Author: Mario Barbosa Publisher: Woodhead Publishing ISBN: 008100852X Category : Technology & Engineering Languages : en Pages : 390
Book Description
Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair highlights the various important considerations that go into biomaterial development, both in terms of fundamentals and applications. After covering a general introduction to protein and cell interactions with biomaterials, the book discusses proteins in biomaterials that mimic the extracellular matrix (ECM). The properties, fabrication and application of peptide biomaterials and protein-based biomaterials are discussed in addition to in vivo and in vitro studies. This book is a valuable resource for researchers, scientists and advanced students interested in biomaterials science, chemistry, molecular biology and nanotechnology. Presents an all-inclusive and authoritative coverage of the important role which protein and peptides play as biomaterials for tissue regeneration Explores protein and peptides from the fundamentals, to processing and applications Written by an international group of leading biomaterials researchers
Author: Anwar Sunna Publisher: Springer ISBN: 3319660950 Category : Science Languages : en Pages : 300
Book Description
Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.
Author: Sang Jin Lee Publisher: Academic Press ISBN: 012802500X Category : Medical Languages : en Pages : 460
Book Description
In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry
Author: Gina Policastro Publisher: ISBN: Category : Bones Languages : en Pages : 272
Book Description
Both naturally occurring and synthetic polymeric materials are currently under investigation for use as tissue engineering constructs for bone defect repair. While, naturally occurring proteins and polysaccharides provide the inherent biochemical signaling necessary for proper bone regeneration, these constructs often lack mechanical and chemical properties suitable for this application. On the contrary, synthetic polymers, such as poly-¿-caprolactone (PCL) and polypropylene fumarate (PPF), are advantageous because of their tunable mechanical, degradation and chemical properties. However, these polymers tend to degrade into acidic byproducts that cause chronic inflammation in vivo and overall failure of the implant. Independently, both naturally occurring and synthetic materials fail to meet all of the necessary requirements for osteogenic tissue engineering. More recently, research has focused its attention on the synthesis of polymeric materials functionalized with bioactive peptides to overcome the previously mentioned limitations. Poly(ester urea)s are a high modulus, non-toxic, amino acid-based class of polymers that has been thoroughly investigated by the Becker group. Both its tunable properties and ease of functionality, makes this polymer ideal for bone tissue engineering applications. Phenylalanine-based poly(ester urea)s (poly(PHE)) have been reported to have tensile moduli in a range comparable to healthy bone tissue (~7 GPa), as well as non-acidic degradation byproducts. Poly(PHE)s can be easily functionalized with bioactive peptides, such as osteogenic growth peptide (OGP) for enhancement of its osteoinductive potential. OGP[10-14] is the active subunit of the naturally occurring tetradecapeptide that is known to upregulate proliferation, differentiation and matrix mineralization of osteoblast cell lines. In this dissertation, both OGP-tethered and OGP-crosslinked poly(PHE) materials were synthesized using efficient `click' chemistry techniques. These materials were tested in vitro and in vivo to reveal the enhanced osteoinductive ability of poly(PHE) materials for tissue engineering applications. With just 1% tethered OGP incorporation into the poly(PHE) network, osteogenic lineage commitment of human mesenchymal stem cells (hMSCs) was enhanced at both 2 and 4 weeks. In vivo results confirmed the osteoinductive ability of OGP[10-14]-tethered poly(PHE). Crosslinking OGP[10-14] into the poly(PHE) network was intended to enhance mechanical and osteoinductive properties of the polymer construct, simultaneously. Results show that toughness of the polymeric constructs increased with OGP-crosslinking, however a decrease in tensile modulus was observed, possibly due to low crosslinking density. Early osteogenic differentiation of mouse preosteoblast cells (MC3T3-E1) was also enhanced on these constructs. Osseointegration of metallic implants is also a major cause for concern in the medical world. Titanium is one of the most widely used implants for bone repair, however, it is not uncommon for these implants to fail due to a lack of tissue-metal integration in vivo. Here, the surface functionalization of titanium oxide (TiO2) substrates with catechol-bearing dendritic OGP[10-14] modular peptides is reported. Functionalized OGP[10-14] modular peptides were synthesized and non-covalently bound to the surface of TiO2. Osteogenic differentiation of MC3T3-E1 cells was tested to result in enhanced expression of osteogenic genes compared to cells cultured without OGP-functionalization. Finally, to keep with the theme of enhancing osteogenesis for bone tissue engineering applications, several other well-known bioactive peptides were studied in this dissertation. Bone morphogenetic protein 2 (BMP-2) is a peptide fragment responsible for upregulation of osteogenic differentiation of multipotent cell lines via enhanced expression of bone specific genes. The Arg-Gly-Asp (RGD) amino acid sequence is the well-known adhesion peptide found in extracellular matrix proteins such as vinculin and fibronectin. RGD has been shown in many studies, to influence cell lineage commitment through the promotion of focal adhesion and cell spreading on a surface. Here, the concentration-dependent synergistic effect of BMP-2 and RGD was studied on 2D gradient substrates. In nature, peptides do not exist and act as a single entity, therefore this study reveals a glimpse at what the future holds for studying concentration effects of multiple bioactive factors simultaneously for enhanced bone tissue regeneration. Each of these studies reveals the importance of blending synthetic materials with naturally occurring peptides for optimal tissue engineering constructs. There is a clear need for polymeric constructs with both the mechanical and biological properties necessary for bone tissue engineering, and this dissertation provides a solid foundation for the future of bone regeneration biomaterials in the Becker group.
