Pathophysiology and Pharmacology of Erythropoietin PDF Download

Author: Horst Pagel
Publisher: Springer Science & Business Media
ISBN: 3642770746
Category : Medical
Languages : en
Pages : 318

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Book Description
The book contains a series of about 40 articles reflecting the state-of-the-art of the topic "Pathophysiology and Pharmacology of Erythropoietin". Results from both basic research and clinical studies are described in detail. The papers show that the possible therapeutic spectrum of erythropoietin could be expanded considerably when compared with the present situation.

Author: Horst Pagel
Publisher: Springer
ISBN: 9783540547778
Category : Medical
Languages : en
Pages : 328

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Book Description
The book contains a series of about 40 articles reflecting the state-of-the-art of the topic "Pathophysiology and Pharmacology of Erythropoietin." Results from both basic research and clinical studies are described in detail. The papers show that the possible therapeutic spectrum of erythropoietin could be expanded considerably when compared with the present situation.

Author: International Lübeck Conference on the Pathophysiology and Pharmacology of Erythropoietin 3, 1994, Lübeck
Publisher:
ISBN:
Category :
Languages : en
Pages : 22

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Author: Wolfgang Jelkmann
Publisher: Springer Science & Business Media
ISBN: 364283745X
Category : Medical
Languages : en
Pages : 267

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Book Description
The book contains a series of up-to-date review articles on the physiology and pathophysiology of the control of the production of red cells by the hormone erythropoietin. In addition, the results are reported of initial clinical trials using recombinant human erythropoietin (rhuEpo) in the treatment of the anemia of renal failure. The introductory chapter briefly recalls the history of erythropoietin research. The following section on the chemistry and physiology covers details of the structure of the hormone, assay methods, the identification of renal and extrarenal sites of the production of erythropoietin by in situ hybridization and the hypoxic stimulation of its production. A special chapter is devoted to the regulation of erythropoiesis in the neonatal period. There follows a section on pathophysiology, which includes respiratory, renal and malignant diseases in humans. In the final section the pharmacology of rhuEpo is considered. The strategy of the cloning and in vitro expression of the erythropoietin gene is described. Four chapters summarize clinical observations of the effects of rhuEpo in the correction of the anemia of renal failure, including the rise in hematocrit, blood viscosity and possibly hypertension, and the increased physical work capacity of the patients. The monograph will prove useful not only to investigators working in the basic fields of physiology, pharmacology and endocrinology, but also to practising physicians, especially hematologists and nephrologists, who are interested in erythropoietin for diagnostic or therapeutic purposes.

Author: International Lübeck Conference on the Pathophysiology and Pharmacology of Erythropoietin and Other Hematopoietic Growth Factors 4, 1997, Lübeck
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ISBN:
Category :
Languages : en
Pages : 17

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Author: International Lübeck Conference on the Pathophysiology and Pharmacology of Erythropoietin and Other Hematopoietic Growth Factors 5, 2000, Lübeck
Publisher:
ISBN:
Category :
Languages : en
Pages : 19

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Author: Mohammad Resa Nowrousian
Publisher: Springer Science & Business Media
ISBN: 3709176581
Category : Medical
Languages : en
Pages : 524

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Anemia is a frequent complication of cancer and its treatment. A number of clinical studies shows that the impact of anemia is much greater than previously thought. Beyond clinical symptoms, anemia significantly impairs physical and metabolic functions as well as patients' activity, well-being and quality of life. Life expectancy is also affected. In this book, written by a group of outstanding international experts, the current knowledge on anemia in cancer and its treatment with rhEPO is presented. Future developments are also discussed. Based on a broad spectrum of topics, the book describes the scientific and clinical aspects of anemia in various fields of oncology and gives diagnostic and therapeutic recommendations on when and how to use rhEPO.

Author:
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ISBN:
Category :
Languages : en
Pages :

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Author:
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ISBN:
Category :
Languages : en
Pages :

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Author: Henry Cohen
Publisher: McGraw Hill Professional
ISBN: 0071832769
Category : Medical
Languages : en
Pages : 300

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Book Description
A STEP-BY-STEP APPROACH TO DESIGNING ACCURATE DOSING REGIMENS Casebook in Pharmacokinetics and Drug Dosing uses real-life cases to teach pharmacy students, pharmacists, and clinical pharmacists how to apply pharmacokinetics to formulate proper dosing regimens. In order to be as clinically relevant as possible, the book not only discusses drugs with readily available therapeutic serum levels, but places equal emphasis on high-alert agents with narrow therapeutic indexes. Each drug chapter is written by clinical pharmacists who have hands-on experience in drug dosing and includes an overview of the drug’s pharmacology, including: Indications Mec hanisms of action Toxicities Pharmacokinetics There is comprehensive review and discussion of each drug's bioavailability, volume of distribution, clearance, half-life, therapeutic drug level monitoring, drug interactions, dosing, and availability. Each chapter is enhanced by numerous patient cases with clear step-by-step answers and explanations. Calculations, equations, and dosing recommendations are provided for each case.