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Author: Yanyan Li Publisher: Springer ISBN: 1493910108 Category : Medical Languages : en Pages : 113
Book Description
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Author: Yanyan Li Publisher: Springer ISBN: 1493910108 Category : Medical Languages : en Pages : 113
Book Description
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Author: J. Throck Watson Publisher: John Wiley & Sons ISBN: 1118681584 Category : Science Languages : en Pages : 972
Book Description
Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry
Author: Kalyani Dhusia Publisher: Springer Nature ISBN: 3030530779 Category : Science Languages : en Pages : 220
Book Description
In the past few decades, it has been realized through research that fungal siderophores epitomize the uptake of iron as well as other essential elements like zinc, magnesium, copper, nickel and arsenic. Understanding the chemical structures of different fungal siderophores and the membrane receptors involved in uptake of mineral ions has opened new areas for research. In this edited volume, recent research is presented on fungal siderophores in one comprehensive volume to provide researchers a strong base for future research. Siderophores are the low molecular weight, high affinity iron-chelating compounds produced by bacteria and fungi. They are responsible for transporting iron across the cell membrane. Fungi produce a range of hydroxamate siderophores involved in the uptake of essential elements in almost all microorganisms and plants. In recent years, siderophores have been used in molecular imaging applications to visualize and understand cellular functions, which thus provide an opportunity to identify new drug targets. Therefore, knowledge of fungal siderophores has become vital in current research. Siderophores have received much attention in recent years because of their potential roles and applications in various research areas. Their significance in these applications is because siderophores have the ability to bind a variety of metals in addition to iron, and they have a wide range of chemical structures and specific properties. For instance, siderophores function as biocontrols, biosensors, and bioremediation and chelation agents, in addition to their important role in weathering soil minerals and enhancing plant growth. This book focuses on siderophores with the following significant points. It discusses leading, state-of-the-art research in all possible areas on fungal siderophores. The contributors are well-known and recognized authorities in the field of fungal siderophores. It discusses a projection of practical applications of fungal siderophores in various domains. This is the first book exclusively on fungal siderophores. In this comprehensive, edited volume, we show leading research on fungal siderophores and provide the most recent knowledge of researchers' work on siderophores. This book presents in-depth knowledge on siderophores to researchers working in areas of health sciences, microbiology, plant sciences, biotechnology, and bioinformatics.
Author: John Buckingham Publisher: CRC Press ISBN: 9780412604409 Category : Science Languages : en Pages : 638
Book Description
A dictionary of natural products. This fourth supplementary volume includes new and updated entries. It should be of interest to natural product chemists and bioscientists. Also available as a substructure searchable CD-ROM.
Author: Steven M. Colegate Publisher: CRC Press ISBN: 1420006886 Category : Medical Languages : en Pages : 622
Book Description
Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, and NMR-based structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products and novel bioassay development.
Author: Mikhail Soloviev Publisher: John Wiley & Sons ISBN: 0470196491 Category : Science Languages : en Pages : 432
Book Description
The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.
Author: American Chemical Society. Meeting Publisher: ISBN: Category : Gardening Languages : en Pages : 392
Book Description
1. Botanical quality initiatives at the office of dietary supplements, National institutes of health -- 2. Current trends and future prospects of traditional Chinese medicines in the 21st century -- 3. Bioactive polyphenols from foods and dietary supplements : challenges and opportunities -- 4. Instrumental analysis of popular botanical products in the U.S. market -- 5. Challenges in assessing bioactive botanical ingredients in functional beverages -- 6. Bioactive natural products from Chinese tropical marine plants and invertebrates -- 7. Curcumin : potential health benefits, molecular mechanism of action, and its anticancer properties in vitro and in vivo -- 8. Need for analytical methods and fingerprinting : total quality control of phytomedicine Echinacea -- 9. Bioassay-guided isolation, identification, and quantification of the estrogen-like constituent from PC SPES -- 10. Intraspecific variation in quality control parameters, polyphenol profile, and antioxidant activity in wild populations of Lippia multiflora from Ghana -- 11. Protein tyrosine phosphatases 1B inhibitors from traditional Chinese medicine -- 12. Thioglucosidase-catalyzed hydrolysis of the major glucosinolate of Maca (Lepidium meyenii) to benzyl isothiocyanate : mini-review and simple quantitativeHPLC method -- 13. Studies on chemical constituents of jiaogulan (gynostemma pentaphyllum) -- 14. Chemical components of noni (morinda citrifolia L.) root -- 15. Characterization of chemical components of Ixeris denticulata -- 16. Bioavailability, metabolism, and pharmacokinetics of glycosides in Chinese herbs -- 17. Moringa, a novel plant rich in antioxidants, bioavailable iron, and nutrients -- 18. Stability and transformation of bioactive polyphenolic components of herbs in physiological pH -- 19. Bioavailability and synergistic effects of tea catechins as antioxidants in the human diet -- 20. Targeting inflammation using Asian herbs -- 21. Induction of apoptosis by Ligusticum chuanxiong in HSC-T6 stellate cells -- 22. Effect of combined use of isothiocyanate and black tea extract on dental caries -- 23. Cytotoxic properties of leaf essential oil and components from indigenous cinnamon (cinnamomum osmophloeum Kaneh) -- 24. Effect of black tea theaflavins on 12-0-tetradecanoylphorbol-13-acetate-induced inflammation : expression of proinflammatory cytokines and arachidonic acid metabolism in mouse ear and colon carcinogenesis in min (apc+/- ) mice -- 25. Shea butter : chemistry, quality, and new market potentials.
Author: Patrice Dion Publisher: Springer Science & Business Media ISBN: 354074231X Category : Science Languages : en Pages : 374
Book Description
This volume provides a comprehensive coverage of the principal extreme soil ecosystems of natural and anthropogenic origin. Extreme soils oppose chemical or physical limits to colonization by most soil organisms and present the microbiologist with exciting opportunities. Described here are a range of fascinating environments from permafrost to Martian soils. The book includes chapters on basic research in addition to applications in biotechnology and bioremediation.
Author: Yanyan Li
Author: Yanyan Li
Author: J. Throck Watson
Author: Kalyani Dhusia
Author: Loïc Charpy
Author: John Buckingham
Author: Steven M. Colegate
Author: Katharina Fabricius
Author: Mikhail Soloviev
Author: American Chemical Society. Meeting
Author: Patrice Dion