addressed. Other topics include alternative laser sources , high-pulse repetition rate, pulse duration, signal-to-noise ratio, and safety.
Author: Mithun Kuniyil Ajith Singh Publisher: Springer Nature ISBN: 9811539847 Category : Science Languages : en Pages : 393
Book Description
This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.
Author: Lihong V. Wang Publisher: CRC Press ISBN: 1351834983 Category : Science Languages : en Pages : 1027
Book Description
Photoacoustics promises to revolutionize medical imaging and may well make as dramatic a contribution to modern medicine as the discovery of the x-ray itself once did. Combining electromagnetic and ultrasonic waves synergistically, photoacoustics can provide deep speckle-free imaging with high electromagnetic contrast at high ultrasonic resolution and without any health risk. While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this book is the first comprehensive volume in this emerging field covering both the physics and the remarkable noninvasive applications that are changing diagnostic medicine. Bringing together the leading pioneers in this field to write about their own work, Photoacoustic Imaging and Spectroscopy is the first to provide a full account of the latest research and developing applications in the area of biomedical photoacoustics. Photoacoustics can provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. It can also provide high-contrast functional imaging of angiogenesis and hypermetabolism in tumors in vivo. Discussing these remarkable noninvasive applications and so much more, this reference is essential reading for all researchers in medical imaging and those clinicians working at the cutting-edge of modern biotechnology to develop diagnostic techniques that can save many lives and just as importantly do no harm.
Author: Sergei A Gurevich Publisher: World Scientific ISBN: 9814497061 Category : Science Languages : en Pages : 215
Book Description
This book is composed of seven invited papers which present the current status of high speed diode lasers. Fast carrier and photon dynamics in directly modulated MQW lasers is analyzed and novel design approaches are considered which were critical for the demonstration and record of 40 GHz modulation bandwidth. Attention is centered on the challenges in creation of high speed and low chirp single mode DFB lasers. Recent progress in mode-locked diode lasers is covered, specifically by the examples of 160 fs pulse generation and appearance of microwave pulse repetition rates. Future trends in increasing of high speed laser performance are also examined.
Author: Yu Wang Publisher: ISBN: Category : Electronic dissertations Languages : en Pages : 76
Book Description
Photoacoustic tomography, which detects non-radiative decay, is an emerging biomedical imaging modality that can provide 3D ultrasonically scalable images of biological tissue ranging from organelles to organs. Pure optical imaging modalities (e.g., optical coherence tomography and diffuse optical tomography) encounter a fundamental limitation of either penetration or spatial resolution at depths beyond one optical transport mean free path (~1 mm) due to strong light scattering by biological tissue. Photoacoustic imaging, however, provides a high ultrasonic spatial resolution for deep imaging by utilizing ultrasonic detection of the photoacoustic waves generated by absorbed diffuse light. By exploiting the rich optical absorption contrasts of biomolecules, photoacoustic imaging has been used to image both biological structure (e.g., internal organs and sentinel lymph nodes) and function (e.g., tumor hypoxia and brain oxygenation). The ability of photoacoustic imaging (photoacoustic microscopy and photoacoustic computed tomography) systems, to render three-dimensional volumetric images relies on illuminating light-absorbing chromophores using a pulsed laser system and recording the photoacoustic time-of-flight signals on a twodimensional surface facing the photoacoustic source. My doctoral research focuses on hardware advances in both exciting and detecting photoacoustic signals. Förster resonance energy transfer (FRET) imaging in deep biological tissue using photoacoustic techniques is also explored. This first part of my dissertation presents some novel photoacoustic excitation and detection technologies implemented in photoacoustic imaging. Fiber lasers have been proposed as a fast and compact alternative to current excitation sources for photoacoustic imaging, especially in the clinical environment. Its