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Author: Sunil Jawla Publisher: LAP Lambert Academic Publishing ISBN: 9783659409059 Category : Languages : en Pages : 80
Book Description
Naproxen and ibuprofen (aryl propionic acid derivatives) both are classified as non-steroidal anti-inflammatory agents. Except HPLC, no sensitive methods were reported for both the drugs. HPLC methods suffer from two drawbacks- first; requirement of costly chemicals and second; more time consuming. Because atomic absorption spectroscopy (AAS) methods are simple, sensitive, rapid, reproducible and uses low cost chemicals. The objective of present research work was to develop highly sensitive and economical analytical methods for the quantitative estimation of naproxen and ibuprofen in pharmaceutical formulations by AAS. The methods were based on the reaction of naproxen and ibuprofen with copper and cobalt chloride to form coloured metal complexes. These complexes were extracted with organic solvents and digested with acids. Naproxen and ibuprofen were indirectly estimated by AAS via the determination of the copper and cobalt content in the formed complexes. The proposed methods may be used for routine analysis of pharmaceutical formulations containing aryl propionic acid derivatives and similar pharmaceutical drugs by the analytical chemist.
Author: Sunil Jawla Publisher: LAP Lambert Academic Publishing ISBN: 9783659409059 Category : Languages : en Pages : 80
Book Description
Naproxen and ibuprofen (aryl propionic acid derivatives) both are classified as non-steroidal anti-inflammatory agents. Except HPLC, no sensitive methods were reported for both the drugs. HPLC methods suffer from two drawbacks- first; requirement of costly chemicals and second; more time consuming. Because atomic absorption spectroscopy (AAS) methods are simple, sensitive, rapid, reproducible and uses low cost chemicals. The objective of present research work was to develop highly sensitive and economical analytical methods for the quantitative estimation of naproxen and ibuprofen in pharmaceutical formulations by AAS. The methods were based on the reaction of naproxen and ibuprofen with copper and cobalt chloride to form coloured metal complexes. These complexes were extracted with organic solvents and digested with acids. Naproxen and ibuprofen were indirectly estimated by AAS via the determination of the copper and cobalt content in the formed complexes. The proposed methods may be used for routine analysis of pharmaceutical formulations containing aryl propionic acid derivatives and similar pharmaceutical drugs by the analytical chemist.
Author: Muhammad Sajid Hamid Akash Publisher: Springer Nature ISBN: 9811515476 Category : Medical Languages : en Pages : 235
Book Description
Recent advances in the pharmaceutical sciences and biotechnology have facilitated the production, design, formulation and use of various types of pharmaceuticals and biopharmaceuticals. This book provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.
Author: Ashutosh Kar Publisher: New Age International ISBN: 9788122415827 Category : Medical Languages : en Pages : 558
Book Description
About the Book: During the past two decades, there have been magnificent and significant advances in both analytical instrumentation and computerized data handling devices across the globe. In this specific context the remarkable proliferation of windows
Author: Anette Müllertz Publisher: Springer ISBN: 1493940295 Category : Medical Languages : en Pages : 829
Book Description
The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.
Author: Lena Ohannesian Publisher: CRC Press ISBN: 0824741943 Category : Medical Languages : en Pages : 605
Book Description
Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.
Author: Bernhard Welz Publisher: John Wiley & Sons ISBN: 3527611681 Category : Science Languages : de Pages : 965
Book Description
The thoroughly revised new edition of this best-seller, presents the wide use of AAS in numerous fields of application. The comparison between the different AAS techniques enables the reader to find the best solution for his analytical problem. Authors Bernhard Welz and Michael Sperling have succeeded in finding a balance between theoretical fundamentals and practical applications. The new chapter 'physical fundamentals' describes the basic principles of AAS. The development of AAS is now described in a separate chapter. Further new chapters are devoted to the latest developments in the field of flow injection and the use of computers for laboratory automation. Methodological progress e. g. speciation analysis is also covered in this new edition. The index and the extensive bibliography make this book a unique source of information. It will prove useful not only for analytical chemists, out also spectroscopists in industry, institutes, and universities. Atomic Absorption Spectrometry will also be invaluable for clinics and research institutes in the fields of biochemistry, medicine, food technology, geology, metallurgy, petrochemistry, and mineralogy.
Author: Richard A. Storey Publisher: John Wiley & Sons ISBN: 1119970172 Category : Science Languages : en Pages : 557
Book Description
The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection
Author: David C. Lee Publisher: John Wiley & Sons ISBN: 9788126516827 Category : Languages : en Pages : 388
Book Description
This book concentrates on the analytical aspects of drug development and manufacture, focusing on the analysis of the active ingredient or drug substance. It provides those joining the industry or other areas of pharmaceutical research with a source of reference to a broad range of techniques and their applications, allowing them to choose the most appropriate analytical technique for a particular purpose.· Quality Control and Regulation· Development of Achiral Separation Methods in Pharmaceutical Analysis· Chiral Analysis of Pharmaceuticals· Nuclear Magnetic Resonance Spectroscopy in Pharmaceutical Analysis· Mass Spectrometry in Pharmaceutical Analysis· Vibrational Spectroscopy in Pharmaceutical Analysis· Solid-State Analysis and Polymorphism· Microscopy and Imaging in Pharmaceutical Analysis· Process Analysis in the Pharmaceutical Industry
Author: Sunil Jawla
Author: Sunil Jawla
Author: Muhammad Sajid Hamid Akash
Author: Ashutosh Kar
Author: Anette Müllertz
Author: Lena Ohannesian
Author: Irving Sunshine
Author: G. Vidya Sagar
Author: Bernhard Welz
Author: Richard A. Storey
Author: David C. Lee