Peripheral Neuropathy in Childhood PDF Download

Author: Robert A. Ouvrier
Publisher: Cambridge University Press
ISBN: 9781898683179
Category : Medical
Languages : en
Pages : 350

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Book Description
A liberally illustrated and fully updated new edition of this very practical text.

Author: Robert A. Ouvrier
Publisher:
ISBN: 9780608058733
Category :
Languages : en
Pages : 251

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Book Description

Author: Hugh J. McMillan
Publisher: Springer
ISBN: 3319613618
Category : Medical
Languages : en
Pages : 402

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Book Description
This book describes how to perform nerve conduction studies and electromyography in children, and explains the relevant physiology and anatomy crucial to making a diagnosis. Relevant case presentations are included to aid learning, and the authors also focus on the practical applications of the test results, including discussions of major neuromuscular diseases amenable to diagnosis via electromyography. Pediatric Electromyography: Concepts and Clinical Applications is aimed at residents, technologists and staff pediatric neurologists, as a practical guide and exam study guide.

Author: Deborah Lee
Publisher:
ISBN:
Category : Electronic dissertations
Languages : en
Pages : 216

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Book Description
The principal toxicity for children who receive vincristine for the treatment of acute lymphocytic leukemia (ALL) is peripheral neuropathy, with symptoms that negatively affect physical function and may require the reduction or withdrawal of chemotherapy; even though cumulative dosing has not been shown to increase peripheral neuropathy. This population not only has to deal with the physical challenges of cancer but also can have psychosocial and cognitive effects from treatment. Utilizing secondary analysis, the purpose of this dissertation is to examine peripheral neuropathy (PN) trajectory during the second year of ALL treatment which has not been investigated in children receiving vincristine. Describing these symptom patterns in children carries the potential to guide future targeted nursing interventions. The Symptom Management Model will conceptually guide this three-manuscript dissertation to describe the patients' experience and the development of PN over year two of treatment.Chapter 2 (manuscript 1) examined the state of the science relative to valid and reliable assessment tools for measuring VIPN in pediatric patients receiving chemotherapy through a review of the literature. The results of the scoping review identified two valid and reliable measures (i.e., Ped-mTNS, mTNS©-PV), with one tool better suited for children (mTNS©-PV).Chapter 3 (manuscript 2) and Chapter 4 (manuscript 3) involve a secondary analysis using data collected from an observational, longitudinal, prospective, multi-center study, entitled The Advance Trial, funded by the National Cancer Institute. Chapter 3 (manuscript 2) characterizes the changes in VIPN in a retrospective sample of 77 children with ALL using the cumulative score of the modified TNS©-PV (1-20; higher = more severe) monthly at 12, 15, 18, 21, and 24 months and identifies which nerve pathway contributes to a higher VIPN cumulative score using the subscales of the modified TNS©-PV at the aforementioned time points. These results provide evidence that VIPN is persistent during the second year of ALL treatment and that the sensory/motor pathway is affected the most.Utilizing the same aforementioned data set, Chapter 4 (manuscript 3) examines whether the patient characteristics and treatment characteristics (i.e., race, sex, age, VIPN at 12 months) are associated with VIPN severity at 24 months based on the modified TNS©-PV cumulative score. The modified TNSÓ-PV scores were not correlated with age, sex, race or VIPN at 12 months. Female sex and VIPN at 12 months are associated with VIPN at 24 months as an interaction. Early identification of patients at risk for severe VIPN will enable nurses to proactively screen and monitor patients for peripheral neuropathy as well as recommend interventions to improve this population's functional status.Results from this three-manuscript dissertation add to the growing body of evidence showing a high incidence of PN in children, specifically sensory/motor neuropathy, that does not resolve during the second year of ALL treatment. Proactive assessment and early interventions directed toward children at risk to improve their physical function should be investigated. Studies in larger samples are needed to validate these findings. Patient and provider education is vital to prevent injuries and other complications of PN as well as to improve a patient's quality of life and physical functioning. Future research should focus on examining the psychosocial and cognitive disabilities resulting from PN, examining differences in symptom presentation and functioning between boys and girls with PN, and finding more effective means of treatment.

Author: Barbro Westerberg
Publisher:
ISBN: 9789172225299
Category : Nerves, Peripheral
Languages : en
Pages : 141

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Author: Sanjay Saint
Publisher: Oxford University Press, USA
ISBN: 0190862807
Category : Medical
Languages : en
Pages : 609

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Preceded by: Clinical clerkship in inpatient medicine / Sanjay Saint. 3rd ed. c2010.

Author: National Academies of Sciences Engineering and Medicine
Publisher:
ISBN: 9780309683494
Category :
Languages : en
Pages :

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Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.

Author: Caroline E. Mohrmann
Publisher:
ISBN:
Category :
Languages : en
Pages : 130

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As the number of childhood cancer survivors (CCS) is increasing, it is imperative to understand the late-effects of childhood cancer therapy to optimize their health and quality of life. Chemotherapy-induced peripheral neuropathy (CIPN) is an unpleasant side effect of chemotherapy which impacts the peripheral nervous system and results in a variety of sensory and motor abnormalities such as numbness, pain, muscle weakness, or impaired coordination. While CIPN is poorly understood in general, there is a particularly poor understanding of the experience of CIPN among CCS, which leads to lack of appropriate support for maximizing physical function and quality of life. This qualitative study used narrative analysis with a phenomenological influence to understand the lived experience of CIPN among five CCS between the ages of 18 and 30. Semi-structured interviews and photo-elicitation were used. Photo-elicitation involves utilizing photographs to enhance the participant's expression of their experience. The lived experience of CIPN is characterized by "a condition of disconnection" with three subthemes : (1) disconnection between mind and body, (2) disconnection between anticipated potential and reality, and (3) disconnection between survivors and support. The condition of disconnection leads to a variety of negative physical and emotional performance outcomes that impact vocation, schooling, and other social roles important in the lives of adolescent and young adult CCS. These findings support the need for the development of interventions to 're-build the connections' CCS are lacking, as well as focused clinical assessments to identify this under-appreciated condition.

Author: Pierre Landrieu
Publisher: Elsevier Inc. Chapters
ISBN: 0128078804
Category : Medical
Languages : en
Pages : 66

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Book Description
Hereditary neuropathies (HN) with onset in childhood are categorized according to clinical presentation, pathogenic mechanism based on electrophysiology, genetic transmission and, in selected cases, pathological findings. Especially relevant to pediatrics are the items “secondary” versus “primary” neuropathy, “syndromic versus nonsyndromic,” and “period of life.” Different combinations of these parameters frequently point toward specific monogenic disorders. Ruling out a neuropathy secondary to a generalized metabolic disorder remains the first concern in pediatrics. As a rule, metabolic diseases include additional, orienting symptoms or signs, and their biochemical diagnosis is based on logical algorithms. Primary, motor sensory are the most frequent HN and are dominated by demyelinating autosomal dominant (AD) forms (CMT1). Other forms include demyelinating autosomal recessive (AR) forms, axonal AD/AR forms, and forms with “intermediate” electrophysiological phenotype. Peripheral motor neuron disorders are dominated by AR SMN-linked spinal muscular atrophies. (Distal) hereditary motor neuropathies represent 40 genes with various biological functions have been found to be responsible for primary HN. Many are responsible for various phenotypes, including some without the polyneuropathic trait, and some for various types of transmission.

Author: Julius Hoffman
Publisher:
ISBN:
Category : Children
Languages : en
Pages : 214

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