Phosphate and Borate Bioactive Glasses PDF Download

Author: Akiko Obata
Publisher: Royal Society of Chemistry
ISBN: 183916476X
Category : Technology & Engineering
Languages : en
Pages : 297

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Book Description
Inorganic glasses are successfully used in the biomedical field, in particular degradable glasses have found applications in tissue engineering, bone regeneration and tooth remineralisation. Silicate glasses are the most commonly used ones but phosphate and borate glasses are attracting more and more interest owing to their special properties, differing from those of silicate bio-glasses. Phosphate and borate glasses thus open up potential routes for new therapeutic applications. This book focuses on these emerging materials. Bridging the phosphate and borate glasses communities, this book provides a fundamental treatment of atomic structure and physicochemical properties before highlighting their current and potential future applications. Phosphate and borate glasses not only feature a broader range of glass formation than silicate glasses. Their ability to completely dissolve in water with the solubility varying over orders of magnitude with compositional changes, makes them exciting materials for delivering therapeutic agents into the human body. Biomaterials scientists working in glasses, hard tissue engineering and regenerative medicine will find this a must-have book to own, alongside their more traditional silicate glass tomes.

Author: Jaime Lynn George
Publisher:
ISBN:
Category : Borates
Languages : en
Pages : 176

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Book Description
"Borate glasses have been developed for biomedical applications such as scaffolds for soft tissue and bone repair. The dissolution processes of borate glasses in phosphate-containing aqueous solutions were studied by [mu]-Raman spectroscopy which provided information about the types and concentrations of borate species released into the solution as a function of time and characterized the formation of calcium phosphate reaction products on the glass surface. Boric acid molecules (H3BO3) and borate anions (B(OH)4−) can be detected in solution and their relative concentrations depend on the solution pH. Static and dynamic single-pass flow-through experiments were employed to study the dissolution kinetics of a borate bioactive glass 13-93B3 in water, simulated body fluid (SBF), and other solutions. As the glasses react, B-, Ca-, Na-, K-, Mg-, and P-species were released from the glass and a magnesium-containing amorphous calcium phosphate (ACP) or hydroxyapatite (HAP) layer formed on the surface of the glass. The formation of crystalline hydroxyapatite was favored with faster flow rates, longer reaction times, and increased phosphate concentration in solution. Under static conditions, the dissolution rates are initially described by a reaction-controlled model (linear kinetics), but after the glass is ~25-30% reacted, a diffusion-controlled model (parabolic kinetics) better describes the dissolution rates. The change in reaction mechanism is attributed to the diffusion of species from the glass through the ACP layer. The activation energy for the reaction-controlled process is 41.1±0.6 kJ/mol, whereas the activation energy for the diffusion process is 32.3±0.1 kJ/mol. For the SPFT experiments, glasses dissolved faster under faster flow rates and smaller glass volumes. The ion release rate was calculated and found to range from 1.7x10−5 g/m2/s for slow flow rates to 1.1x10−3 g/m2/s for lower glass volumes."--Abstract, page iv.

Author: Gurbinder Kaur
Publisher: Woodhead Publishing
ISBN: 0081021976
Category : Technology & Engineering
Languages : en
Pages : 584

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Book Description
Biomedical, Therapeutic and Clinical Applications of Bioactive Glasses is an essential guide to bioactive glasses, offering an overview of all aspects of the development and utilization of this cutting-edge material. The book covers vital issues, including mesoporosity, encapsulation technologies, scaffold formation and coatings for a number of applications, including drug delivery, encapsulation, scaffolds and coatings. Readers will gain a strong understanding and practical knowledge of the therapeutic aspects of bioceramics, with a focus on glasses from a clinical point-of- view. Researchers, students and scientists involved in bioceramics, bone tissue engineering, regeneration and biomedical engineering will find this to be a comprehensive resource. Presents detailed coverage of bioactive glasses, including technologies and applications Includes all the major development areas related to bioactive glasses, enabling readers to understand the latest research Considers the potential future developments of bioactive glasses as a drug carrier

Author: Francesco Baino
Publisher: John Wiley & Sons
ISBN: 111972466X
Category : Technology & Engineering
Languages : en
Pages : 904

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Book Description
Bioactive Glasses and Glass-Ceramics Fundamentals and Applications A Comprehensive and Critical Overview of Bioactive Glasses and Glass-Ceramics Bioactive glasses and glass-ceramics are a versatile class of biocompatible materials that have an astonishing impact in biomedicine. Bioactive Glasses and Glass-Ceramics: Fundamentals and Applications presents topics on the functional properties, processing, and applications of bioactive glasses and glass-ceramics. The primary use of bioactive glasses and glass-ceramics is to repair bone and dental defects; however, their full potential is yet to be fulfilled. Many of today’s achievements in regenerative medicine and soft tissue healing were unthinkable when research began. As a result, the research involving bioactive glasses and glass-ceramics is highly stimulating and continuously progresses across many different disciplines including chemistry, materials science, bioengineering, biology, and medicine. Topics relating to these disciplines and covered within the work include: Fundamentals on bioactive glasses and glass-ceramics, bioactive glasses in today’s market, and improvements and challenges for the future Scalability and other issues when taking bioactive glass from lab to industry/commercialization applications, plus clinical challenges Trending topics such as bioactive glass porous scaffolds, additive manufacturing of bioactive glasses, and nano-engineering of bioactive glasses The various bioactive glass compositions which have been developed as medical products in an expanding range of forms and applications Bioactive Glasses and Glass-Ceramics: Fundamentals and Applications serves as a comprehensive and complete reference work on bioactive glasses and glass-ceramics for research and development (R&D) materials scientists, surgeons, and physicians, and leadership at glass and medical companies. Students and professors in fields of study pertaining to the aforementioned disciplines will also derive value from the work.

