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Author: Kenneth I. Berns Publisher: Springer Science & Business Media ISBN: 146848012X Category : Medical Languages : en Pages : 419
Book Description
The Parvoviridae have been of increasing interest to reseachers in the past decade. Their small size and simple structure have made them ame nable to detailed physiochemical analysis, and from this work relatively detailed information has resulted that has signficantly increased our un derstanding of the biology of these viruses. It has become clear that the Parvoviridae are of interest not only for their own sake, but also because their relative simplicity renders them useful probes in the study of the biology of host cells and of other DNA viruses with which they interact. The Dependovirus genus, for instance, contains the defective adeno-as sociated viruses (AA V), which require a coinfection with either an ad enovirus or a herpesvirus for productive multiplication. Studies of AA V, therefore, necessarily impinge on our understanding of the control of macromolecular synthesis by the helper virus. Similarly AA V has been reported to inhibit the oncogenicity of both adeno-and herpesviruses and has been used as a probe of mechanism in these instances as well. Finally, AA V establishes latent infections in vivo and is the only mammalian DNA virus where a comparable model system has been established in cell culture. This system has allowed study of the mechanism of latent infection at the molecular level."
Author: Kenneth I. Berns Publisher: Springer Science & Business Media ISBN: 146848012X Category : Medical Languages : en Pages : 419
Book Description
The Parvoviridae have been of increasing interest to reseachers in the past decade. Their small size and simple structure have made them ame nable to detailed physiochemical analysis, and from this work relatively detailed information has resulted that has signficantly increased our un derstanding of the biology of these viruses. It has become clear that the Parvoviridae are of interest not only for their own sake, but also because their relative simplicity renders them useful probes in the study of the biology of host cells and of other DNA viruses with which they interact. The Dependovirus genus, for instance, contains the defective adeno-as sociated viruses (AA V), which require a coinfection with either an ad enovirus or a herpesvirus for productive multiplication. Studies of AA V, therefore, necessarily impinge on our understanding of the control of macromolecular synthesis by the helper virus. Similarly AA V has been reported to inhibit the oncogenicity of both adeno-and herpesviruses and has been used as a probe of mechanism in these instances as well. Finally, AA V establishes latent infections in vivo and is the only mammalian DNA virus where a comparable model system has been established in cell culture. This system has allowed study of the mechanism of latent infection at the molecular level."
Author: Giorgio Gallinella Publisher: MDPI ISBN: 3039283103 Category : Medical Languages : en Pages : 342
Book Description
Viruses in the Parvoviridae family constitute one of the most diverse and intriguing fields of research. While they all share an ssDNA genome and a small capsid, they can differ widely in structure, genome organization and expression, virus–cell interaction, and impact on the host. Exploring such diversity and unraveling the inherent complexity in these apparently simple viruses is an ongoing endeavor and commitment for the scientific community. The translational implications of research on parvoviruses are relevant. Within the family, some viruses are important human and veterinary pathogens, in need of diagnostic methods and antiviral strategies; other viruses have long been studied and engineered as tools for oncolytic therapy, or as sophisticated gene delivery vectors, and can now display their wide and expanding applicative potential. This Special Issue of Viruses collects recent contributions in the field of parvovirus research, with a focus on new insights and research on unresolved issues, as well as new approaches exploiting systemic methodologies. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, and viral oncotherapy are a selection of the topics addressed in the issue that can be of relevance to the community involved in parvovirus research and of interest to a wider audience.
Author: J. R. Pattison Publisher: CRC Press ISBN: 1351092308 Category : Science Languages : en Pages : 271
Book Description
This book gives details of the discovery and research work on B19 virus to date. The virus is an autonomous parvovirus and many of its properties and much of its behaviour can be predicted from this. Accordingly, the detailed account of B19 viruses is set in the context of two general chapters on the nature of parvoviruses and the patterns of disease in animals produced by parvoviruses.
