Perturbations In Neuroimflammation-Related Pathways In Chronic Paclitaxel-Induced Peripheral Neuropathy (PIPN) In Breast Cancer Survivors PDF Download

Author: Kord Kober
Publisher:
ISBN:
Category :
Languages : en
Pages :

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The prevalence of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors is as high as 60%. CIPN is the most debilitating symptom reported oncology patients and can lead to treatment discontinuation. No interventions are available to treat CIPN. A critical barrier to the development of efficacious interventions is the lack of understanding of the mechanisms underlying CIPN. In this pilot study, we used a systems biology approach to evaluate the molecular characteristics associated with paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory (NI) mechanisms in pre-clinical studies. The objective of this pilot study was to compare gene expression patterns between breast cancer (BC) survivors with and without PIPN with a focus on neuroinflammatory-related processes.

Author: Kord Kober
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description
Introduction - The prevalence of chemotherapy-induced peripheral neuropathy (CIPN) in cancer survivors is as high as 60%. CIPN is the most debilitating symptom reported oncology patients and can lead to treatment discontinuation. No interventions are available to treat CIPN. A critical barrier to the development of efficacious interventions is the lack of understanding of the mechanisms underlying CIPN. In this pilot study, we evaluated the molecular characteristics associated with paclitaxel-induced peripheral neuropathy (PIPN).Objectives - Compare differential gene expression (GE) between breast cancer (BC) survivors with and without PIPN. Methods - GE in peripheral blood was assayed using RNA-seq. Differentially expressed (DE) genes and pathways were identified between survivors who received paclitaxel and did (n=25) and did not (n=25) develop PIPN.Results - BC survivors with PIPN were significantly older; more likely to be unemployed; reported lower alcohol use; had a higher BMI, and poorer functional status; and had a higher number of lower extremity sites with loss of light touch, cold, and pain sensations, and higher vibration thresholds. No between group differences were found in the total dose of paclitaxel received or in the percentage of patients who had a dose reduction or delay due to PIPN. We found 140 DE genes and 21 DE pathways (e.g., signaling (PI3K/AKT, mTOR), oxidative stress (p53 signaling), and mitochondrial impairment (Mitophagy - animals)).Conclusions - Chronic PIPN is associated with GE changes in peripheral blood. Our findings support previously hypothesized mechanisms of PIPN and suggest additional genes for validation and potential therapeutic targets.

Author: Maryam Lustberg
Publisher: Springer Nature
ISBN: 3030786633
Category : Medical
Languages : en
Pages : 265

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Book Description
This book comprehensively examines chemotherapy-induced peripheral neuropathy (CIPN), a common dose-limiting condition that negatively affects both the quality of life of cancer patients and disease outcomes. CIPN remains a challenging area for both clinical care and research, as there are multiple unresolved issues. Written by leading international experts, the book discusses the natural history of CIPN, the latest predictors of toxicity, instruments for evaluating symptoms, and prevention/therapeutic strategies, as well as patients’ experiences of this common clinical syndrome. Lastly it highlights avenues for future research to enhance our understanding of CIPN. Providing essential information on the management of CIPN and the latest research in the field, this book is a valuable resource for researchers and healthcare providers working with patients with various malignant diseases.

Author: Robert B. Raffa
Publisher: CRC Press
ISBN: 1439862192
Category : Health & Fitness
Languages : en
Pages : 225

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There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early

Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 194

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Author: Jerome Bickenbach
Publisher: Hogrefe & Huber Publishing
ISBN: 9780889374317
Category : Classification
Languages : en
Pages : 0

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ICF Research Branch in cooperation with the WHO Collaborating Centre for the Family of International Classifications in Germany (at DIMDI) Practical, standardized tools to assess and document functioning, disability, and health according to the WHO ICF in a variety of health conditions and settings The WHO's International Classification of Functioning, Disability and Health (ICF) is the accepted common framework for understanding and documenting functioning and disability. The ICF Core Sets selected for this book have now been developed to facilitate the standardized use of the ICF in real-life clinical practice and thus improve quality of care. By using this collection of clear checklists, definitions, and forms, clinicians will quickly and easily be able to assess clients with a range of typical health conditions at different stages and in a variety of health care contexts. This manual: * Introduces the concepts of functioning and disability * Describes how and why the ICF Core Sets have been developed * Shows, step-by-step, how to apply the ICF Core Sets in clinical practice * Includes all 31 ICF Core Sets plus documentation forms (more than 1,400 pages of printable PDFs) on a CD-ROM. This manual is inherently multi-professional and will be of benefit not only for practitioners working in various health care contexts but also for students and teachers.

