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Author: Robert J McCunney Publisher: CRC Press ISBN: 9781560325437 Category : Medical Languages : en Pages : 314
Book Description
Recent inhalation toxicology studies suggest that when laboratory rats are exposed to inorganic particles to the point that lung overload occurs, both benign and malignant tumours may develop. The significance of these results for estimating human risk, however, is unclear.; Originally published as a special issue of the journal "Inhalation Toxicology", the contributions to this volume are derived from a symposium held in March, 1995, by the Environmental Medical Service of the Massachusetts Institute of Technology. Topics addressed include epidemiology, the pathology of lung tumours, maximum tolerated doses in inhalation toxicology studies, risk assessment, the extrapolation of results from animal studies to humans, current modelling techniques and regulatory concerns.
Author: Robert J McCunney Publisher: CRC Press ISBN: 9781560325437 Category : Medical Languages : en Pages : 314
Book Description
Recent inhalation toxicology studies suggest that when laboratory rats are exposed to inorganic particles to the point that lung overload occurs, both benign and malignant tumours may develop. The significance of these results for estimating human risk, however, is unclear.; Originally published as a special issue of the journal "Inhalation Toxicology", the contributions to this volume are derived from a symposium held in March, 1995, by the Environmental Medical Service of the Massachusetts Institute of Technology. Topics addressed include epidemiology, the pathology of lung tumours, maximum tolerated doses in inhalation toxicology studies, risk assessment, the extrapolation of results from animal studies to humans, current modelling techniques and regulatory concerns.
Author: Ken Donaldson Publisher: CRC Press ISBN: 1420003143 Category : Medical Languages : en Pages : 462
Book Description
Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to transl
Author: United States. Public Health Service. Office of the Surgeon General Publisher: ISBN: Category : Government publications Languages : en Pages : 728
Book Description
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author: Bengt Fadeel Publisher: Academic Press ISBN: 0123869404 Category : Medical Languages : en Pages : 367
Book Description
An essential reference that discusses occupational exposure and the adverse health effects of engineered nanomaterials and highlights current and future biomedical applications of these nanomaterials in relation to nanosafety.
Author: Bryan Corrin Publisher: Elsevier Health Sciences ISBN: 0702046221 Category : Medical Languages : en Pages : 785
Book Description
With an emphasis on practical diagnostic problem solving, Pathology of the Lungs, 3rd Edition provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations.Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout.Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world’s recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required. Extensive use of summary tables, charts and graphs throughout the text. Helps simplify and clarify complex concepts and facilitates “at a glance comparisons between entities. Extensive reference list highlights landmark articles as well as including most up-to-date citations. Directs the trainee and practitioner to the most recent and authoritative sources for further reading and investigation
Author: Robert McCunney Publisher: Frontiers Media SA ISBN: 2832510965 Category : Medical Languages : en Pages : 209
Book Description
Particles and Health is an international conference taking place in October 2021 addressing issues in science and regulation. Regulatory initiatives in the European Union (EU) have suggested uniform hazard classifications for all poorly soluble low toxicity particles (PSLTs). Examples of PSLTs include carbon black, titanium dioxide and iron oxide, among others. Approaches have also been proposed for setting workplace exposure limits for PSLTs such as those of the German MAK Commission. The conference will include specific sections over a two day period of about 25 presentations, associated with PSLTs regarding the following major topics: (1) human studies, (2) animal inhalation studies associated with lung cancer,(3) animal and human studies associated with non pulmonary impacts, including reproductive, genetic and cardiac effects, and (4) regulatory application of scientific studies. This conference will include presentations regarding: Definition of PSLT’s with attention to both similarities and differences among these substances. • Address scientific studies regarding human health effects of PSLTs. The value of human studies over animal studies-when human-exposed populations can be studied adequately- will be emphasized. • Address translational toxicology challenges, including the appropriateness of rats as models for human lung pathogenesis (particularly lung cancer) in light of lung overload phenomena and species differences. • Serve as a platform to present current scientific information about PSLTs important for regulatory action. • Publication of pertinent conference presentations in the peer reviewed scientific literature will allow the presentations to live beyond the conference and subsequently be reviewed part of regulatory deliberations. • Establish an interdisciplinary setting for industry, academia and regulatory professionals to interact on an important topic. Such interaction can facilitate enhanced understanding of the science and ideally, more appropriate regulations, appropriate classification and labeling as well as for setting exposure limits, among others. • Recommend areas for further clarifying research regarding the significance of the rat as a model for translation toxicology. The goal of this conference is to present current scientific evidence regarding the numerous dimensions of particles and health and to facilitate interaction and discussions among attendees with expertise in toxicology, epidemiology, occupational and pulmonary medicine and exposure assessment. Interactions between these disciplines will aid in the sound and evidence-based scientific underpinning of regulatory considerations regarding PSLTs. Although regulatory concern regarding PSLTs has focused on lung cancer risk as a result of rat inhalation overload studies, this conference will address all relevant health end points, including genetic and reproductive issues as well, consistent with ECHA guidelines. Sample of Topics related to substances that may be characterized as PSLTs, including carbon black, coal, titanium dioxide, cerium oxide, aluminum oxide barium sulfate and iron oxide, among others. • Defining PSLTs • Epidemiological studies of PSLTs • Inhalation studies evaluating human cellular response to particles • Basic research studies on inflammatory to malignancy pathways • Animal studies, PLSTs and human risk: “New Insights into old data.” • New studies on PSLTs; 2 year carcinogenicity assays • Animal studies and gender specific responses to PSLTs. How does the USA National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) address this challenge of extrapolating rodent data to human risk assessment? • Role of the rodent model in human risk assessment of PSLTs and lung cancer risk • Adverse Outcome Pathways (AOPs) and Modes of Action (MOA): identification and recommendations for closing gaps in knowledge for rodents and humans. • Are there lessons to be learned from how the pharmaceutical industry’s approach to translational science (safety and efficacy) as evolved in recent years? • Setting exposure limits for PSLTs and Translational Toxicology. • Genotoxicity and Reproductive toxicity studies of PSLTs.
Author: Hans Marquardt Publisher: Academic Press ISBN: 0080543111 Category : Medical Languages : en Pages : 1355
Book Description
Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments.Key Features* Comprehensive text, covering all aspects of the field of toxicology* Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects* Identifies the various classes of chemical compounds responsible for the toxic effects* Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention* Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on National Security Publisher: ISBN: Category : United States Languages : en Pages : 1008
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on National Security Publisher: ISBN: Category : United States Languages : en Pages : 1016
Author: Robert J McCunney
Author: Robert J McCunney
Author: Ken Donaldson
Author: United States. Public Health Service. Office of the Surgeon General
Author: Bengt Fadeel
Author: Bryan Corrin
Author: Robert McCunney
Author: Hans Marquardt
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on National Security
Author: 
Author: United States. Congress. House. Committee on Appropriations. Subcommittee on National Security