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Author: Publisher: Elsevier ISBN: 0443236682 Category : Science Languages : en Pages : 550
Book Description
Peptide Catalysts, including Catalytic Amyloids, Volume 697 in this esteemed series, highlights new advances in the field, with this new volume presenting interesting topics on Screening of oxidative behaviors in catalytic amyloid assemblies, Catalytic amyloids derived for natural proteins, AFM-IR studies of catalytic amyloids, MD structural studies of catalytic amyloids, Characterization of crystalline, amyloid-like amino acid assemblies, Computational modeling of supramolecular peptide assemblies, and Assembly and activity of short prion-inspired peptides. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Updated release includes the latest information on Peptide Catalysts, including Catalytic Amyloids
Author: Publisher: Elsevier ISBN: 0443236682 Category : Science Languages : en Pages : 550
Book Description
Peptide Catalysts, including Catalytic Amyloids, Volume 697 in this esteemed series, highlights new advances in the field, with this new volume presenting interesting topics on Screening of oxidative behaviors in catalytic amyloid assemblies, Catalytic amyloids derived for natural proteins, AFM-IR studies of catalytic amyloids, MD structural studies of catalytic amyloids, Characterization of crystalline, amyloid-like amino acid assemblies, Computational modeling of supramolecular peptide assemblies, and Assembly and activity of short prion-inspired peptides. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Methods in Enzymology series Updated release includes the latest information on Peptide Catalysts, including Catalytic Amyloids
Author: Katsunori Tanaka Publisher: John Wiley & Sons ISBN: 3527344322 Category : Science Languages : en Pages : 560
Book Description
Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.
Author: Sudhir Paul Publisher: Karger Medical and Scientific Publishers ISBN: 3805570996 Category : Medical Languages : en Pages : 172
Book Description
This volume addresses fundamental questions concerning the immunological genesis of the catalytic activity in antibodies, its relationship with classical antigen binding activity, and the biochemical mechanisms involved in catalysis. The contents reflect three main challenges in the field, i.e. to delineate the biological functions of catalytic antibodies in autoimmune disease; to isolate therapy-grade antibody catalysts with sufficient specificity and turnover to permit rapid removal of microbial and tumor antigens; and to develop immunogens that recruit immature catalyst-producing B cells into the clonal selection pathway and induce adaptive improvements of the catalytic function. Well-edited and up-to-date, this book reviews the current knowledge in the field and explores ways by which natural and engineered catalytic activities can be harnessed for medical applications. It should therefore be of special interest to immunologists, biochemists, biotechnologists, rheumatologists and pathologists.
Author: Yulia Tsifansky-Zarchin Publisher: ISBN: Category : Languages : en Pages : 126
Book Description
"The ability of enzymes to fold into unique structures drives their remarkable catalytic activity. Recently, a great effort is done in order to duplicate this high activity of natural enzymes by using simple molecules, for instance amphiphilic peptides, which can self-assemble into different structures in water, creating microenvironments that emulate the active site of enzymes. In addition, the controlled assembly of amphiphilic peptides governs their self-replicating propensity, as it promotes their own formation by self-recognition of building blocks, as was previously shown by our group. The addition of functional groups to the selfreplicating peptides may provide bi-functional systems, which will be able to selfreplicate and perform enhanced catalysis, benefiting one another (Figure 1). In this study, we have first used short dipeptides and further synthesized longer amphiphilic peptides that can readily self-assemble into elongated fibrils and catalyse hydrolysis of thioesters.. The supramolecular architectures formed by the selfassembly of the peptides was characterized using battery of techniques. The peptides were tested for the esterase-like activity using different substrates, and the difference between ester and thioester hydrolysis was tested. We observed that Fmoc-FH appears to catalyze the hydrolysis reaction of the thioester substrate better than the oxyester substrate. For control, we used molecules such as acetyl Histidine (aH) as a nonaggregating analogue. We found the the designed catalyst enhancing the catalysis as twice as fast than the control reaction. We were able to provide insights into the factors that dictate the efficiency of the catalytic reaction, and in particular to demonstrate the role of the self-assembly property upon the catalytic activity. We believe that this research will get us closer to the ability of assembling an autocatalytic-replication cycle that will carry out the both functions as well as benefiting each other. "-- abstract.