Author: Linda S. Aglio
Publisher: Springer
ISBN: 3319501410
Category : Medical
Languages : en
Pages : 457

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Divided into twelve sections that cover the entirety of anesthetic practice, this is a case-based, comprehensive review of anesthesiology that covers the basics of anesthetic management and reflects all new guidelines and recently developed standards of care. Each chapter of Anesthesiology: Clinical Case Reviews begins with a specific clinical problem or a clinical case scenario, followed by concise discussions of preoperative assessment, intraoperative management, and postoperative pain management. In addition to residents and fellows, this book is written for practicing anesthesiologists, student nurse anesthetists, and certified registered nurse anesthetists (CRNAs).

Author: Nirmal Joshee
Publisher: Springer Nature
ISBN: 3030312690
Category : Science
Languages : en
Pages : 439

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Book Description
This book offers a fresh look on a variety of issues concerning herbal medicine - the methods of growing and harvesting various medicinal plants; their phytochemical content; medicinal usage; regulatory issues; and mechanism of action against myriad of human and animal ailments. ‘Medicinal Plants: From Farm to Pharmacy’ comprises chapters authored by renowned experts from academics and industry from all over the world. It provides timely, in-depth study/analysis of medicinal plants that are already available in the market as supplements or drug components, while also introducing several traditional herbs with potential medicinal applications from various regions of the world. The book caters to the needs of a diverse group of readers: plant growers, who are looking for ways to enhance the value of their crops by increasing phytochemical content of plant products; biomedical scientists who are studying newer applications for crude herbal extracts or isolated phytochemicals; clinicians and pharmacologists who are studying interactions of herbal compounds with conventional treatment modalities; entrepreneurs who are navigating ways to bring novel herbal supplements to the market; and finally, natural medicine enthusiasts and end-users who want to learn how herbal compounds are produced in nature, how do they work and how are they used in traditional or modern medicine for various disease indications.

Author: Azamal Husen
Publisher: Springer Nature
ISBN: 3030730778
Category : Science
Languages : en
Pages : 479

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Book Description
Forests cover thirty-one percent of the world’s land surface, provide habitats for animals, livelihoods for humans, and generate household income in rural areas of developing countries. They also supply other essential amenities, for instance, they filter water, control water runoff, protect soil erosion, regulate climate, store nutrients, and facilitate countless non-timber forest products (NTFPs). The main NTFPs comprise herbs, grasses, climbers, shrubs, and trees used for food, fodder, fuel, beverages, medicine, animals, birds and fish for food, fur, and feathers, as well as their products, like honey, lac, silk, and paper. At present, these products play an important role in the daily life and well-being of millions of people worldwide. Hence the forest and its products are very valuable and often NTFPs are considered as the ‘potential pillars of sustainable forestry’. NTFPs items like food, herbal drugs, forage, fuel-wood, fountain, fibre, bamboo, rattans, leaves, barks, resins, and gums have been continuously used and exploited by humans. Wild edible foods are rich in terms of vitamins, protein, fat, sugars, and minerals. Additionally, some NTFPs are used as important raw materials for pharmaceutical industries. Numerous industry-based NTFPs are now being exported in considerable quantities by developing countries. Accordingly, this sector facilitates employment opportunities in remote rural areas. So, these developments also highlight the role of NTFPs in poverty alleviation in different regions of the world. This book provides a wide spectrum of information on NTFPs, including important references. We hope that the compendium of chapters in this book will be very useful as a reference book for graduate and postgraduate students and researchers in various disciplines of forestry, botany, medical botany, economic botany, ecology, agroforestry, and biology. Additionally, this book should be useful for scientists, experts, and consultants associated with the forestry sector.

Author: Suresh I.S. Rattan
Publisher: Springer Science & Business Media
ISBN: 1402050585
Category : Medical
Languages : en
Pages : 365

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This book offers a broad-ranging assessment of current efforts of the molecular, cellular, hormonal, nutritional and lifestyle strategies being tested and applied by biogerontologists in the search for effective means of intervention, prevention and treatment of age-related diseases, and for achieving healthy old age. Employing a semi-academic style, the book presents data from experimental systems, while focusing primarily on their applications to humans in the prevention and treatment of age-related impairments.