intrinsic optical-fiberbased amplification and output make the system easy to maintain. We developed a 1064 nm photoacoustic microscope based on a fiber laser system, which features a pulse repetition rate of 50 kHz. We demonstrated detection of circulating melanoma cells in blood. Photoacoustic and fluorescence imaging provide complementary optical absorption and fluorescence contrasts, respectively. We developed a dual modality imaging system that combines photoacoustic and fluorescence microscopy. The two sub-systems are naturally integrated by sharing the same laser source, objective lens and image scanner. We reported in vivo imaging of hemoglobin oxygen saturation and oxygen partial pressure in single blood vessels. Spectral (multi-wavelength) photoacoustic imaging must possess high wavelength-switching speed when applied in dynamic functional imaging. We implemented a digital-mirror-device (DMD)-based spectral-encoding photoacoustic imaging system. As a wavelength multiplexing element, DMD features a fast frame rate and pixelated manipulation flexibility. Compared with internal wavelength tuning of a narrow-band laser, external wavelength tuning based on a digital mirror device improves the data acquisition speed of spectral photoacoustic microscopy. Compared with external wavelength scanning of a wide-band laser with the same pulse energy, spectral encoding improves the signal-to-noise ratio. A twodimensional (2D) array transducer can acquire three-dimensional (3D) photoacoustic imaging without mechanical scanning; therefore, by using a small number of laser firings, higher imaging frame rates can be achieved. We presented an integrated photoacoustic and ultrasonic 3D volumetric imaging system based on a modified commercial ultrasound imaging system (iU22, Philips Healthcare) with a 2D array transducer (X7-2, Philips Healthcare). The imaging system enables rendering of coregistered 3D ultrasound and photoacoustic images. In vivo 3D photoacoustic mapping of the sentinel lymph node using methylene blue dye was demonstrated in a rat model. The second part of my dissertation focuses on photoacoustic Förster resonance energy transfer (FRET) imaging. FRET provides fluorescence signals sensitive to intra- and inter-molecular distances in the 1-10 nm range. Widely applied in the optical imaging environment, FRET enables visualization of physicochemical processes in molecular interactions and conformations. We reported photoacoustic imaging of FRET, based on non-radiative decay that produces heat and subsequent acoustic waves. The experimental results show that photoacoustic imaging, through its ability to threedimensionally image tissue with scalable resolution, provides a beneficial biomedical tool to broaden the in vivo application of the FRET technique.
Author: Huabei Jiang Publisher: CRC Press ISBN: 1482261049 Category : Science Languages : en Pages : 304
Book Description
The concept of photoacoustic tomography (PAT) emerged in the mid-1990s, and the field of PAT is now rapidly moving forward. Presenting the research of a well-respected pioneer and leading expert, Photoacoustic Tomography is a first-of-its-kind book covering the underlying principles and practical applications of PAT in a systematic manner. Written in a tutorial format, the text: Addresses the fundamentals of PAT, the theory on photoacoustic effect, image reconstruction methods, and instrumentation Details advanced methods for quantitative PAT, which allow the recovery of tissue optical absorption coefficient and/or acoustic properties Explores the development of several image-enhancing schemes, including both software and hardware approaches Examines array-based PAT systems that are the foundation for the realization of 2-D, 3-D, and 4-D PAT Discusses photoacoustic microscopy (PAM) and combinations of PAT/PAM with other imaging methods Considers contrast-agents-based molecular PAT, with both nontargeted and cell receptor–targeted methods Describes clinical applications and animal studies in breast cancer detection, osteoarthritis diagnosis, seizure localization, intravascular imaging, and image-guided cancer therapy Photoacoustic Tomography is an essential reference for graduate students, researchers, industry professionals, and those who wish to enter this exciting field.
Author: Sandeep K. Kalva
Author: Sandeep K. Kalva
Author: Mithun Kuniyil Ajith Singh
Author: Lihong V. Wang
Author: Sergei A Gurevich
Author: Yu Wang
Author: Minghua Xu
Author: Huabei Jiang
Author: Wenfeng Xia
Author: Alexander A. Oraevsky
Author: Huikai Xie