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Perioperative Inflammation as Triggering Origin of Metastasis Development

Perioperative Inflammation as Triggering Origin of Metastasis Development PDF Author: Michael W. Retsky
Publisher: Springer
ISBN: 3319579436
Category : Medical
Languages : en
Pages : 236

Book Description
The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses. With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.

Perioperative Inflammation as Triggering Origin of Metastasis Development

Perioperative Inflammation as Triggering Origin of Metastasis Development PDF Author: Michael W. Retsky
Publisher: Springer
ISBN: 3319579436
Category : Medical
Languages : en
Pages : 236

Book Description
The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses. With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.

Proceedings of 2nd Edition of International Conference on Clinical Oncology and Molecular Diagnostics 2018

Proceedings of 2nd Edition of International Conference on Clinical Oncology and Molecular Diagnostics 2018 PDF Author: EuroScicon
Publisher: EuroScicon
ISBN:
Category : Medical
Languages : en
Pages : 70

Book Description
June 11- 13, 2018 | Dublin, Ireland Key Topics : Oncology, Clinical Oncology, Radiation Oncology, Organ Specific Cancer, Cancer Metastasis, Hematology- Oncology, Breast Cancer, Skin Cancer, Cancer Biomarkers, Oncogenomics, Cancer Diagnosis And Screening, Cancer Biopsy, Chemotherapy, Molecular Diagnosis And Diagnostics, Cancer Drugs And Vaccines, Complementary And Alternative Medicine, Oncology Nursing And Care, Cancer Prevention: Mode Of Existence, Cancer Epidemiology, Cancer Epigenetics,

Selective Decontamination of the Digestive Tract (SDD)

Selective Decontamination of the Digestive Tract (SDD) PDF Author: Hans Rommes
Publisher: Springer Nature
ISBN: 3030652254
Category : Medical
Languages : en
Pages : 304

Book Description
This book explains the basic concepts of Selective Decontamination of the Digestive tract (SDD) to help those involved in treating critically ill patients to improve outcomes and the quality of care. SDD has led to major changes in our understanding, the treatment and prevention of infections in critically ill patients over the past 40 years. It is the most studied intervention in intensive care medicine and is the subject of 73 randomized controlled trials, including over 15000 patients and 15 meta-analyses. SDD reduces morbidity and mortality, is cost-effective and safe as SDD does not increase antimicrobial resistance. Correct application of the SDD strategy enables ICU teams to control infections – even in ICUs with endemic antibiotic resistant microorganisms such as methicillin resistant S. aureus (MRSA). Describing the concept and application of SDD, and presenting case studies and microbiological flow charts, this practical guide will appeal to intensivists, critical care practitioners, junior doctors, microbiologists and ICU-nurses as well as infection control specialists and pharmacists.

Anesthesia and Perioperative Care of the High-Risk Patient

Anesthesia and Perioperative Care of the High-Risk Patient PDF Author: Ian McConachie
Publisher: Cambridge University Press
ISBN: 1107690579
Category : Medical
Languages : en
Pages : 501

Book Description
A concise summary of perioperative management of high-risk surgical patients, bridging the gap between the operating theatre and ICU.

Diseases of the Abdomen and Pelvis 2018-2021

Diseases of the Abdomen and Pelvis 2018-2021 PDF Author: Juerg Hodler
Publisher: Springer
ISBN: 3319750194
Category : Medical
Languages : en
Pages : 262

Book Description
This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.

Encyclopedia of Cancer

Encyclopedia of Cancer PDF Author: Manfred Schwab
Publisher: Springer Science & Business Media
ISBN: 3540368477
Category : Medical
Languages : en
Pages : 3307

Book Description
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Regulation of Endothelial Barrier Function

Regulation of Endothelial Barrier Function PDF Author: Sarah Y. Yuan
Publisher: Biota Publishing
ISBN: 1615041214
Category : Medical
Languages : en
Pages : 160

Book Description
The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell–cell and cell–matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.

Surgical Inflammation

Surgical Inflammation PDF Author: Jaime Arias, Maria-Angeles Aller and Jose-Ignacio Arias
Publisher: Bentham Science Publishers
ISBN: 1608057852
Category : Medical
Languages : en
Pages : 361

Book Description
This monograph offers the reader an integrated point-of-view about the inflammatory response related to injury, infections and tumors. This integration is based on the hypothesis that the multiple pathophysiological mechanisms making up inflammation represent the re-expression of ontogenic mechanisms during early embryo development as well as the recapitulation of ancestral phylogenetic mechanisms. The relevance of the anti-inflammatory treatments is also highlighted with respect to polytraumatic patients, advances in stem cell research, embryology and the wound healing mechanism. Readers of this book will have the chance of gaining a unique perspective about of the pathophysiological mechanisms involved in the multiple inflammatory conditions. This integrative concept about inflammation can be applied in biological investigation, as well as in clinical research and translational medicine.

Geriatric Gastroenterology

Geriatric Gastroenterology PDF Author: C. S. Pitchumoni
Publisher: Springer Science & Business Media
ISBN: 1441916237
Category : Medical
Languages : en
Pages : 660

Book Description
As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.

Indwelling Neural Implants

Indwelling Neural Implants PDF Author: William M. Reichert
Publisher: CRC Press
ISBN: 1420009303
Category : Medical
Languages : en
Pages : 300

Book Description
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel