Encyclopedia of Bioinformatics and Computational Biology PDF Download

Author:
Publisher: Elsevier
ISBN: 0128114320
Category : Medical
Languages : en
Pages : 3421

View

Book Description
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases

Author: Heinz Koeppl
Publisher: Springer Science & Business Media
ISBN: 1441967664
Category : Technology & Engineering
Languages : en
Pages : 407

View

Book Description
The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology.

Author: Frank Schweitzer
Publisher: Springer
ISBN: 3540738452
Category : Computers
Languages : en
Pages : 427

View

Book Description
This book lays out a vision for a coherent framework for understanding complex systems. By developing the genuine idea of Brownian agents, the author combines concepts from informatics, such as multiagent systems, with approaches of statistical many-particle physics. It demonstrates that Brownian agent models can be successfully applied in many different contexts, ranging from physicochemical pattern formation to swarming in biological systems.

Author: Andreas Deutsch
Publisher: Springer Science & Business Media
ISBN: 0817644156
Category : Science
Languages : en
Pages : 331

View

Book Description
This book focuses on a challenging application field of cellular automata: pattern formation in biological systems, such as the growth of microorganisms, dynamics of cellular tissue and tumors, and formation of pigment cell patterns. These phenomena, resulting from complex cellular interactions, cannot be deduced solely from experimental analysis, but can be more easily examined using mathematical models, in particular, cellular automaton models. While there are various books treating cellular automaton modeling, this interdisciplinary work is the first one covering biological applications. The book is aimed at researchers, practitioners, and students in applied mathematics, mathematical biology, computational physics, bioengineering, and computer science interested in a cellular automaton approach to biological modeling.

Author: Russell Schwartz
Publisher: MIT Press
ISBN: 0262303396
Category : Science
Languages : en
Pages : 403

View

Book Description
A practice-oriented survey of techniques for computational modeling and simulation suitable for a broad range of biological problems. There are many excellent computational biology resources now available for learning about methods that have been developed to address specific biological systems, but comparatively little attention has been paid to training aspiring computational biologists to handle new and unanticipated problems. This text is intended to fill that gap by teaching students how to reason about developing formal mathematical models of biological systems that are amenable to computational analysis. It collects in one place a selection of broadly useful models, algorithms, and theoretical analysis tools normally found scattered among many other disciplines. It thereby gives the aspiring student a bag of tricks that will serve him or her well in modeling problems drawn from numerous subfields of biology. These techniques are taught from the perspective of what the practitioner needs to know to use them effectively, supplemented with references for further reading on more advanced use of each method covered. The text, which grew out of a class taught at Carnegie Mellon University, covers models for optimization, simulation and sampling, and parameter tuning. These topics provide a general framework for learning how to formulate mathematical models of biological systems, what techniques are available to work with these models, and how to fit the models to particular systems. Their application is illustrated by many examples drawn from a variety of biological disciplines and several extended case studies that show how the methods described have been applied to real problems in biology.

Author: Radek Erban
Publisher: Cambridge University Press
ISBN: 1108572995
Category : Mathematics
Languages : en
Pages : 322

View

Book Description
This practical introduction to stochastic reaction-diffusion modelling is based on courses taught at the University of Oxford. The authors discuss the essence of mathematical methods which appear (under different names) in a number of interdisciplinary scientific fields bridging mathematics and computations with biology and chemistry. The book can be used both for self-study and as a supporting text for advanced undergraduate or beginning graduate-level courses in applied mathematics. New mathematical approaches are explained using simple examples of biological models, which range in size from simulations of small biomolecules to groups of animals. The book starts with stochastic modelling of chemical reactions, introducing stochastic simulation algorithms and mathematical methods for analysis of stochastic models. Different stochastic spatio-temporal models are then studied, including models of diffusion and stochastic reaction-diffusion modelling. The methods covered include molecular dynamics, Brownian dynamics, velocity jump processes and compartment-based (lattice-based) models.

Author: Frank Schweitzer
Publisher: Springer Science & Business Media
ISBN: 3540738444
Category : Business & Economics
Languages : en
Pages : 427

View

Book Description
This book lays out a vision for a coherent framework for understanding complex systems. By developing the genuine idea of Brownian agents, the author combines concepts from informatics, such as multiagent systems, with approaches of statistical many-particle physics. It demonstrates that Brownian agent models can be successfully applied in many different contexts, ranging from physicochemical pattern formation to swarming in biological systems.

Author: Radek Erban
Publisher: Cambridge University Press
ISBN: 1108498124
Category : Mathematics
Languages : en
Pages : 321

View

Book Description
Practical introduction for advanced undergraduate or beginning graduate students of applied mathematics, developed at the University of Oxford.

Author: Marian Gheorghe
Publisher: Springer Science & Business Media
ISBN: 3642181228
Category : Computers
Languages : en
Pages : 401

View

Book Description
This book constitutes the thoroughly refereed post-conference proceedings of the 11th International Conference on Membrane Computing, CMC11, held in Jena, Germany, in August 2010 - continuing the fruitful tradition of 10 previous editions of the International Workshop on Membrane Computing (WMC). The 23 revised full papers presented together with 4 invited papers and the abstracts of 2 keynote lectures were carefully reviewed and selected from numerous submissions. The papers address in this volume cover all the main directions of research in membrane computing, ranging from theoretical topics in the mathematics and computer science to application issues. A special attention was paid to the interaction of membrane computing with biology and computer science, focusing both on the biological roots of membrane computing, on applications of membrane computing in biology and medicine, and on possible electronically based and bioinspired implementations.

Author: David Holcman
Publisher: Springer
ISBN: 3319626272
Category : Mathematics
Languages : en
Pages : 377

View

Book Description
This book focuses on the modeling and mathematical analysis of stochastic dynamical systems along with their simulations. The collected chapters will review fundamental and current topics and approaches to dynamical systems in cellular biology. This text aims to develop improved mathematical and computational methods with which to study biological processes. At the scale of a single cell, stochasticity becomes important due to low copy numbers of biological molecules, such as mRNA and proteins that take part in biochemical reactions driving cellular processes. When trying to describe such biological processes, the traditional deterministic models are often inadequate, precisely because of these low copy numbers. This book presents stochastic models, which are necessary to account for small particle numbers and extrinsic noise sources. The complexity of these models depend upon whether the biochemical reactions are diffusion-limited or reaction-limited. In the former case, one needs to adopt the framework of stochastic reaction-diffusion models, while in the latter, one can describe the processes by adopting the framework of Markov jump processes and stochastic differential equations. Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology will appeal to graduate students and researchers in the fields of applied mathematics, biophysics, and cellular biology.