Author: Yohei Yokobayashi Publisher: ISBN: 9780493099156 Category : Biochemical templates Languages : en Pages : 254
Book Description
The key feature that differentiates animate chemistry from inanimate chemistry is believed to lie in its complexity, the ability of the animate chemical systems to reproduce, to dynamically adapt to changes in environment, and to undergo Darwinian evolution. This thesis approaches the problem of chemical complexity using self-replicating peptides as a tool to design and construct various nonlinear chemical networks that exhibit various interesting emergent properties. In Chapter 2, an environmentally regulated replicator that adapts to the change in salt concentration is described. Chapter 3 explores the molecular ecology of two peptides that exhibit host-parasite dynamics. In Chapter 4, a minimal autocatalytic set of two nonreplicating peptides that engage in reciprocal catalysis is investigated. Finally, Chapter 5 illustrates the templating effect exerted by higher order complex, or self-assembling ligase. These results should contribute to not only to our understanding of nonlinear chemical systems, but also our ability to design de novo functional molecules especially peptides and proteins.
Author: Cheng-Yong Su Publisher: ISBN: 9789811217791 Category : Science Languages : en Pages : 550
Book Description
The construction of catalysts by supramolecular forces has recently become a powerful tool and the role of noncovalent interactions can assist in designing new tools for the construction of effective and selective catalytic systems. It is unquestionably, vastly important to understand how different noncovalent interactions can be controlled or manipulated under appropriate reaction conditions. Supramolecular catalysts have had a tremendous impact on the syntheses of both chemical commodities and fine chemicals over the last 50 years, leading to the discovery of new reactions that were previously deemed impossible. This means that supramolecular chemistry plays a predominant role in accelerating or understanding chemical reactions.This book which addresses the above points is written by some of the leading contributors in this field and is intended for graduate students, researchers and academics working in supramolecular chemistry, organic chemistry, inorganic chemistry, and physical chemistry as well as researchers with an interest in the area of catalysis. The authors give examples illustrating the growth of the field, especially with special emphasis on new results published over the last decade. They also provide an explanation of fundamentals and topical research.
Author: Peter I. Dalko Publisher: John Wiley & Sons ISBN: 3527610952 Category : Science Languages : en Pages : 559
Book Description
In this reference leaders at the forefront of research provide an insight into one of the hottest topics in organic synthesis, focusing on the most important enantioselective reactions. Clearly structured, each entry begins with a concise introduction, including a mechanistic discussion of the reaction, followed by preparative guidelines for newcomers, such as carefully selected working procedures with critical notes for bench chemists, rules of thumb and tips and tricks.
Author: Ian W. Hamley Publisher: John Wiley & Sons ISBN: 1118681428 Category : Technology & Engineering Languages : en Pages : 304
Book Description
This book provides an introduction to this exciting and relativelynew subject with chapters covering natural and synthetic polymers,colloids, surfactants and liquid crystals highlighting the many andvaried applications of these materials. Written by an expert in thefield, this book will be an essential reference for people workingin both industry and academia and will aid in understanding of thisincreasingly popular topic. Contains a new chapter on biological soft matter Newly edited and updated chapters including updated coverageof recent aspects of polymer science. Contain problems at the end of each chapter to facilitateunderstanding
Author: Ved Srivastava Publisher: Royal Society of Chemistry ISBN: 1788014332 Category : Science Languages : en Pages : 572
Book Description
Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.
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Author: Daniel Raymond Coleman
Author: Katsunori Tanaka
Author: Sudhir Paul
Author: Yulia Tsifansky-Zarchin
Author: Yohei Yokobayashi
Author: Cheng-Yong Su
Author: Peter I. Dalko
Author: Ian W. Hamley
Author: Ved Srivastava