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Author: Chris Van Der Walle Publisher: Academic Press ISBN: 0123849365 Category : Science Languages : en Pages : 381
Book Description
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Author: Chris Van Der Walle Publisher: Academic Press ISBN: 0123849365 Category : Science Languages : en Pages : 381
Book Description
The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Author: Vincent Lee Publisher: CRC Press ISBN: 9780824778965 Category : Science Languages : en Pages : 916
Book Description
This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Author: Aakanchha Jain Publisher: Elsevier ISBN: 0443189269 Category : Science Languages : en Pages : 331
Book Description
Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding. Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran. Adopts an interdisciplinary approach across biochemistry, molecular biology, pharmaceutical sciences and drug delivery, and biotechnological perspectives Features accessible figures, tables and graphical abstracts across all chapters to support understanding Examines various polysaccharides of current interest and aspects affecting their absorption, metabolism, excretion and detection
Author: Kenneth L. Andus Publisher: Springer Science & Business Media ISBN: 1461528984 Category : Medical Languages : en Pages : 507
Book Description
In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Author: Randall J. Mrsny Publisher: CRC Press ISBN: 1420078070 Category : Medical Languages : en Pages : 288
Book Description
Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is
Author: Sara Bobone Publisher: Springer ISBN: 3319064347 Category : Science Languages : en Pages : 147
Book Description
In her thesis, Sara Bobone outlines spectroscopic studies of antimicrobial peptides (AMPs) which are promising lead compounds for drugs used to fight multidrug resistant bacteria. Bobone shows that AMPs interact with liposomes and she clarifies the structure of pores formed by one of these molecules. These results help us to understand how AMPs are selective for bacterial membranes and how their activity can be finely tuned by modifying their sequence. Findings which solve several conundrums debated in the literature for years. In addition, Bobone uses liposomes as nanotemplates for the photopolymerization of hydrogels - exploiting the self- assembly properties of phospholipids. Bobone was able to trap an enzyme using nanometeric particles, while still allowing its activity by the diffusion of substrates and products through the network of the polymer. The innovative nano devices described in this thesis could solve many of the hurdles still hampering the therapeutic application of protein-based drugs.
Author: Ajay K. Banga Publisher: CRC Press ISBN: 1466566078 Category : Medical Languages : en Pages : 396
Book Description
There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The c
Author: Lars Hovgaard Publisher: CRC Press ISBN: 1439853886 Category : Medical Languages : en Pages : 395
Book Description
The rapid advances in recombinant DNA technology and the increasing availability of peptides and proteins with therapeutic potential are a challenge for pharmaceutical scientists who have to formulate these compounds as drug products. Pharmaceutical Formulation Development of Peptides and Proteins, Second Edition discusses the development of therapeutic peptides and proteins, from the production of active compounds via basic pre-formulation and formulation to the registration of the final product. Providing integrated solutions, this book discusses: The synthesis of peptides and the biotechnological production of proteins through recombinant DNA technology The physicochemical characteristics and stability of peptides and proteins The formulation of proteins as suspensions, solutions, and (mostly freeze-dried) solids The opportunities and challenges of non-parenteral delivery of peptides and proteins Risk factors, specifically the development of an unwanted immune response A simulation approach to describe the fate of peptides and proteins upon administration to a biological system The documentation required to register a protein-based drug Scientists in the pharmaceutical industry and academia as well as postgraduate students in pharmaceutical science will find this a valuable resource.
Author: Chris Van Der Walle
Author: Chris Van Der Walle
Author: Vincent Lee
Author: Vincent Lee
Author: Aakanchha Jain
Author: Kenneth L. Andus
Author: 
Author: Randall J. Mrsny
Author: Sara Bobone
Author: Ajay K. Banga
Author: Lars Hovgaard