Author: Jāmiʻat al-Kuwayt. Department of Pharmacology
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description

Author: Roland N. Pittman
Publisher: Biota Publishing
ISBN: 1615047212
Category : Medical
Languages : en
Pages : 117

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Book Description
This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Author: Marilyn J. Cipolla
Publisher: Biota Publishing
ISBN: 1615047239
Category : Medical
Languages : en
Pages : 82

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Book Description
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Author: O. Thulesius
Publisher:
ISBN:
Category : International Symposium on Pharmacology of Human Blood Vessels
Languages : en
Pages : 387

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Book Description

Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0

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Book Description

Author: Michitoshi Inoue
Publisher: Springer Science & Business Media
ISBN: 4431683674
Category : Medical
Languages : en
Pages : 330

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Book Description
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0

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Book Description

Author: C. J. Garland
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 456

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Book Description
The aim of this book is to provide pharmacologists with an understandi ng of how events at the cellular level impact on the cardiovascular sy stem as a whole. The pharmacological principles and major techniques r elating to this area are poorly covered in the literature at present, and this volume will be the first to provide an accessible introductio n to the subject.

Author: Paul R. Gard
Publisher: CRC Press
ISBN: 1482267977
Category : Medical
Languages : en
Pages : 184

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Book Description
Pharmacology, in its own right, is a massive subject area and has been the focus of several major textbooks. Human Pharmacology is a readable, introductory text covering all of the main aspects of pharmacology in a way that enthuses the reader to study the subject further. Each chapter includes line drawings and figures to illustrate concepts and m

Author: Nicholas A. Mortillaro
Publisher: Elsevier
ISBN: 1483262081
Category : Science
Languages : en
Pages : 443

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Book Description
The Physiology and Pharmacology of the Microcirculation, Volume 2, discusses the microcirculatory function of specific organ systems. The first volume of The Physiology and Pharmacology of the Microcirculation presented some general aspects of microcirculatory function and then concentrated on the microcirculation of a specific organ system, namely, brain, eye, heart, and kidneys. This second and final volume continues the presentation of microcirculatory function of specific organ systems. The book begins with a chapter on the microcirculation of the lungs, with a description of its microcirculatory features and current methods of study. This is followed by separate chapters on the microcirculation of the splanchnic organs. These include the stomach, emphasizing hemodynamics, tissue oxygenation, and control of blood flow; the small and large intestine. Subsequent chapters deal with the microcirculatory responses of both the liver and spleen to different physiological and pharmacological challenges; the microcirculation of the skin, with emphasis on human microcirculation; normal and abnormal microcirculatory dynamics in skeletal muscle; microcirculation of bone; and microcirculation of the salivary glands and exocrine pancreas. The final chapter presents a selective review of pathological events involving the microcirculation, with the emphasis directed toward human diseases.