Particulate Interactions in Dry Powder Formulation for Inhalation PDF Download

Author: Xian Ming Zeng
Publisher: CRC Press
ISBN: 1135729778
Category : Medical
Languages : en
Pages : 264

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Book Description
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles established in surface and colloidal chemistry with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. It review some of the studies carried out in dry powder formulation development, and proposes possible strategies in improving DPI efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).

Author: Hans Bisgaard
Publisher: CRC Press
ISBN: 0824741978
Category : Medical
Languages : en
Pages : 536

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Book Description
This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice. Examines the behavior of inspired spherical particles in the respiratory tract!Featuring over 1300 references, drawings, tables, and photographs.

Author: Xian Ming Zeng
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Book Description

Author: Inamuddin
Publisher: John Wiley & Sons
ISBN: 1119654998
Category : Technology & Engineering
Languages : en
Pages : 480

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Book Description
The explores the cutting-edge technology of polymer coatings. It discusses fundamentals, fabrication strategies, characterization techniques, and allied applications in fields such as corrosion, food, pharmaceutical, biomedical systems and electronics. It also discusses a few new innovative self-healing, antimicrobial and superhydrophobic polymer coatings. Current industrial applications and possible potential activities are also discussed.

Author: Harry G. Brittain
Publisher: CRC Press
ISBN: 9780824793722
Category : Medical
Languages : en
Pages : 440

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Book Description
This unique reference provides the first systematic coverage available in a single-source volume on the application of materials science techniques to the pharmaceutical field-offering a comprehensive program for the physical characterization of raw materials, drug substances, and formulated products.

Author: Teerapol Srichana
Publisher:
ISBN: 9781536106411
Category : Inhalers
Languages : en
Pages : 0

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Book Description
This book is a compilation of most works published during 2000-2016 in the area of dry powder inhalers, especially related to the issues with formulation and device design. The dry powder inhalers aim to deliver the medication to the respiratory airways. It is suitable for postgraduate students and researchers who work in the areas of dry powder inhalers. It provides some background knowledge in size characterization, flow properties, forces, and interaction of air and particles. It also ends with in vitro quality control of dry powder inhalers. This book was finished in Hawaii where the author spent his time during April 2016. Thank you to Prince of Songkla University for the financial support. The author had to work very hard for one month without a holiday. Thank you to Professor Aran Pattanothai for overseeing this work to make sure that the researchers were on schedule all the time. Thanks to the authors staff at the Graduate School, Prince of Songkla University who had to work hard and be patient when the author was not in the office. Thanks to the authors wife and son who had to wait for him at home in Thailand. Thanks to Dr Tan Suwandecha and Dr Janwit Dechraksa for their great efforts in copy editing and compiling all the references. The author also thanks Dr Somchai Sawatdee and Dr Dhamodharan Bakkiyaraj for their comments, and Dr Padmavathi Alwar Ramanujam for her proofreading. The greatest help was from Professor Alan Coombes, Professor Pornanong Aramwit, and Dr Brian Hodgeson for their criticisms and comments to make this book readable.

Author: Philip Chi Lip Kwok
Publisher: CRC Press
ISBN: 131531195X
Category : Medical
Languages : en
Pages : 201

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Book Description
The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

Author: Bret Berner
Publisher: John Wiley & Sons
ISBN: 1119772737
Category : Medical
Languages : en
Pages : 466

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Book Description
Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.

Author: Arthur H. Lefebvre
Publisher: CRC Press
ISBN: 1498736262
Category : Technology & Engineering
Languages : en
Pages : 284

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Book Description
The second edition of this long-time bestseller provides a framework for designing and understanding sprays for a wide array of engineering applications. The text contains correlations and design tools that can be easily understood and used in relating the design of atomizers to the resulting spray behavior. Written to be accessible to readers with a modest technical background, the emphasis is on application rather than in-depth theory. Numerous examples are provided to serve as starting points for using the information in the book. Overall, this is a thoroughly updated edition that still retains the practical focus and readability of the original work by Arthur Lefebvre.

Author: Ali Nokhodchi
Publisher: John Wiley & Sons
ISBN: 1118799542
Category : Science
Languages : en
Pages : 392

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Book Description
Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.