Author: Christopher J. Burrell Publisher: Academic Press ISBN: 0123751578 Category : Science Languages : en Pages : 605
Book Description
Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. - Features updated and expanded coverage of pathogenesis and immunity - Contains the latest laboratory diagnostic methods - Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control
Author: Frederick S.B. Kibenge Publisher: Elsevier ISBN: 0323910718 Category : Technology & Engineering Languages : en Pages : 745
Book Description
Aquaculture Virology, Second Edition covers all the known virus families, and specific diseases that affect each aquatic organism. Descriptions of each disease includes disease name, structure and composition of virus, classification and virus replication, epidemiology, pathology and immunity, diagnostic methods (gross pathology, histopathology, cell culture, PCR, sequencing, ELISA, etc.) and prevention and control. This is an excellent reference of updated foundational and practical knowledge from experts in both academia and research.Those interested in fish viral diseases will find the book an excellent source for high quality illustrations of viral structure, diagrams of pathogenesis of diseases, and many images of gross pathology and histopathology lesions, using the same format in all chapters to facilitate the reading and studying. This second edition of the book will cover all virus families and the specific diseases relevant to aquaculture with current information delivered in a systematic and succinct way to the researcher, teacher, student, diagnostic laboratory staff, clinical veterinarian, aquaculture disease practitioner, farmer, and all people that are interested in viruses in general. - Provides unique, comprehensive information on animal pathogens and viruses found in aquaculture and fisheries - Presents high-quality illustrations of viral structure, diagrams of viral disease processes, gross pathology, and histopathology lesions to aid in understanding - Incorporates all updated changes in taxonomy since the first edition - Includes a new chapter on the impact of climate change on the manifestations of different aquatic animal viral diseases - Describes aquatic viruses of the major aquatic animals, fish, crustaceans, and mollusks
Author: Mei-Hwei Chang Publisher: Springer ISBN: 981130050X Category : Medical Languages : en Pages : 229
Book Description
This book is aimed to emphasize the rationale and importance of prevention and management of viral hepatitis in children, providing cutting edge knowledge. Viral hepatitis is a major health problem in the world. Although most complications of viral hepatitis are observed in adults, primary infection with hepatitis viruses often occurs during infancy or childhood. To better control viral hepatitis, prevention and therapy if possible should be started in childhood. This book offers updated and unique information about viral hepatitis in children, which has vitally important impact on global disease outcome and control, yet not discussed as frequently as viral hepatitis in adults in previous medical literature. Better prevention and management strategies are covered, starting from infancy and childhood, and even earlier during fetal life. It will be very helpful for better control of viral hepatitis both for daily practice and for developing future strategies and directions. If we can successfully control viral hepatitis in children, there will be very little remaining chronic hepatitis and related complications such as liver cirrhosis or hepatoma in adults. We hope readers, including medical students, researchers, pediatricians, family medicine physicians, infectious disease personnel, public health workers, gastroenterologists, hepatologists and parents of children with chronic hepatitis, will be benefited by reading this book.
Author: Jane E. Sykes Publisher: Elsevier Health Sciences ISBN: 0323241948 Category : Medical Languages : en Pages : 933
Book Description
Canine and Feline Infectious Diseases is a practical, up-to-date resource covering the most important and cutting-edge advances in the field. Presented by a seasoned educator in a concise, highly visual format, this innovative guide keeps you current with the latest advances in this ever-changing field. 80 case studies illustrate the clinical relevance of the major infectious disease chapters. - Well-organized Major Infectious Diseases chapters break down content by etiologic agent and epidemiology, clinical signs and their pathophysiology, physical examination findings, diagnosis, treatment and prognosis, immunity, prevention, and public health implications. - Over 80 case studies illustrate how the information provided can be applied in everyday practice. - Logical approach to laboratory diagnosis guides you through all the steps needed to accurately diagnose and treat viral, bacterial, fungal, protozoal, and algal diseases. - Practical protocols provided by expert clinicians guide you in the management of canine and feline patients suspected to have infectious diseases, including handling, disinfection, isolation, and vaccination protocols. - Over 500 full color images – geographic distribution maps, life cycle drawings, and hundreds of color photographs – visually illustrate and clarify complex issues. - Easy-to-understand tables and boxes make content quickly accessible, eliminating the need to sort through dense text for critical information in the clinical setting.
Author: Joerg Bluemel Publisher: Academic Press ISBN: 012417146X Category : Medical Languages : en Pages : 716
Book Description
The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
Author: Allan Granoff Publisher: Academic Press ISBN: Category : Medical Languages : en Pages : 926
Book Description
Reference source of current virological knowledge. It is also the first to bring together all aspects of the subject for a wide variety of readers. Unique in its use of concise 'mini-review' articles, the mate rial covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria, and insects. More general articles focus on the effects of viruses on the immune system, the role of viruses in disease, oncology, gene therapy, and evolution, plus a wide range of related topics.
Author: Erik Lycke Publisher: Butterworth-Heinemann ISBN: 148319194X Category : Medical Languages : en Pages : 384
Book Description
Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.
Author: Kenneth I. Berns
Author: Kenneth I. Berns
Author: Giorgio Gallinella
Author: J. R. Pattison
Author: Christopher J. Burrell
Author: Frederick S.B. Kibenge
Author: Mei-Hwei Chang
Author: Jane E. Sykes
Author: Joerg Bluemel
Author: Allan Granoff
Author: Erik Lycke