Author: Jeffrey O. Hollinger Publisher: CRC Press ISBN: 1135501912 Category : Medical Languages : en Pages : 500
Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Author: Brent Vernon Publisher: Elsevier ISBN: 0857091379 Category : Medical Languages : en Pages : 425
Book Description
Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians. Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems
Author: Zoe Diana Draelos Publisher: John Wiley & Sons ISBN: 1118655486 Category : Medical Languages : en Pages : 560
Book Description
Back for a new edition, Zoe Draelos' outstanding resource to cosmetic dermatology again provides a highly-illustrated, clinical guide to the full range of cosmetic skin treatments. Bringing together experts from research, industry, surgery and practice, it is structured in four distinct parts for easy navigation by the busy clinician: Basic Concepts - giving an overview of the physiology pertinent to cosmetic dermatology and the delivery systems by which treatments can take effect; Hygiene Products - evaluating cleansing and moisturising products; Adornment - looking at aesthetic techniques such as cosmetics, nail protheses and hair treatment; Antiaging - ie, injectables, resurfacing and skin contouring techniques, and the rapidly growing area of Cosmeceuticals. With over 300 high-quality images and key summary boxes throughout, this new edition incorporates the newest procedural innovations in this rapidly developing field. Perfect for all dermatologists, especially those specialising in cosmetic dermatology and whether hospital-based or in private practice, it provides the complete cosmetic regimen for your patients and will be an indispensable tool to consult over and over again.
Author: Mustafa O. Guler Publisher: Royal Society of Chemistry ISBN: 1839161159 Category : Science Languages : en Pages : 395
Book Description
Research and new tools in biomaterials development by using peptides are currently growing, as more functional and versatile building blocks are used to design a host of functional biomaterials via chemical modifications for health care applications. It is a field that is attracting researchers from across soft matter science, molecular engineering and biomaterials science. Covering the fundamental concepts of self-assembly, design and synthesis of peptides, this book will provide a solid introduction to the field for those interested in developing functional biomaterials by using peptide derivatives. The bioactive nature of the peptides and their physical properties are discussed in various applications in biomedicine. This book will help researchers and students working in biomaterials and biomedicine fields and help their understanding of modulating biological processes for disease diagnosis and treatments.
Author: Jennifer J. McManus Publisher: Humana ISBN: 9781493996803 Category : Science Languages : en Pages : 266
Book Description
This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.
Author: Kishor Kumar Sadasivuni Publisher: Elsevier ISBN: 0081009747 Category : Science Languages : en Pages : 546
Book Description
Biopolymer Composites in Electronics examines the current state-of-the-art in the electronic application based on biopolymer composites. Covering the synthesis, dispersion of fillers, characterization and fabrication of the composite materials, the book will help materials scientists and engineers address the challenges posed by the increased use of biopolymeric materials in electronic applications. The influence of preparation techniques on the generation of micro, meso, and nanoscale fillers, and the effect of filler size and dispersion on various biopolymers are discussed in detail. Applications covered include sensors, actuators, optics, fuel cells, photovoltaics, dielectrics, electromagnetic shielding, piezoelectrics, flexible displays, and microwave absorbers. In addition, characterization techniques are discussed and compared, enabling scientists and engineers to make the correct choice of technique. This book is a ‘one-stop’ reference for researchers, covering the entire state-of-the-art in biopolymer electronics. Written by a collection of expert worldwide contributors from industry, academia, government, and private research institutions, it is an outstanding reference for researchers in the field of biopolymer composites for advanced technologies. Enables researchers to keep up with the rapid development of biopolymer electronics, which offer light, flexible, and more cost-effective alternatives to conventional materials of solar cells, light-emitting diodes, and transistors Includes thorough coverage of the physics and chemistry behind biopolymer composites, helping readers to become rapidly acquainted with the fiel Provides in-depth information on the range of biopolymer applications in electronics, from printed flexible conductors and novel semiconductor components, to intelligent labels, large area displays, and solar panels
Author: Mario Barbosa
Author: Anwar Sunna
Author: Sang Jin Lee
Author: Gina Policastro
Author: Jeffrey O. Hollinger
Author: Brent Vernon
Author: Zoe Diana Draelos
Author: Mustafa O. Guler
Author: Jennifer J. McManus
Author: Kishor Kumar Sadasivuni