Author: Gurbinder Kaur
Publisher: Springer
ISBN: 3319457160
Category : Technology & Engineering
Languages : en
Pages : 346

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Book Description
This book describes the history, origin and basic characteristics of bioactive materials. It includes a chapter dedicated to hydroxyapatite mineral, its formation and its bioactive properties. The authors address how cytotoxicity is a determining step for bioactivity. Applications of bioactive materials in the contexts of tissue regeneration, bone regeneration and cancer therapy are also covered. Silicate, metallic and mesoporous glasses are described, as well as the challenges and future prospects of research in this field.

Author: Heimo Ylänen
Publisher: Woodhead Publishing
ISBN: 0081009372
Category : Technology & Engineering
Languages : en
Pages : 428

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Book Description
Bioactive Glasses: Materials, Properties and Applications, Second Edition provides revised, expanded and updated content on the current status of this unique material, including its properties, technologies and applications. The book is suitable for those active in the biomaterials and bioengineering field, and includes eight new chapters that cover material types, computational modeling, coatings and applications. Chapters deal with the materials and mechanical properties of bioactive glass and the applications of bioactive glasses, covering their uses in wound healing, maxillofacial surgery and bone tissue engineering, among other topics. With its distinguished editor and expert team of international contributors, the book is an invaluable reference for researchers and scientists in the field of biomaterials, both in academia and industry. Provides a detailed review of bioactive glasses, their properties, technologies and applications Comprehensively covers the materials and mechanical properties of bioactive glass and their further applications, including wound healing, maxillofacial surgery and bone tissue engineering Suitable for those active in the biomaterials and bioengineering field

Author: Julian Jones
Publisher: John Wiley & Sons
ISBN: 1118346467
Category : Science
Languages : en
Pages : 294

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Book Description
This new work is dedicated to glasses and their variants which can be used as biomaterials to repair diseased and damaged tissues. Bio-glasses are superior to other biomaterials in many applications, such as healing bone by signaling stem cells to become bone cells. Key features: First book on biomaterials to focus on bio-glasses Edited by a leading authority on bio-glasses trained by one of its inventors, Dr Larry Hench Supported by the International Commission on Glass (ICG) Authored by members of the ICG Biomedical Glass Committee, with the goal of creating a seamless textbook Written in an accessible style to facilitate rapid absorption of information Covers all types of glasses, their properties and applications, and demonstrates how glass is an attractive improvement to current procedures Of interest to the biomedical as well as the materials science community. The book covers all types of glasses: traditional glasses, bioactive glasses, sol-gel glasses, phosphate glasses, glass-ceramics, composites and hybrids. Alongside discussion on how bio-glasses are made, their properties, and the reasons for their use, the authors also cover their applications in dentistry, bone regeneration and tissue engineering and cancer treatment. Its solid guidance describes the steps needed to take a new material from concept to clinic, covering the essentials of patenting, scale-up, quality assurance and FDA approval.

Author: Aldo R. Boccaccini
Publisher: Royal Society of Chemistry
ISBN: 1782629769
Category : Health & Fitness
Languages : en
Pages : 550

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Book Description
The field of bioactive glasses has been expanding continuously over recent years. This book aims to give the material's scientist an up-to-date reference and guide for education, studies and research.

Author: Marina N. Richard
Publisher:
ISBN:
Category : Bioactive compounds
Languages : en
Pages : 280

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Book Description
"For the past 30 years, the bioactive characteristics of special glass compositions have been demonstrated. Until now, phosphate containing soda-lime-silicate glasses such a 45S5 Bioglass®, were used to stimulate bone repair. Through the formation of an osteoconductive layer of hydroxyapatite (the main inorganic compound of bone) on the glass surface, direct bonding with bone will then occur. The rate of formation of hydroxyapatite was studied for the first silica-free borate glass of composition analogue to 45S5 and for a partially crystallized 45S5 glass. An cell-free process has been modeled to assess the formation of hydroxyapatite on the glass. The process involves the reaction of borate glass particles in phosphate solution of various molarity and starting pH. The formation of hydroxyapatite was observed best in a 0.1 Molar phosphate solution for both glasses. The reaction products have been investigated using X-ray diffraction (XRD), Infrared (IR) spectroscopy, Scanning Electron Microscopy (SEM) and Energy Dispersive Spectroscopy (EDS) and Inductively Coupled Plasma - Atomic Emission Spectrometer (ICP). The positive outcome of the model lead to further investigation of the borate glass. In vitro experiments were performed using MC3T3-E1 bone cells. The borate glass provided a marginally suitable environment for the growth of cells due to the release of boron. Successful in vivo experiments demonstrated bone growth around the borate glass particles very similar to that for the commercially used 45S5 glass. The successful bioactive response obtained with the first silica-free glass composition opens the way to the development of other compositions for bioactive use. Based on our study, future medical applications of a bioactive borate glass may dramatically reduce the rehabilitation time for patients"--Abstract, leaf iv.

Author: Juliana Marchi
Publisher: Springer
ISBN: 331944249X
Category : Technology & Engineering
Languages : en
Pages : 338

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Book Description
This book focuses on the applications of bioglasses in the biomedical field. It starts with the history and evolution of bioglasses before moving on to the structure and percolation theory, and lastly investigating their current and potential future applications in various fields including dentistry, tissue engineering, bone regeneration, ophthalmology, and drug delivery. The chapters were written by a team of international experts in the field and will be of great interest not only to material scientists, but also to medical doctors and other health sector professionals.